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Daily briefing: New AI drug-discovery engine is ‘on the scale of an AlphaFold4’
Whistle while you whinny: researchers identify two sounds straight from the horse’s mouth
First-of-a-kind stem-cell therapies set for approval in Japan
Iron Age mass grave reveals unprecedented violence against women and children
Markovnikov hydroamination of terminal alkenes via phosphine redox catalysis
Attenuating age-related decline in dendritic cell migration improves vaccine efficacy via gut-immune crosstalk
Music is not a universal language — but it can bring us together when words fail
How big is the ‘motherhood penalty’? In Denmark, it adds up to $120,000
This AI can improve your peer review — and make it more polite
Historically Black US universities chase top research ranking
AI tools can design genomes. Will they upend how life evolves?
Why every scientist needs a librarian
From Victorian voyages to vanishing maps: Books in brief
Ancient artifacts hint at earliest protowriting
Geometric shapes on 40,000-year-old bone and ivory suggest early European Homo sapiens long possessed cognitive tools for language
Hubble spotted a ‘dark galaxy’ that’s at least 99.9% dark matter
Search through space telescope’s archival images reveals unusually dim galaxy
Ancient rocks point to an early start for the Great Unconformity—the biggest gap in Earth’s rock record
Two-billion-year-old rocks in China suggest mountain building from Earth’s first supercontinent led to a planetwide burst of erosion
Multimorbidity Among Adults Aged 50 and Over in Europe and Israel: Prevalence and Associated Factors From SHARE Wave 9
CONCLUSIONS AND IMPLICATIONS: The high prevalence and cross-country differences highlight the complexity of multimorbidity among adults aged 50 years and older in Europe and Israel. The findings reinforce the influence of demographic, clinical, and lifestyle factors and emphasize the need for public policies promoting healthy aging and integrated health care.
Entropy of Muscle Fiber Histology Predicts Mobility in Older Adults: The Study of Muscle, Mobility, and Aging
Entropy may play an underappreciated role in human aging, such as in skeletal muscle functional declines. Histologically, muscle appears increasingly disorganized with aging, with greater fiber size variability and fiber-type grouping. We tested the hypothesis that entropy is associated with reduced physical performance and muscle function, independent of muscle mass. We quantified a homeostatic dysregulation index of muscle (HDI(M)) as a proxy for entropy of muscle fiber disorganization based...
Ageing Through the Looking-Glass: The Different Flavours of Clonal Haematopoiesis
Clonal haematopoiesis (CH) is the presence of acquired mutations in blood cells and is a consequence of ageing that is linked to malignancy, cardiovascular disease and other diseases of ageing. CH is a reflection of genomic instability with ageing; however, there is evidence that CH may exacerbate features of normal ageing, including inflammageing and immunosenescence, and more directly contribute to disease causation. CH can manifest as mosaic loss of X or Y, autosomal mosaic chromosomal...
Adaptive deep brain stimulation in Parkinson's disease
With the introduction of adaptive deep brain stimulation (aDBS) for Parkinson's disease, new questions emerge regarding who, why, and how to treat. This paper outlines the pathophysiological rationale for aDBS, which provides real-time modulation of the stimulation amplitude based on subthalamic beta (range 13-30 Hz) activity and related physiomarkers. We review clinical evidence comparing aDBS with conventional DBS in terms of motor improvement, side-effect reduction, energy efficiency, and...