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Traditional Disease Risk Factors Outperform Epigenetic Clocks as Predictors of Non-Communicable Disease Morbidity in a Middle-Aged Cohort
DNA methylation-based epigenetic clocks have been highlighted as promising biomarkers of ageing, and they have been shown to robustly predict morbidity and mortality. However, current literature is lacking a formal analysis of the increased prediction accuracy, or the added value, of the epigenetic clocks over traditional risk factors, such as body composition, smoking, or alcohol consumption, in predicting common chronic diseases. Here, we have compared the most commonly used epigenetic clocks...
Age-associated DNA methylation patterns in mouse blood and tail: feasibility of tissue-specific epigenetic clock development
Aging is accompanied by widespread remodeling of DNA methylation (DNAm), which can be leveraged to build epigenetic clocks. In mice, most DNAm clocks rely on internal organs or terminal tissues, limiting longitudinal studies. Here, we compared age-associated DNAm patterns in matched blood and tail-an easily accessible but underexplored tissue-and evaluated both as substrates for tissue-specific DNAm age prediction. Matched blood and tail were collected from male C57BL/6N Per2::Luc mice aged...
NAD(+) modulates REST isoform expression and its downstream mitophagy in Alzheimer's disease
Repressor Element 1-Silencing Transcription factor (REST) emerges as a metabolism-sensitive transcriptional hub that supports basal mitophagy, mitochondrial quality, and synaptic function in neurons. In Alzheimer's disease, REST becomes mislocalized and functionally impaired, coinciding with early defects in mitochondrial quality control. Activation of the NAD^(+) -SIRT1 axis enhances REST nuclear activity, restores its mitochondrial and neuroprotective gene programs, and attenuates pathological...
Distribution, inequalities and associated factors of unmet medical needs among older adults: evidence from the national health service survey
CONCLUSIONS: The UMNs of the older adults and the potential threat to inequalities require the attention of policymakers. Interventions should focus on improving access to medical services, with a particular emphasis on addressing the needs of vulnerable populations.
Building Sustainable Access to Home- and Community-Based Services for Rural Veterans and Older Americans
No abstract
ZBTB7A-mediated regulation of astrocytic glycolysis in neurodegenerative diseases: insights from literature review and bioinformatics prediction
The incidence of neurodegenerative diseases, including Alzheimer's disease (AD), continues to increase with the extension of human lifespan. However, their pathogenesis remains incompletely understood. Altered energy metabolism, particularly glucose metabolism involving glycolysis and oxidative phosphorylation, is widely recognized as an early pathological feature of neurodegenerative diseases. Astrocytes, the most numerous and widely distributed functional cells in the central nervous system...
Daily briefing: Mutation lets octopuses make proteins with precision
Author Correction: A T<sub>reg</sub>-specific long noncoding RNA maintains immune-metabolic homeostasis in aging liver
‘This time, it’s the other way around’: how Indonesia is reclaiming the science of human history
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Graduating without a thesis: meet the people getting ‘practical’ PhDs in China
Found: the toxic killer that caused an ocean catastrophe
Pair of ‘super-puff’ planets are lighter than candyfloss
Bacteria sense virus-induced genome degradation via methylated mononucleotides
Science, Ahead of Print.
Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion
Science, Ahead of Print.
Vicinal disubstitution of alkyl C–X synthons via alkene radical cation generation
Science, Ahead of Print.
Autonomous biomedical research with an artificial intelligence agent
Science, Ahead of Print.
A vitamin A discovery is changing what scientists know about vision
A surprising discovery is reshaping scientists' understanding of how humans develop sharp central vision before birth. Instead of blue cone cells migrating away from the retina's center, the study found they transform into red and green cones under the influence of vitamin A-related signals and thyroid hormones. The findings could improve lab-grown retinal tissue and lay the groundwork for future cell therapies to restore vision lost to age-related eye diseases.
The Ozempic and Wegovy mistake sending thousands to poison control
Poison control calls involving semaglutide (Ozempic and Wegovy) soared after the drug was approved for weight management, with researchers linking the increase to accidental dosing mistakes rather than intentional misuse. Simple education about proper weekly dosing and gradual dose increases could help prevent many of these avoidable incidents.
Harvard scientists turn a silicon chip into a DNA writing machine
Scientists have created a silicon chip that can write dozens of DNA sequences simultaneously using electricity and water-based enzymes, offering a cleaner alternative to conventional DNA manufacturing. The breakthrough could eventually support portable DNA-writing devices and even massive DNA data storage, although new chemistry will be needed to scale the technology further.