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CONCLUSIONS AND IMPLICATIONS: Lower predictive performance for rectal fever prediction in older adults supports using an oral threshold of 37.2 °C in high-risk hospitalized adults aged ≥75 years. Adjusting oral thresholds in older adults may improve infection detection and management.

Age-related hearing loss (ARHL) is a progressive, bilateral sensorineural impairment with significant socio-psychological consequences. Current ARHL models (natural aging or systemic D-galactose (D-gal) injection) face limitations: prolonged timelines, high variability, and inconsistent D-gal protocols. To concentrate aging pathology within the peripheral auditory system, we developed a novel accelerated cochlear aging model by targeted delivery of D-gal via the posterior semicircular canal....

CONCLUSIONS: Monitoring intrinsic capacity changes, especially locomotion decline, enables early identification of vulnerable older adults and supports timely, targeted interventions to reduce adverse outcomes.

The accelerating ageing of populations worldwide presents profound challenges for public health, particularly within long-term care facilities (LTCFs). Older adults, often burdened by multimorbidity, frailty, and immunosenescence, are highly vulnerable to vaccine-preventable diseases such as influenza, pneumococcal pneumonia, COVID-19, respiratory syncytial virus (RSV), pertussis, and herpes zoster (HZ). Despite the availability of effective vaccines, immunization coverage in LTCFs remains...

Iron homeostasis which is primarily regulated through intestinal iron absorption, is usually disrupted in the elderly. But changes of intestinal iron absorption with aging have not been elucidated. This study aims to investigate the role of intestinal iron absorption in driving age-related disruption of iron homeostasis. Male C57BL/6 J mice aged 2, 12, 18, and 24 months were utilized in this study to analyze age-related changes in systemic iron status, detect the alterations in intestinal iron...

Aging increases the risk of neurodegeneration, cognitive decline, and Alzheimer's disease (AD). We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan. UCH-L1 concentrations rise faster in females, who exhibit increased AD risk. Glial fibrillary acidic protein (GFAP) concentrations increase...

Neuroimaging studies have highlighted both hyperconnectivity and hypoconnectivity across the Alzheimer's disease (AD) continuum, alongside task-induced activity changes. These alterations may reflect compensatory mechanisms or network breakdowns. While connectivity-based measures are not yet established as clinical biomarkers, they hold promises for evaluating therapeutic efficacy and informing the design of targeted interventions. Based on these insights, this review explores the potential of...

Alzheimer's disease (AD) is the most chronic neurodegenerative disease. The pathological hallmark of AD includes the accumulation of amyloid-beta plaques (Aβ), oxidative stress as well as chronic inflammatory reactions. Current treatments, such as acetylcholinesterase inhibitors, N-methyl-D-aspartate (NMDA) receptor antagonists, and recently approved monoclonal antibodies, offer symptomatic relief or slightly slow down progression. However, they too are constrained by high cost, side effects and...

Hydrogen sulfide is a gasotransmitter with biological functions, including roles in antioxidant defenses, mitochondrial bioenergetics, and cellular signaling via cysteine persulfidation. Several longevity-promoting interventions enhance endogenous hydrogen sulfide generation. However, whether enhanced hydrogen sulfide generation extends healthspan and lifespan in mammals remains unknown. Here, we investigated the in vivo effects of the non-enzymatic hydrogen sulfide generation promoted by...

Aging increases the risk of neurodegeneration, cognitive decline, and Alzheimer's disease (AD). We report that plasma concentrations of ubiquitin C-terminal hydrolase-L1 (UCH-L1) and neurofilament light (NfL) become exponentially higher from ages 2 to 85 in cross-sectional samples, serving as neuronal death/damage biomarkers across the lifespan. UCH-L1 concentrations rise faster in females, who exhibit increased AD risk. Glial fibrillary acidic protein (GFAP) concentrations increase...

CONCLUSIONS AND IMPLICATIONS: A long sleep duration (≥9 hours) is a risk factor for a decline in walking speed among men aged 60 years and older. Routine assessment of sleep duration in primary care provides a low-cost, scalable strategy to identify older adults at risk and guide early interventions aimed at maintaining mobility and independence, especially among older men.

CONCLUSIONS: In later life, being frail does not necessarily imply low IC, and vice versa. Frailty and low IC identify different groups in early older age, but the overlap between them becomes more pronounced with increasing age. Comprehensive assessment of ageing therefore requires measures that capture both vulnerability to decline and capacity.

Lithium-ion battery (LIB) recycling is crucial for energy security, environmental sustainability, and economic viability, as the finite lifespan of LIBs results in a significant annual accumulation of spent units. However, effectively and precisely recovering valuable metal ions such as Li^(+), Mn^(2+), Ni^(2+) and Co^(2+) from complex LIB leaching solutions remains a major challenge. Here, we present a scalable electro-membrane crystallization-assisted general recycling (e-MCGR) technology for...

White adipose tissue (WAT) is the primary energy storage organ and can be categorized mainly into subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). Although all WAT accumulates triglycerides to store excess energy, VAT is associated with pathological conditions, whereas SAT is considered beneficial for metabolic health. In fact, SAT and VAT are from distinct developmental origins. Moreover, within these depots, there is heterogeneity in developmental origin and in adipose...

CONCLUSION: These results demonstrated that plasma metabolomics, particularly amino acid and lipid metabolism, were associated with EAA and aging. The "cysteine and methionine metabolism" pathway emerged as a potential mechanism of aging, and may underpin metabolic alterations during the aging process, and its metabolites, such as methionine, 5-methylthioadenosine, and α-ketobutyrate, may serve as intervention targets.

This study examines the relationship between depression and clinical functioning among cognitively normal (CN) and mildly cognitively impaired (MCI) older adults, with a specific focus on cross-ethnic comparisons between Hispanic and White non-Hispanic (WNH) populations. Despite a significant body of research linking depression to cognitive decline, limited studies have explored how this relationship differs across ethnic groups. Using data from the 1Florida Alzheimer's Disease Research Center...

CONCLUSIONS: Among older adults in China, lifestyles only mediate a small proportion of frailty disparities in overall survival; consequently, without direct interventions for frailty or additional favorable measures, promoting healthy lifestyles alone is insufficient to significantly reduce frailty disparities in survival. Furthermore, individuals of frailty and unhealthy lifestyles experience significantly shorter survival, highlighting the urgent need for targeted interventions for this...

CONCLUSION: This study offers a culturally nuanced understanding of AIP, challenging the notion that 'place' is solely a physical or geographical location. It highlights the significance of social connectedness, emotional security, digital participation, and the desire to avoid institutional care. These findings provide valuable insights for policymakers and practitioners, underscoring the need to design ageing policies and care practices that address not only physical housing but also social...

Sophisticated bots risk contaminating surveys, games, and other approaches designed to shed light on human behavior

During deep co-evolution of viruses and host cells, viruses have selected specific host cellular proteins redirected from physiological functions to viral needs, thereby disturbing cellular proteostasis and increasing the risk of triggering protein misfolding diseases (PMDs). Identifying virus-specific, repurposed host proteins also allows the study of fundamental cellular events in "sporadic" PMDs, independent of the virus. Here, we identify a small molecule with very strong activity against...