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KRAShing pancreatic cancer before takeoff
Science, Volume 391, Issue 6790, Page 1104-1105, March 2026.
In Other Journals
Science, Volume 391, Issue 6790, Page 1116-1117, March 2026.
My new apprentice
Science, Volume 391, Issue 6790, Page 1178-1178, March 2026.
Rapid evolution predicts demographic recovery after extreme drought
Science, Volume 391, Issue 6790, Page 1172-1176, March 2026.
Evolutionary adaptation to global change reduces sustainable fisheries yields
Science, Volume 391, Issue 6790, Page 1167-1171, March 2026.
Cancer interception with KRAS inhibitors in preclinical models of pancreatic ductal adenocarcinoma
Science, Volume 391, Issue 6790, Page 1161-1166, March 2026.
Ravens anticipate wolf kill sites across broad scales
Science, Volume 391, Issue 6790, Page 1151-1154, March 2026.
Seal and sea lion brains have evolved to support volitional control of vocal behavior and learning
Science, Volume 391, Issue 6790, Page 1146-1150, March 2026.
Strong and brittle lithium dendrites
Science, Volume 391, Issue 6790, Page 1125-1129, March 2026.
Antimicrobial resistance in India
Science, Volume 391, Issue 6790, Page 1107-1107, March 2026.
The imminent collapse of the Great Salt Lake
Science, Volume 391, Issue 6790, Page 1106-1106, March 2026.
A deep-time landscape of plant cis-regulatory sequence evolution
Science, Ahead of Print.
Relic of long-vanished ice sheet holds clues to ancient climate
Glacial ice melting out of Alaska’s eroding coastline offers a glimpse into a lost climate history
Universe’s brightest stellar explosions may be powered by highly magnetic neutron stars
Peculiar bumps in light from supercharged supernovae point to a stellar remnant surrounded by a wobbling disk of matter
A genetic trick helps this all-female fish species escape evolutionary doom
The Amazon molly, which reproduces asexually, has survived—and thrived—at least 10 times longer than predicted by evolutionary theory
‘Tour de force’ mouse study shows a gut microbe can promote memory loss
Research suggests the microbiome may contribute to cognitive decline—but its relevance in humans is unclear
Why the Energy Department’s science labs will spearhead the federal push into AI
DOE’s national labs’ huge facilities, data flows, and computing resources are a natural fit for the Genesis Mission
Viagra compound may hold promise for treating fatal genetic disease
Animal studies and preliminary human data support the safety of sildenafil in Leigh syndrome, but the jury’s out on whether it’s effective
The emergence of neuropsychiatric symptoms in preclinical Alzheimer's disease: An emotion regulation perspective
Preclinical Alzheimer's disease (AD) is associated with distressing neuropsychiatric symptoms (NPSs) that may accelerate progression toward dementia. Existing approaches probe the symptom-level domain-general or domain-specific neural correlates of NPSs. However, the field lacks process-oriented models of symptom emergence for targeted treatment. We propose one pathway for symptom emergence involving the disruption of emotion regulation (ER) systems by early AD pathology. AD pathology in the...
Harmine and its derivatives: A promising multi-target therapeutic avenue for Alzheimer's disease
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by β-amyloid (Aβ) deposition, tau hyperphosphorylation, neuroinflammation, and cholinergic dysfunction. Currently, no disease-modifying drugs are available, and existing symptomatic treatments offer limited efficacy while posing safety concerns, highlighting the urgent need for multi‑target therapeutic strategies. The natural β‑carboline alkaloid harmine has attracted considerable attention due to its favorable...