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Mapping and engineering RNA-driven architecture of the multiphase nucleolus
The Somatic Mosaicism across Human Tissues Network
The mutagenic forces shaping the genomes of lung cancer in never smokers
Whole-genome ancestry of an Old Kingdom Egyptian
A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
Plants monitor the integrity of their barrier by sensing gas diffusion
Functional amyloid proteins confer defence against predatory bacteria
Mapping the adaptive landscape of Batesian mimicry using 3D-printed stimuli
Stereodivergent transformation of a natural polyester to enantiopure PHAs
Boron-mediated modular assembly of tetrasubstituted alkenes
Massive submarine eruption darkened clouds half a world away
3D-printed fake wasps help explain bad animal mimicry
Three tips for talking to a vaccine sceptic
Ancient DNA helps trace stinky Roman fish sauce to its source
AI ‘scientists’ joined these research teams: here’s what happened
Exclusive: Famed protein structure competition nears end as NIH grant money runs out
Agency silent on funding renewal for contest that inspired creation of AIs that predicted how proteins would fold
A PKCeta missense mutation enhances Golgi-localized signaling and is associated with recessively inherited familial Alzheimer's disease
The identification of Alzheimer's disease (AD)-associated genomic variants has provided powerful insight into disease etiology. Genome-wide association studies (GWASs) of AD have successfully identified previously unidentified targets but have almost exclusively used additive genetic models. Here, we performed a family-based GWAS of a recessive inheritance model using whole-genome sequencing from families affected by AD. We found an association between AD risk and the variant rs7161410, which is...
Restoration of striatal neuroprotective pathways by kinase inhibitor treatment of Parkinson's disease-linked LRRK2-mutant mice
Parkinson's disease is associated with activating mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2), which suppresses primary cilia formation in cholinergic and parvalbumin interneurons and astrocytes in the striatum. As a result, there is a decrease in the production of neuroprotective glial cell line-derived neurotrophic factor (GDNF) and neurturin (NRTN), which normally support the viability of dopaminergic neurons. MLi-2 is a brain-penetrant, selective, and now experimental...
Association between self-reported multimorbidity and longitudinal brain Abeta deposition in Alzheimer's disease
Multimorbidity is common in older adults. However, whether multimorbidity accelerates brain beta-amyloid (Aβ) deposition, the molecular driver of Alzheimer's disease (AD), in humans remains largely unknown. In this study, we selected 435 brain Aβ-positive participants with available longitudinal Aβ-PET data (mean duration 3.9 years) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. Twenty-two self-reported chronic disorders were considered as a measure of the severity of...
Integrated dopamine sensing and 40 Hz hippocampal stimulation improves cognitive performance in Alzheimer's mouse models
Hippocampal degeneration and reduced dopamine levels in Alzheimer's disease are associated with severe memory and cognitive impairments. However, the lack of multifunctional in situ neural chips has posed challenges for integrated investigations of Alzheimer's disease pathophysiology, dopamine dynamics, and neural activity. Therefore, we developed NeuroRevive-FlexChip, a flexible neural interface capable of precise electrical modulation and simultaneous in situ monitoring of dopamine levels and...