Aggregator

Analysis suggests Earth’s mantle is peeling from the crust in the eastern Atlantic, a possible sign of the ocean’s eventual closure

New report recommends improved education and genetic counseling alongside NCAA’s mandated screening

New algorithm could help scientists avoid publishing in shady titles

Beloved physicist sketched out the concept that would lead to one of the biggest discoveries in physics and astronomy

CONCLUSIONS: Tailoring intervention strategies according to specific health statuses of older adults may prevent and delay CF onset and facilitate recovery from MCI and PF.

Microglia-driven dysregulation has emerged as a significant underlying mechanism in many neurodegenerative diseases, such as age-related macular degeneration (AMD) and Alzheimer's disease (AD). Although both brain and retinal microglia originate from the yolk sac, it is uncertain whether they share molecular similarities or genetic and molecular foundations related to neurodegenerative diseases. In this study, we examine the transcriptomic and epigenetic profiles of retina and brain microglia...

A hallmark of Alzheimer's disease (AD) is the accumulation of extracellular amyloid-β plaques in the brain. Amyloid-β is a 40-42 amino acid peptide generated by proteolytic processing of amyloid precursor protein (APP) via membrane-bound proteases. APP is a transmembrane protein, and its trafficking to sites of proteolysis represents a rate-limiting step in AD progression. Although APP processing has been well-studied, its trafficking itinerary and machinery remain incompletely understood. To...

A growing body of evidence shows that epileptic activity is frequently observed in patients with Alzheimer's disease (AD), implicating underlying excitatory-inhibitory imbalance. The distinction of whether the AD-epileptic phenotype represents a subset of patients or an underdiagnosed manifestation holds major therapeutic implications. Here, we quantified the excitatory-inhibitory imbalance in AD patients using magnetoencephalography and examined the relationships to AD...

T cell dysfunction with age underlies an increased incidence of cancer in elderly individuals; however, how T cell aging is triggered in the tumor microenvironment is unclear. Here, we show that an age-associated reduction in adipocyte-derived leptin contributes to the accumulation of tumor-infiltrating senescent CD8^(+) T cells. Single-cell profiling of human and mouse cancer tissues reveals that the frequency of intratumoral senescent CD8^(+) T cells increases with age, leading to a weak...