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Age-Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy

2 months 1 week ago
Biological sex is a crucial, but poorly understood variable in age-related susceptibility to infection. Monocytes are important immune cells responsible for initiating and resolving inflammatory responses to infection. While changes in monocyte populations result in increased susceptibility to infection, there is limited research on the impact of age and sex on human monocyte phenotype and function. The aim of this work was to dissect the impact of increasing age and biological sex on human...
R P H De Maeyer

mRNA initiation and termination are spatially coordinated

2 months 1 week ago
Science, Volume 390, Issue 6769, October 2025.
Ezequiel Calvo-Roitberg, Christine L. Carroll, GyeungYun Kim, Valeria Sanabria, Sergey V. Venev, Steven T. Mick, Joseph D. Paquette, Maritere Uriostegui-Arcos, Job Dekker, Ana Fiszbein, Athma A. Pai