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Antibodies unleashed against pancreatic cancer
Daily briefing: Custom-made gene-editing therapy for children to enter clinical trial
My funding applications are taking up too much time. How can I stay focused on my research?
‘Memory foam’ skeleton in cells helps them to navigate
Alzheimer’s decline slows with just a few thousand steps a day
How to fight climate change without the US: a guide to global action
From pangolins to primates: how I use zoo facilities to treat wild animals
Accelerating the discovery of multicatalytic cooperativity
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy
‘Biotech Barbie’ says the time has come to consider CRISPR babies. Do scientists agree?
Insiders warn how dismantling federal agencies could put science at risk
PhD training needs a reboot in an AI world
Sex, drugs and the conscious brain: Francis Crick beyond the double helix
Letters to scientific journals surge as ‘prolific debutante’ authors likely use AI
New study reinforces worries about “mass production of junk” by unscrupulous scholars aiming to pad their CVs
Oligo fucoidan alleviates sarcopenia via attenuating muscle mass loss and function decline in senescence-accelerated mouse prone 8 mice
CONCLUSION: Our findings show that OliFuco is a promising nutritional intervention for mitigating sarcopenia by preserving muscle mass and function in aging populations, offering a novel strategy to address age-related muscle decline.
Contradictory dual role of antinutrients in nutrient inhibition and anti-aging: A comprehensive review on health benefits, processing techniques, and dietary strategies
BACKGROUND: Antinutritional factors (antinutrients) are bioactive compounds in plant-derived foods that can impair nutrient absorption and reduce the bioavailability of proteins, carbohydrates, and essential minerals. Major representatives include phytates, oxalates, lectins, tannins, saponins, and enzyme inhibitors, which have been associated with adverse nutritional outcomes through interference with nutrient uptake.
Digital intelligence for cardiometabolic health management in older adults: protocol for a community-based prospective cohort study
BACKGROUND: Cardiovascular diseases (CVDs) represent a significant cause of morbidity and mortality among older adults in China, exerting a substantial influence on their quality of life and life expectancy. The country’s ageing population is predicted to intensify this burden, underscoring the need for the development of innovative and effective management strategies.
G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation
No abstract
Tangles and Plaques: A deep dive into the pathological hallmarks of Alzheimer's disease
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder. In AD, there is a gradual impairment of memory and cognitive function that interferes with daily living. The pathophysiology of AD revolves around complex interactions between amyloid-β (Aβ) overproduction and accumulation, followed by tau hyperphosphorylation, which together promote a cascade of neuronal dysfunction and degeneration. AD has two forms, sporadic and familial, with genetic variants such as triggering...