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How your brain chemistry rewards hard work
Publisher Correction: Shear stress governs hematopoietic stem cell fate to promote inflammation-induced aging
Technologies to give a clearer view of the lungs
How ‘forest bathing’ keeps lungs healthy
The unfortunate embossing of Subsector XZ-74
Could the regenerative power of the lungs help to reverse disease?
The surprisingly big health benefits of just a little exercise
Wikipedia is needed now more than ever, 25 years on
Six highlights from lung-health research
Treatments for idiopathic pulmonary fibrosis are on the horizon
Funding cuts could put research into emerging threats to lung health at risk
Exposome studies can improve lung health
Deep-sea robots will search for source of mysterious ‘dark oxygen’
Act now to clean up air
How much exercise do you really need?
Preserving the respiratory system
The glymphatic system clears amyloid beta and tau from brain to plasma in humans
Dysfunction of the glymphatic system has been proposed as a mechanistic link between sleep disruption and Alzheimer's disease (AD). In animal models, glymphatic impairment alone can drive AD pathology. Whether this system clears amyloid beta (Aβ) and tau in humans remains unknown. In a randomized crossover trial with 39 participants, we found that glymphatic clearance during normal sleep increased morning plasma levels of AD biomarkers compared to sleep deprivation. Participants underwent...
Clonal CD8<sup>+</sup> T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases
Meningeal immune cells monitor the central nervous system (CNS) and influence neuroinflammation in mice, but the human leptomeningeal immune landscape and the changes that occur in this immunological niche in neurodegeneration remain underexplored. Here we performed single-cell RNA and T cell receptor (TCR) sequencing of 99,625 high-quality immune cells from 57 leptomeninges and brain samples from donors with Alzheimer's disease (AD), amyotrophic lateral sclerosis and Parkinson's disease and...
Still working at 107: supercentenarian study probes genetics of extreme longevity
No abstract
Age-related diversity of the oral and gut microbiome and its correlation with systemic fatty acids and cytokine profiles in healthy subjects
CONCLUSION: To our knowledge, this study is the first to characterize and correlate the diversity of both the OM and GM with systemic FFA and cytokine profiles in a cohort of healthy adults, highlighting the critical role of age in shaping microbiome composition and associated metabolites. Integrating microbiota profiling with serum FFA and cytokine measurements enhances our understanding of how the microbiome may influence health and disease risk across the adult lifespan.