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Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle-Age and Older Men With Low Testosterone

2 months 1 week ago
Middle-aged/older (MA/O) men with low testosterone have greater oxidative stress-mediated vascular endothelial dysfunction, a major risk factor for cardiovascular disease (CVD). Testosterone deficiency impairs mitochondria, a source and target of oxidative stress. Whether the greater vascular endothelial dysfunction in MA/O men with low testosterone is related to mitochondrial dysfunction is unknown. This cross-sectional study measured mitochondrial respiration in peripheral blood mononuclear...
Branden L Nguyen

Ghrelin Receptor Deletion or Pharmacological Inhibition Improves Muscle Function in Aging Male Mice

2 months 1 week ago
Sarcopenia is characterized by age-related declines in muscle strength and mass, along with impaired physical function. It remains an unmet medical need, and there are no pharmacological interventions approved for this indication. The activation of growth hormone secretagogue receptor (GHSR)-1a, also known as ghrelin receptor, stimulates food intake and has acute anabolic effects. However, its impact on aging muscles remains uncertain. We examined the effects of GHSR-1a deletion on sarcopenia...
Haiming L Kerr

In Science Journals

2 months 1 week ago
Science, Volume 392, Issue 6795, Page 265-267, April 2026.
Michael Funk, and Madeleine Seale, Phil Szuromi, Keith T. Smith, Angela Hessler, Mattia Maroso, Stella M. Hurtley, Molly Ogle, Wei Wong, Marc S. Lavine, Yevgeniya Nusinovich, Sacha Vignieri, Sarah H. Ross, Di Jiang, and Claire Olingy