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Scattershot vaccination fails to slow mpox spread in Congo
Limited vaccine doses weren’t used strategically, WHO analysis finds
How do research careers compare across countries? New global database has some answers
Online tool from the Research and Innovation Careers Observatory allows users to compare salary, typical career destinations, and more
Deciphering how dog roses with an odd chromosome copy number sexually reproduce
Ageing is linked to inflammation — but only in the industrialized world
Trump team axes contracts with publishing giant Springer Nature
Stare into a whale’s colossal eye — June’s best science images
Natural nappers: monitoring the sleeping patterns of wild orangutans
Nonuniversality of inflammaging across human populations
Obesity drugs made in China could power next wave of treatments
’We couldn’t live without it’: the UCSC Genome Browser turns 25
I pioneered my country’s newborn health-screening programme
Epigenetic erosion of H4K20me1 induced by inflammation drives aged stem cell ferroptosis
A TFEB–TGFβ axis systemically regulates diapause, stem cell resilience and protects against a senescence-like state
Clusterin drives myeloid bias in aged hematopoietic stem cells by regulating mitochondrial function
What do dolphins talk about? One biologist is trying to listen in
If you’re a US researcher, now is the time to establish a plan B
EPA employees accuse Trump officials of undermining the agency’s mission
“Declaration of Dissent” denounces partisan messaging, rollback of environmental regulations, and dismantling of science office, among other concerns
Scientists identify culprit behind biggest-ever U.S. honey bee die-off
USDA research points to viruses spread by pesticide-resistant mites, indicating a worrying trend
Movement-responsive deep brain stimulation for Parkinson's disease using a remotely optimized neural decoder
Deep brain stimulation (DBS) has garnered widespread use as an effective treatment for advanced Parkinson's disease. Conventional DBS (cDBS) provides electrical stimulation to the basal ganglia at fixed amplitude and frequency, yet patients' therapeutic needs are often dynamic with residual symptom fluctuations or side effects. Adaptive DBS (aDBS) is an emerging technology that modulates stimulation with respect to real-time clinical, physiological or behavioural states, enabling therapy to...
A Drosophila single-cell 3D spatiotemporal multi-omics atlas unveils panoramic key regulators of cell-type differentiation
The development of a multicellular organism is a highly intricate process tightly regulated by numerous genes and pathways in both spatial and temporal manners. Here, we present Flysta3D-v2, a comprehensive multi-omics atlas of the model organism Drosophila spanning its developmental lifespan from embryo to pupa. Our datasets encompass 3D single-cell spatial transcriptomic, single-cell transcriptomic, and single-cell chromatin accessibility information. Through the integration of multimodal...