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The brain–body energy conservation model of aging
Senescent stromal fibroblasts in bladder tumors support cancer progression
What if Marie Curie’s greatest legacy was not her two Nobel prizes?
How to keep research afloat during an administrative stint
Physics Nobel scooped by machine-learning pioneers
Which is the fairest electoral system? Mega-election year sparks debate
Biases in ‘sustainable finance’ metrics could hinder lending to those that need it most
Tips to beat ‘brain drain’: how to foster home expertise from abroad
Unevidenced biodiversity claim should be abandoned — but biodiversity can be counted
Establish global standards to protect childhood cancer genomics data
GPS tracking reveals how hares shape lynx populations
Congress is threatening funding of US firearm-injury prevention research — again
South Korea’s emissions-reduction plan declared unconstitutional in a landmark climate case
In a surprise, AI pioneers win physics Nobel
John Hopfield and Geoffrey Hinton honored for early work on artificial neural networks
This jelly is really two in one
Injured sea walnuts can join bodies and thrive again by merging some of their systems
Decoding paradoxical links of cytokine markers in cognition: Cross talk between physiology, inflammaging, and Alzheimer's disease- related cognitive decline
Recent research has revolutionized our understanding of memory consolidation by emphasizing the critical role of astrocytes, microglia, and immune cells in through cytokine signaling. Cytokines, compact proteins, play pivotal roles in neuronal development, synaptic transmission, and normal aging. This review explores the cellular mechanisms contributing to cognitive decline in inflammaging and Alzheimer's disease, highlighting the paradoxical effects of most studied cytokines (IL-1, IL-6, TNF-α)...
Life expectancy rise in rich countries slows down: why discovery took 30 years to prove
No abstract
Disease-modifying therapies for Parkinson disease: lessons from multiple sclerosis
The development of disease-modifying therapies (DMTs) for neurological disorders is an important goal in modern neurology, and the associated challenges are similar in many chronic neurological conditions. Major advances have been made in the multiple sclerosis (MS) field, with a range of DMTs being approved for relapsing MS and the introduction of the first DMTs for progressive MS. By contrast, people with Parkinson disease (PD) still lack such treatment options, relying instead on decades-old...
Biological constraint, evolutionary spandrels and antagonistic pleiotropy
Maximum lifespan differs greatly between species, indicating that the process of senescence is largely genetically determined. Senescence evolves in part due to antagonistic pleiotropy (AP), where selection favors gene variants that increase fitness earlier in life but promote pathology later. Identifying the biological mechanisms by which AP causes senescence is key to understanding the endogenous causes of aging and its attendant diseases. Here we argue that the frequent occurrence of AP as a...
Decoding Paradoxical Links of Cytokine Markers in Cognition: Cross talk between Physiology, Inflammaging, and Alzheimer's Disease- Related Cognitive Decline
Recent research has revolutionized our understanding of memory consolidation by emphasizing the critical role of astrocytes, microglia, and immune cells in through cytokine signaling. Cytokines, compact proteins, play pivotal roles in neuronal development, synaptic transmission, and normal aging. This review explores the cellular mechanisms contributing to cognitive decline in inflammaging and Alzheimer's disease, highlighting the paradoxical effects of most studied cytokines (IL-1, IL-6, TNF-α)...