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The disease continues to spread in several African countries, but cases are down after an explosion in 2024

In Alaska’s Salmon River, leached metals reach levels that are toxic for aquatic life

Ageing is one of the most significant risk factors for heart disease; however, it is still not clear how the human heart changes with age. Taking advantage of a unique set of pre-mortem, cryopreserved, non-diseased human hearts, we performed omics analyses (transcriptomics, proteomics, metabolomics, and lipidomics), coupled with biologically informed computational modelling in younger (≤ 25 years old) and older hearts (≥ 50 years old) to describe the molecular landscape of human cardiac ageing....

Almost half of pregnant women globally are currently estimated to be overweight or obese. Rates of childhood obesity are also on the rise, in part because of increased consumption of dietary saturated fats. However, the long-term effect of peri- and postnatal high fat (HF) feeding on cognitive function and neuronal expression has not yet been investigated. Male and female C57BL/6J mice born to dams fed a control (C) or high fat (HF) diet were themselves fed either the C or HF diet, generating...

Cell states evolve through the combined activity of signaling pathways and gene networks. While transcription factors can direct cell fate, these factors rely on a receptive cell state. How signaling levels contribute to the emergence of receptive cell states remains poorly defined. Using a well-defined model of direct conversion, we examined how levels of the mitogen-activated protein kinase (MAPK)-activating oncogene HRAS^(G12V) influence direct conversion of primary fibroblasts to induced...

The physiological decline associated with aging is often accompanied by a progressive deterioration in cognitive processing abilities driven by a series of cellular dysfunctions that remain poorly understood. In the hippocampus, a critical area for learning and memory, aging affects the functional expression of ionotropic and metabotropic receptors, including the metabotropic glutamate receptors (mGluRs). mGluRs play a critical role in multiple cellular functions, including modulation of ion...

Visual motion perception declines during natural aging in most animals including humans. Edible berries of blackcurrant (BC) and its extracted anthocyanins (BCAs) have beneficial effects on human eyes. However, the effect of BCAs on the perception of moving objects and other dynamic visual patterns remains unknown. In the current study, we investigated whether BCAs improve visual movement perception in aging mice. The aging mice were fed either a standard diet or a standard diet containing BC....

CONCLUSIONS: Co-occurrence of low IC and frailty was significantly associated with poor self-rated health. These findings suggest that considering IC and frailty may enhance understanding of self-rated health in later life.

CONCLUSIONS: The points-program has the potential to promote not only the immediate outcomes it targets but also other domains of health and well-being outcomes through increased social interaction and healthy behaviors.

Study in fruit flies sheds light on quirk of insect fertility