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In the absence of telomerase, telomere shortening triggers replicative senescence, a tumor suppressor mechanism that is also associated with oncogenic genomic instability. Yet, the precise mechanism that connects these seemingly opposing forces remains poorly understood. To directly study the complex interplay between senescence, telomere dynamics, and genomic instability, we develop a system in Saccharomyces cerevisiae to generate and track telomeres of precise length in the absence of...

Analysis of Wuhan market map suggests China has not disclosed some of the earliest infections in animals and people

Neolithic seafarers who settled Palau were already a blend of Asian and Papuan peoples

Experiments show the crop can survive in lunar soil—with a lot of help

White House review of agency spending plans for this year is causing delays

Bhashini aims to put the power of AI in the hands of all Indians

Alzheimer's disease (AD), an age-associated neurodegenerative disorder, is characterized by progressive cognitive decline, amyloid-β (Aβ) accumulation (including soluble oligomers and deposited aggregates), lipid dysregulation, and neuroinflammation. Although mutations in the amyloid precursor protein (APP) and accumulation of Aβ42 are established drivers of pathology, the mechanisms connecting oligomeric amyloid toxicity with lipid metabolism and inflammatory responses remain poorly understood....

The brain age gap (BAG) is defined as the difference between brain age estimated from MRI using artificial intelligence and chronological age, and has been proposed as a biomarker reflecting aging and neurodegeneration. However, the association between BAG and dementia-related biomarkers has yielded inconsistent findings in previous studies. Conventional training datasets have primarily been defined based on medical history and MRI findings, which may have included participants with underlying...

CONCLUSIONS: Dance serves as an effective nonpharmacological strategy for promoting healthy aging. Based on current evidence, public health policymakers should prioritize resource allocation toward the 70- to 75-year-old community-dwelling population. Regarding dance prescription design, we advocate for an 8-week baseline cycle to generate significant benefits and highlight the potential value of short-duration models (∼20 minutes) in enhancing adherence and improving function. However, given...

Alzheimer's disease (AD), an age-associated neurodegenerative disorder, is characterized by progressive cognitive decline, amyloid-β (Aβ) accumulation (including soluble oligomers and deposited aggregates), lipid dysregulation, and neuroinflammation. Although mutations in the amyloid precursor protein (APP) and accumulation of Aβ42 are established drivers of pathology, the mechanisms connecting oligomeric amyloid toxicity with lipid metabolism and inflammatory responses remain poorly understood....