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In Other Journals

2 months 2 weeks ago
Science, Volume 390, Issue 6776, Page 896-897, November 2025.
Corinne Simonti, and Jesse Smith, L. Bryan Ray, Yevgeniya Nusinovich, Peter Stern, Jake S. Yeston, Angela Hessler, Marc S. Lavine, and Corinne Simonti

A fish story

2 months 2 weeks ago
Science, Volume 390, Issue 6776, Page 954-954, November 2025.
Hervé Rogissart

Monkeys have rhythm

2 months 2 weeks ago
Science, Volume 390, Issue 6776, Page 940-944, November 2025.
Vani G. Rajendran, Luis Prado, Juan Pablo Marquez, Hugo Merchant

Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review

2 months 2 weeks ago
CONCLUSION: Exercise can simultaneously impact insulin resistance and Alzheimer's disease pathology in animal models. Results from human research are limited, and no robust evaluation of the potential mediating role of insulin resistance in the physical activity - Aβ or tau relationship exists. Future research should focus on identifying the mediating pathways that may link physical activity to biomarkers of Alzheimer's disease.
Michael G Slee

Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer's disease

2 months 2 weeks ago
Biomolecular condensates, membrane-less assemblies formed by phase separation, are implicated in neurodegenerative disease, but their role in Alzheimer's disease (AD) remains unclear. Here, we report that in the brain of AD patients and animal models, an elevation of poly(C)-binding protein 2 (PCBP2) correlates with biomolecular condensation that involves phase separation. These condensates sequester large numbers of mitochondrial and mRNA-binding proteins, leading to the outside impairment of...
Lu Wang

Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits

2 months 2 weeks ago
Genome-wide association studies have identified many loci for brain disorders, but most non-coding variants fail to colocalize with bulk expression quantitative trait loci. Single-cell expression quantitative trait loci studies capture cell-type-specific regulation but are often underpowered. We developed Bulk And Single cell expression quantitative trait loci Integration across Cell states (BASIC) to combine bulk and single-cell expression quantitative trait loci through "axis-quantitative...
Lida Wang

Organ-specific proteomic aging clocks predict disease and longevity across diverse populations

2 months 2 weeks ago
Aging and age-related diseases share convergent pathways at the proteome level. Here, using plasma proteomics and machine learning, we developed organismal and ten organ-specific aging clocks in the UK Biobank (n = 43,616) and validated their high accuracy in cohorts from China (n = 3,977) and the USA (n = 800; cross-cohort r = 0.98 and 0.93). Accelerated organ aging predicted disease onset, progression and mortality beyond clinical and genetic risk factors, with brain aging being most strongly...
Yunhe Wang