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Fall Books 2025

2 months 1 week ago
Science, Volume 389, Issue 6766, Page 1180-1186, September 2025.
Margaret Linak, Adam Shapiro, Meryleen Mena, Carolyn Wong Simpkins, Amit Chandra, Lisa Poggiali, Bradley G. Lusk, Josh Trapani and Rosemarie Szostak

The how and why of sleep: Motor theory and catecholamine hypothesis

2 months 1 week ago
Sleep entails profound changes in the brain and body, marked by altered states of consciousness and reduced somatic and autonomic motor activity. Regarding "how" sleep is regulated, whole-brain screening revealed large sleep-control networks spanning the forebrain, midbrain, and hindbrain. We unify diverse experimental evidence under a "motor theory," in which the sleep-control mechanism is integral to somatic and autonomic motor circuits. Regarding the "why" question, sleep deprivation impairs...
Chenyan Ma

A health promotion behavior intervention for migrant older adults: a randomized controlled trial

2 months 1 week ago
CONCLUSIONS: The BCW-based health promotion intervention effectively enhanced the well-being of migrant older adults by addressing their unique needs. The findings highlight the potential of tailored, multidimensional interventions to support this vulnerable population. Future research should explore long-term effects and cost effectiveness for broader implementation.
Na Zhou

Identifying novel modifiable risk factors for ischemic stroke through phenome-wide association study and Mendelian randomization analyses in a large-scale prospective cohort

2 months 1 week ago
Despite extensive research, significant uncertainty remains regarding the associations between various risk factors and ischemic stroke (IS). This study aimed to systematically identify and validate a broad range of potential modifiable risk factors for IS. Utilizing genetic and phenotypic data from the UK Biobank (UKB; N = 418,236), we conducted a phenome-wide association study (PheWAS) and Cox regression analysis to identify modifiable factors across sociodemographics, physical measures,...
Siyu Wu