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Controlling the helicity of light by electrical magnetization switching
High-fidelity spin qubit operation and algorithmic initialization above 1 K
Structural basis of exoribonuclease-mediated mRNA transcription termination
Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity
TRBC1-targeting antibody–drug conjugates for the treatment of T cell cancers
Optomechanical realization of the bosonic Kitaev chain
Five million years of Antarctic Circumpolar Current strength variability
The HEAT repeat protein HPO-27 is a lysosome fission factor
Formation of memory assemblies through the DNA-sensing TLR9 pathway
CGRP sensory neurons promote tissue healing via neutrophils and macrophages
A global timekeeping problem postponed by global warming
No sweat: Moisture-wicking device keeps wearable-tech dry
Cancer-vaccine trials give reasons for optimism
Video: Cancer-busting vaccines
<i>Nature</i> is committed to diversifying its journalistic sources
Tweeting your research paper boosts engagement but not citations
Smallpox may be gone but U.S. should better prepare for its return, report says
Improved vaccines, drugs, and diagnostics needed for old foe, and could also help against new ones like the mpox virus, panel concludes
Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice
Mutations in the gene encoding the lysosomal enzyme glucocerebrosidase (GCase) are responsible for Gaucher disease (GD) and are considered the strongest genetic risk factor for Parkinson's disease (PD) and Lewy body dementia (LBD). GCase deficiency leads to extensive accumulation of glucosylceramides (GCs) in cells and contributes to the neuropathology of GD, PD, and LBD by triggering chronic neuroinflammation. Here, we investigated the mechanisms by which GC accumulation induces...
Autophagy maintains endosperm quality during seed storage to preserve germination ability in Arabidopsis
To preserve germination ability, plant seeds must be protected from environmental stresses during the storage period. Here, we demonstrate that autophagy, an intracellular degradation system, maintains seed germination ability in Arabidopsis thaliana. The germination ability of long-term (>5 years) stored dry seeds of autophagy-defective (atg) mutant and wild-type (WT) plants was compared. Long-term stored (old) seeds of atg mutants showed lower germination ability than WT seeds, although...
SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic modality of autophagy for secretion of vesicular cargo, regulates neuroinflammation-mediated neurodegeneration via SKA2 and FKBP5 signaling. SKA2 inhibits SA-dependent IL-1β release by counteracting FKBP5 function. Hippocampal Ska2 knockdown in male mice...