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CONCLUSIONS AND IMPLICATIONS: Despite methodological variation, community-based programs that reduce loneliness, social isolation, and support aging in place consistently generate positive SROI ratios, benefiting participants, families, and volunteers while reducing health care use. Collaboration among researchers, communities, and policymakers is essential to translate findings into community actions that enable older adults to age in place.

CONCLUSIONS AND IMPLICATIONS: Stable health trajectories are strongly linked to better cognitive outcomes, whereas sharp health declines predict poorer cognition. Our findings highlight the interconnected biological and behavioral pathways through which health changes may accelerate or mitigate cognitive deterioration, offering insights for targeted interventions and holistic care for persons with cognitive impairment.

Mutations in PINK1 and PRKN/parkin are the leading recessive causes of Parkinson disease (PD). Together PINK1 and PRKN form a mitophagy pathway for clearing damaged mitochondria from the cell. It was unclear, however, whether diverse forms of mitochondrial damage activate the PINK1-PRKN pathway through a unified mechanism. Recently, we demonstrated that loss of mitochondrial membrane potential (MMP) leads to the stabilization and activation of PINK1 under a wide range of mitochondrial stressors,...

DNA replication stress responses are guardians of genomic stability critical during development, hematopoiesis, cancer therapy response, aging and disease suppression. Central to these responses are reversed forks (RF), which are distinct four-way DNA structures formed during DNA replication stalling to protect against toxic DNA lesions. Historically, RF detection relies on specialized electron microscopy, precluding studies within their native cellular context. By harnessing intrinsic...

CONCLUSIONS: We propose that aging affects RFT performance through two dissociable mechanisms. A general decline in multisensory integration increases overall errors symmetrically across tilt angles. The clockwise-specific asymmetry, by contrast, may reflect age-related changes in lateralized visuospatial attention-specifically, the well-documented rightward attentional shift that accompanies healthy aging-which differentially affects the weighting of visual cues for clockwise vs....

Cognitive impairment associated with obstructive sleep apnea (OSA) is more prevalent and severe in the elderly, possibly due to age-related increases in neuronal susceptibility to intermittent hypoxia (IH). As telomere dysfunction is a key driver of cellular aging, this study aimed to characterize the interaction between telomere dysfunction and IH, and to explore the associated molecular alterations. Using telomere-damaged PC12 cells and G3 Tert^(-/-) progeria mice exposed to IH, we assessed...

OBJECTIVE: Cerebral microbleeds (CMBs) are small vascular lesions detectable on MRI and are associated with increased stroke risk and cognitive decline. However, imaging-based diagnosis is limited by cost and accessibility. This study aimed to identify serum protein biomarkers for early CMB diagnosis and to elucidate molecular mechanisms underlying CMB subtypes.

A pair of studies illuminates these humans’ long, hardscrabble existence

Given autonomous control of other software, programs shared private medical details and deleted files without permission

At least 56 cultural sites have been damaged since strikes began in February—but internet blackouts and academic isolation are obscuring the true toll

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BACKGROUND: Evidence, including animal, clinical, and real-world studies in individuals with type 2 diabetes and/or obesity, suggests reduced risk of dementia and Alzheimer's disease after GLP-1 receptor agonist exposure. The evoke and evoke+ trials aimed to investigate the efficacy and safety of oral semaglutide in individuals with early Alzheimer's disease.