Aggregator
Asymmetric life-history trade-offs shape sex-biased longevity patterns
Sex differences in ageing and lifespan are widespread across taxa, yet their evolutionary causes remain debated. A leading hypothesis proposes that such differences arise adaptively from sex-specific life-history trade-offs, but formal theoretical support is lacking. We therefore develop a mathematical model to examine how these trade-offs shape lifespan evolution across ecological and mating system contexts. Under monogamy, individuals optimise a survival-reproduction trade-off, mediated by...
Two-photon in vivo imaging reveals cell type-specific mitophagy dynamic changes in mouse somatosensory cortex during aging
Mitochondrial homeostasis is majorly maintained through mitochondrial autophagy (mitophagy). Recent research highlights the region- and cell type-specific nature of mitophagy during brain aging; however, these dynamics have largely remained unexplored in living brains. To address this gap, we conducted two-photon mt-Keima imaging in somatosensory cortical neurons and astrocytes in behaving male mice across two age groups, including 2-3-month-old (early-aged) and 18-20-month-old (old-aged) mice....
Loss of Brain-Derived Estrogen Is Associated With Sex- and Age-Dependent Alterations in Memory, Affective Behavior, and Hippocampal Extracellular Matrix Gene Expression
Nearly two-thirds of Americans with Alzheimer's disease (AD) are women. Prior research suggested that women with AD have lower brain estrogen levels than those without AD. However, how estrogen deficiency modulates this sex-based difference in AD vulnerability is not well understood. Aromatase, the key enzyme for estrogen biosynthesis, is expressed in both neurons and astrocytes of the brain, including the hippocampus. This study aims to assess the mechanistic link between brain-selective...
Undermining older adults' autonomy impairs physical health: longitudinal evidence and psychological mechanisms
CONCLUSIONS: Undermined autonomy poses a significant independent threat to older adults' physical health and longevity. This detrimental effect is partly driven by the internalization of negative stereotypes regarding older adults' competence. Findings underscore the critical need to protect older adults' autonomy and challenge the infantilizing attitudes that often rationalize paternalistic practices.
Loss of Brain-Derived Estrogen Is Associated With Sex- and Age-Dependent Alterations in Memory, Affective Behavior, and Hippocampal Extracellular Matrix Gene Expression
Nearly two-thirds of Americans with Alzheimer's disease (AD) are women. Prior research suggested that women with AD have lower brain estrogen levels than those without AD. However, how estrogen deficiency modulates this sex-based difference in AD vulnerability is not well understood. Aromatase, the key enzyme for estrogen biosynthesis, is expressed in both neurons and astrocytes of the brain, including the hippocampus. This study aims to assess the mechanistic link between brain-selective...
Wikipedia’s gender gap has flipped for one group of scientists
A new study finds women biology faculty are now more likely than men to have a biography on the popular website