Skip to main content

Aggregator

Growing pains

2 months 1 week ago
Science, Volume 391, Issue 6782, Page 322-322, January 2026.
Alanna Lecher

The photohydrolysis of furans

2 months 1 week ago
Science, Volume 391, Issue 6782, Page 267-274, January 2026.
Nils Frank, Moreshwar B. Chaudhari, Markus Leutzsch, Benjamin Helmich-Paris, Paolo Cleto Bruzzese, Darryl Nater, Nils Nöthling, Alexander Schnegg, Siegfried R. Waldvogel, Benjamin List

Stability of non-canonical nucleic acid structure as a potential modulator of cell fate

2 months 1 week ago
Cellular morphological changes occur during cell life and diseases, such as senescence and cancer. Although the cellular conditions should be varied with the morphology changes, there have been no attempts to understand the cellular morphological changes by focusing on the intracellular molecular environment and elucidating the behaviour of nucleic acids. Nucleic acids can form hierarchical secondary and higher-order structures due to intermolecular interactions and other factors. Additionally,...
Shuntaro Takahashi

Visualization and quantification of rDNA instabilities in mammalian cells and mouse models

2 months 1 week ago
Ribosomal DNA (rDNA) encodes the 18S, 5.8S, and 28S rRNA, accounting for ∼70% of cellular transcription. Despite its essential role and links to cancer and aging, quantifying rDNA instability in mammals remains challenging due to its repetitive organization and inherent heterogeneity. Here, we developed a murine rDNA FISH probe and genomic tools tailored for laboratory mouse strains. The results confirmed rDNA cluster locations, revealed substantial inter- and intra-strain as well as...
Xiaolu Zhu