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River oxygen levels are dropping around the world as Earth warms
Accelerating scientific discovery with Co-Scientist
An AI system to help scientists write expert-level empirical software
A multi-agent system for automating scientific discovery
A unifying model of stem cell dynamics explains age-related methylation patterns across mammals
‘It is incredible’: How AI is transforming mathematics
DNA-folding changes block production of self-directed antibodies
The uncritical adoption of AI in science is alarming — we urgently need guard rails
Airborne DNA can yield insights with the right techniques
France’s research-primate project goes against its own ethics panel
Support academic institutions under attack
AI might jeopardize the uncertainty required in science
China moves AI brain implants from trials towards real-world use
Vaccine experts debate options to combat outbreak of unusual Ebola strain
Small monkey experiments raise some hopes—and many questions
Can extra snoozing reverse the health hazards of a bad night’s sleep?
Catching more z’s the day after a shortened slumber appears to reduce risk of early death
A new genetically modified rice could improve children’s health. But will it be grown?
Philippines takes first step toward approving rice with increased iron and zinc
Hidden sugar patterns on human cells could reveal cancer early
Scientists have uncovered a hidden “sugar code” on the surface of human cells that could transform how diseases are detected. Using an advanced imaging technique called Glycan Atlasing, researchers at the Max Planck Institute mapped the tiny sugar structures coating cells and discovered that these patterns shift depending on what the cell is doing. Immune cells changed their sugar layouts when activated, and cancerous tissues displayed distinct surface signatures compared to healthy tissue.
Eating grapes daily could unlock powerful skin protection
Scientists discovered that eating grapes can actually change how your skin behaves at the genetic level. After just two weeks of daily grape consumption, volunteers showed signs of improved skin protection and reduced oxidative stress from UV exposure. Researchers say the effects appear widespread, even though every person’s genes responded a little differently.
Predicting categorical and continuous Alzheimer's disease outcomes from a single MRI scan
Deep learning (DL) has shown success in predicting Alzheimer's disease (AD) diagnosis, yet continuous measures such as cognitive assessment remain critical for richer prognosis, trajectory tracking and clinical trial enrichment. Current neurocognitive batteries are time-consuming, and the few DL models predicting cognition require expensive multimodal neuroimaging and longitudinal data. Although magnetic resonance imaging (MRI) is the most clinically accessible modality, on its own it struggles...
Spatial proteomic analysis in human Alzheimer's disease brains enables identification of microenvironment-dependent microglial cell states
Disease-associated microglial states are thought to contribute to Alzheimer's disease (AD) progression, but characterizing them and their relationships to pathology remains challenging. Here we introduce CODEX-CNS-a multiplexed protein imaging technology with a custom data analysis pipeline for use in human brain samples. We profiled 704,706 cells in samples from the frontal cortex of 8 people with AD and 8 healthy controls and mapped features including blood-brain barrier, meningeal components...