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Why do curling stones slide across ice the way they do?
Gel helps mini spinal cords to heal from injury
AI is threatening science jobs. Which ones are most at risk?
Are obesity drugs causing a severe complication? What the science says
Runaway black hole leaves a trail of stars
Briefing chat: How hovering bumblebees keep their cool
Author Correction: Natural behaviour is learned through dopamine-mediated reinforcement
The 201 Trial: a placebo-controlled randomized phase 2 study of safety and tolerance of the c-Abl kinase inhibitor risvodetinib in untreated Parkinson’s disease
Five ways increased militarization could change scientific careers
Publisher Correction: PtdIns(3,5)P<sub>2</sub> is an endogenous ligand of STING in innate immune signalling
Super-sticky feet help a robot to climb the walls
A shocking explanation for tape’s distinctive screech
Fast-moving cracks in tape’s adhesive layer produce shock waves that make the stuff sing as it unrolls
Journal giant Elsevier unveiled an AI tool that scans millions of paywalled papers. Is it worth it?
First-of-its-kind product raises questions about costs, access, and equity
NIH research grant funding rates plummeted in 2025
Agency acknowledges young investigators are losing out as result of multiyear funding policy imposed by White House
Trump’s NSF pick is a stranger to its research community
Jim O’Neill will need to build ties, say former agency leaders
New energy department science advisory committee reflects Trump’s AI push
DOE’s 21-member Office of Science Advisory Committee is well-qualified but lacks disciplinary breadth, observers say
The retinal nerve fiber layer mean thickness in patients with early Parkinson's disease reflects striatal dopamine function
CONCLUSIONS: The strength and significance of our study are that it is the first to indicate, on the basis of the α-syn mechanism, that the mean RNFL thickness partly reflects striatal dopamine uptake in the brain, suggesting that the mean RNFL thickness may have a certain value for the early diagnosis of PD.
Liver exerkine reverses aging- and Alzheimer's-related memory loss via vasculature
Blood factors transfer the benefits of exercise to the aged brain independent of physical activity. Here, we show that the liver-derived exercise factor (exerkine) glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1), a GPI-degrading enzyme, reverses aging- and Alzheimer's-related memory loss by targeting the brain vasculature. GPLD1 has the potential to cleave over 100 putative GPI-anchored proteins, necessitating the identification of downstream targets that mediate cognitive...
Brain-wide mapping of oligodendrocyte organization, oligodendrogenesis, and myelin injury
Insulating sheaths of myelin accelerate neuronal communication in the mammalian brain. Oligodendrocytes that produce myelin are generated throughout life to gradually increase myelin coverage, but these dynamics have not been defined brain-wide across the lifespan. We developed a cellular mapping pipeline involving tissue clearing, lightsheet microscopy, and AI-assisted analysis to identify the precise location of millions of oligodendrocytes and assess regional myelin density in the mouse...
Vulnerability of short-term memory in a mouse model of Alzheimer's disease
Interference from distracting stimuli renders short-term memory vulnerable. While behavioral evidence suggests short-term memory deficits in Alzheimer's disease (AD), the underlying neural mechanisms remain poorly understood. Using a mouse model of AD (APP-KI), we identified increased susceptibility of short-term memory to sensory perturbations. Simultaneous two-photon calcium imaging across eight cortical regions during a delayed-response task showed that distractors disrupted neural...