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Elastin-derived extracellular matrix fragments drive aging through innate immune activation

12 hours 14 minutes ago
The roles of cells in systemic aging have been systematically investigated, while the roles of the extracellular matrix (ECM) and its degradation have been largely overlooked. Herein, we show that the serum contents of elastin-, hyaluronic acid- and fibronectin-derived fragments are all positively correlated with age. Elastin-derived fragments exhibited the most potent lifespan-shortening effects in mice and a positive correlation with various aging indicators in a human cohort (n = 1,068)....
Junzhi Yi

Surface-based morphometry reveals divergent aging trajectories in veterans with and without traumatic brain injury

12 hours 14 minutes ago
This study investigates how traumatic brain injury (TBI) alters cortical aging by comparing cortical thickness (CT) and surface area (SA) in 34 brain regions between TBI survivors and age-matched controls. Using a cross-sectional retrospective design, 105 Vietnam Veterans (32 with moderate-to-severe TBI, 73 controls) were analyzed via surface-based morphometry. Principal Component Analysis (PCA) reduced dimensionality, and Multivariate Analysis of Covariance tested group differences while...
Michelle C Eliason

Low protein-induced-FGF-21 signaling remodels adipose tissue on reduced markers of senescence during aging

12 hours 14 minutes ago
Cellular senescence and metabolic impairment occur during aging, with adipose tissue decline playing a key role in this process. Furthermore, the detriments of aging on adipose tissue function are further exacerbated by obesity. Dietary protein restriction (DPR), without reducing calorie intake, protects against age-related metabolic decline and extends lifespan through the metabolic hormone FGF21. Here, we demonstrate that protein restriction significantly decreases pro-oncogenic and...
Jose G Godoy-Lugo

Unraveling the mysteries of Hutchinson-Gilford progeria syndrome: a comprehensive review of LMNA gene mutations

12 hours 14 minutes ago
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare and fatal disorder characterized by premature aging, predominantly resulting from mutations in the LMNA gene, which lead to the accumulation of a truncated and aberrant progerin protein. This paper offers an in-depth review of the fundamental theories, epidemiology, pathological mechanisms, and treatment strategies associated with HGPS as caused by LMNA gene mutations. Furthermore, it examines the current challenges in clinical translation,...
Xiaoqing Zhou

Multimorbidity and its association with health-related quality of life among older adults in india: a cross-sectional analysis of LASI wave-1

12 hours 14 minutes ago
CONCLUSIONS: This study found that multimorbidity significantly reduces HRQoL among older adults in India, with women, individuals of lower socioeconomic status, and those reporting poor self-rated health experiencing the most significant burden. These findings highlight the need for gender-sensitive, equity-focused public health strategies aimed at managing chronic conditions and improving quality of life among the ageing population in India.
Vasim Ahamad

Psychological resources and illness recovery in later life: independent associations of positive mental health and attitudes to aging

12 hours 14 minutes ago
CONCLUSIONS: High positive mental health (flourishing) and positive attitudes to aging were significantly associated with better health and illness recovery outcomes among older adults. These findings emphasize the potential value of integrating positive mental health and positive attitudes to aging in clinical assessment and intervention. Further investigation of the biopsychosocial model incorporating positive psychology principles is warranted to elucidate a bio-positive-psychosocial medical...
Jianqian Wu

Changes in service use and unmet needs in home- and community- based services in the United States during the COVID-19 pandemic

12 hours 14 minutes ago
CONCLUSIONS: During the PHE, simultaneous increase in services use and unmet service needs for some HCBS (e.g. personal care) suggests that temporary PHE measures taken were insufficient to offset the demand for those services. For caregiver respite/support, increased service use and decreased unmet service needs suggests that the temporary PHE measures for caregiver support may have offset a rise in service demand. These findings can inform evaluations of temporary PHE policies for HCBS and...
Romil R Parikh

The relationship between cognitive impairment and quality of life in rural older adults with chronic diseases-parallel mediating effects of depressive symptoms and frailty

12 hours 14 minutes ago
CONCLUSIONS: We found that cognitive impairment not only directly affects the quality of life of rural older adults with chronic diseases but also indirectly affects them through depressive symptoms and frailty. To improve the quality of life of rural older adults with chronic diseases, we should pay attention to their cognitive impairment. Simultaneously, efforts should focus on alleviating depressive symptoms and frailty in this population. Strengthening the management of chronic diseases is...
Haoqi Li