Skip to main content

Aggregator

A genome-wide association study identifies Asian-specific genetic susceptibility for epigenetic age acceleration

2 months 1 week ago
Genome-wide association studies (GWASs) have been performed on multiple epigenetic clocks to understand the genetic underpinnings of epigenetic age acceleration (EAA). To explore ethnic differences and individual variability in Asian populations, we conducted a GWAS of EAA using multiple epigenetic clocks in the Korean population. Genome-wide single-nucleotide polymorphism (SNP) and methylation data were obtained from 1962 Korean individuals. Five epigenetic clocks (Hannum, DNAm PhenoAge,...
Kwangyeon Oh

Impact of informal caregiving at older ages on loneliness and social networks in Singapore

2 months 1 week ago
CONCLUSION: Older adult informal caregivers are a vulnerable subgroup at a higher risk of loneliness compared to non-caregivers. Although informal caregiving does not impact social networks, older adult informal caregivers experience loneliness, i.e., a perceived discrepancy between their actual and desired social relationships. Our study suggests the need for further examination of the underlying mechanisms between informal caregiving at older ages and loneliness, as well as a special focus on...
Ting Yong

Association between shift work and brain age gap: a neuroimaging study using MRI-based brain age prediction algorithms

2 months 1 week ago
CONCLUSION: These findings demonstrate that shift work is associated with accelerated apparent brain aging, even after controlling for systematic model bias and demographic covariates. The observed reduction in BAG with extended shift work exposure may reflect adaptive or selective effects, emphasizing the need for longitudinal studies to clarify these mechanisms. This research highlights the importance of incorporating occupational exposures in neuroimaging and brain health investigations.
Youjin Kim

Influence of biological sex on neuroinflammatory dynamics in the aging brain

2 months 1 week ago
The aging brain undergoes complex neuroinflammatory changes that are increasingly recognized as contributing factors to the development and progression of neurodegenerative diseases. Emerging research reveals that biological sex profoundly shapes these neuroinflammatory dynamics, resulting in distinct trajectories of immune function, glial activity, and neural vulnerability in males and females. This mini-review focuses on recent advances in understanding the interplay of hormonal, genetic, and...
Ludmila Müller