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Cycloneolitsol prolongs the lifespan of Caenorhabditis elegans by SEK-1/PMK-1/SKN-1 pathway and exerts anti-inflammatory effects by NF-kappaB pathway
Aging is a major risk factor for the onset and progression of many neurodegenerative diseases. Inflammation is the body's natural defense mechanism against harmful stimuli. A growing body of research has highlighted the intricate relationship between aging and inflammation, with chronic low-grade inflammation, often referred to as "inflammaging," being a hallmark of the aging process. Cycloneolitsol (CL) is a C-32 cycloartane-type triterpene from Taxodium ascendens which has been reported to...
Effect of Obstructive Sleep Apnea and CPAP on Telomere Length and Its Associated Mechanisms: A Pilot Study
The present study aimed to investigate the effect of obstructive sleep apnea (OSA) and its treatment with continuous positive airway pressure (CPAP), the gold standard treatment for OSA on changes of telomere length and its associated mechanisms. In this mechanistic pilot study of a selective patient population (middle-aged men, BMI < 35 kg/m², moderate-severe OSA), a 6-month randomized, double-blind, and sham-controlled clinical trial was conducted (Clinical Trials: NCT04872816, April 29, 2021...
Severity of dual sensory loss and cognitive impairment in institutionalized older adults: a cross-sectional study in Galicia
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Scientific conferences can be a bore. Can jokes liven them up?
Science speaks with ecologist Stefano Mammola about the power of humor to enhance science communication