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Science, Volume 390, Issue 6770, Page 304-307, October 2025.

Science, Volume 390, Issue 6770, Page 299-303, October 2025.

Science, Volume 390, Issue 6770, Page 246-246, October 2025.

Science, Volume 390, Issue 6770, Page 247-247, October 2025.

Science, Volume 390, Issue 6777, Page 1029-1032, December 2025.

Science, Volume 390, Issue 6777, Page 1050-1056, December 2025.

Science, Volume 390, Issue 6776, Page 911-917, November 2025.

Science, Volume 390, Issue 6771, Page 317-317, October 2025.

Scientists are hunting for ancient RNA in Svalbard’s permafrost, hoping to shed light on the evolution of viral diseases

An unusual relationship could shed light on how insects choose their partners

Excusing record-keeping “misconduct” flagged in earlier investigative report, City University of New York concluded in letter that image doctoring by Hoau-Yan Wang was not proved

New fossils reveal Paranthropus had massive yet dexterous hands

Ovarian aging plays a pivotal role in female reproductive health, with implications for treatment strategies and quality of life. However, the potential of a single pharmaceutical agent to mitigate primate ovarian aging remains largely unexplored. Our 3.3-year study in monkeys demonstrates that oral vitamin C has geroprotective effects against ovarian aging. Vitamin C diminishes key aging biomarkers, including oxidative stress and follicular depletion. Using a single-cell transcriptomic clock,...

BACKGROUND: For more than three decades, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) has provided a framework to quantify health loss due to diseases, injuries, and associated risk factors. This paper presents GBD 2023 findings on disease and injury burden and risk-attributable health loss, offering a global audit of the state of world health to inform public health priorities. This work captures the evolving landscape of health metrics across age groups, sexes, and...

BACKGROUND: Comprehensive, comparable, and timely estimates of demographic metrics-including life expectancy and age-specific mortality-are essential for evaluating, understanding, and addressing trends in population health. The COVID-19 pandemic highlighted the importance of timely and all-cause mortality estimates for being able to respond to changing trends in health outcomes, showing a strong need for demographic analysis tools that can produce all-cause mortality estimates more rapidly with...

BACKGROUND: Timely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 provides cause-specific mortality estimates measured in counts, rates, and years of life lost (YLLs). GBD 2023 aimed to enhance our understanding of the relationship between age and cause of death by quantifying the probability of...

The discovery of non-toxic, bioresorbable silicon electronics is a major breakthrough in the fields of transient, dissolvable biomedical implants and environmental monitors, as it opens up the possibility of producing versatile components based on established semiconductor processes. However, given the limited lifespan of such electronics, it is essential to consider economical manufacturing and production strategies that reduce the unit price for commercialization. Here, we introduce a...

Aging is the most important risk factor for multiple pathologies including cardiovascular, neoplastic, metabolic and neurodegenerative diseases. Potential geroprotective strategies involve lifestyle-related, nutritional and pharmacological interventions. Recently, chalcones, a subgroup of secondary plant metabolites, have gained attention. 4,4'-dimethoxychalcone was the first chalcone to be shown to mediate geroprotection and lifespan extension across different species. Several other chalcones...

The insulin receptor entrains tissue growth and metabolism to nutritional conditions. Complete loss of function in humans leads to extreme insulin resistance and infantile mortality, while loss of 80-90% function permits longevity of decades. Even low-level activation of severely compromised receptors, for example by anti-receptor monoclonal antibodies, thus offers the potential for decisive clinical benefit. A barrier to genetic diagnosis and translational research is the increasing...

All mammalian organs depend on resident macrophage populations to coordinate repair and facilitate tissue-specific functions^(1-3). Functionally distinct macrophage populations reside in discrete tissue niches and are replenished through a combination of local proliferation and monocyte recruitment^(4,5). Declines in macrophage abundance and function have been linked to age-associated pathologies, including atherosclerosis, cancer and neurodegeneration^(6-8). However, the mechanisms that...