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Prehistoric camel art pointed to precious water sources in the Arabian Desert
Hunter-gatherers may have used the engravings to find water 12,000 years ago
Elastin-derived extracellular matrix fragments drive aging through innate immune activation
The roles of cells in systemic aging have been systematically investigated, while the roles of the extracellular matrix (ECM) and its degradation have been largely overlooked. Herein, we show that the serum contents of elastin-, hyaluronic acid- and fibronectin-derived fragments are all positively correlated with age. Elastin-derived fragments exhibited the most potent lifespan-shortening effects in mice and a positive correlation with various aging indicators in a human cohort (n = 1,068)....
Toward new clinical evaluation models for skin longevity: the need for predictive and accelerated approaches
No abstract
Surface-based morphometry reveals divergent aging trajectories in veterans with and without traumatic brain injury
This study investigates how traumatic brain injury (TBI) alters cortical aging by comparing cortical thickness (CT) and surface area (SA) in 34 brain regions between TBI survivors and age-matched controls. Using a cross-sectional retrospective design, 105 Vietnam Veterans (32 with moderate-to-severe TBI, 73 controls) were analyzed via surface-based morphometry. Principal Component Analysis (PCA) reduced dimensionality, and Multivariate Analysis of Covariance tested group differences while...
Low protein-induced-FGF-21 signaling remodels adipose tissue on reduced markers of senescence during aging
Cellular senescence and metabolic impairment occur during aging, with adipose tissue decline playing a key role in this process. Furthermore, the detriments of aging on adipose tissue function are further exacerbated by obesity. Dietary protein restriction (DPR), without reducing calorie intake, protects against age-related metabolic decline and extends lifespan through the metabolic hormone FGF21. Here, we demonstrate that protein restriction significantly decreases pro-oncogenic and...
Unraveling the mysteries of Hutchinson-Gilford progeria syndrome: a comprehensive review of LMNA gene mutations
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare and fatal disorder characterized by premature aging, predominantly resulting from mutations in the LMNA gene, which lead to the accumulation of a truncated and aberrant progerin protein. This paper offers an in-depth review of the fundamental theories, epidemiology, pathological mechanisms, and treatment strategies associated with HGPS as caused by LMNA gene mutations. Furthermore, it examines the current challenges in clinical translation,...
Association between nutritional status and mental health among elderly in community health screenings: a cross sectional study
No abstract
Exploring long-term recovery and community health management: a qualitative study of older adults and caregivers' experiences post COVID-19 in the Republic of Ireland
CONCLUSION: Older adults report their recovery from COVID-19 infection but note significant long-term effects on their health and well-being resulting in an increased need for formal and informal supports in the community.
Effects of intrinsic foot muscle training combined with the lower extremity resistance training on postural stability in older adults: a randomised controlled trial
CONCLUSION: Compared with regular intervention grogramme, additional short-foot training militated extra effect on improving static postural stability, mobility, foot muscle strength and morphology in the elderly.
Multimorbidity and its association with health-related quality of life among older adults in india: a cross-sectional analysis of LASI wave-1
CONCLUSIONS: This study found that multimorbidity significantly reduces HRQoL among older adults in India, with women, individuals of lower socioeconomic status, and those reporting poor self-rated health experiencing the most significant burden. These findings highlight the need for gender-sensitive, equity-focused public health strategies aimed at managing chronic conditions and improving quality of life among the ageing population in India.
Mitigation of detraining effects: physical activity improves protein profile and physical function of aged amid COVID-19
CONCLUSIONS: Overall, the study suggests that resuming combined exercise training partially mitigated the detraining-induced impairment in metabolic and physical capacities among older adults.
A Delphi consensus-based frailty screening scale for community-dwelling older adults in China
CONCLUSIONS: The Frailty Screening Scale (FSS) demonstrates good content basis and contextual adaptability as a brief frailty screening tool for community-dwelling older adults in China.It may serve as a complementary tool alongside existing frailty assessment instruments.
Psychological resources and illness recovery in later life: independent associations of positive mental health and attitudes to aging
CONCLUSIONS: High positive mental health (flourishing) and positive attitudes to aging were significantly associated with better health and illness recovery outcomes among older adults. These findings emphasize the potential value of integrating positive mental health and positive attitudes to aging in clinical assessment and intervention. Further investigation of the biopsychosocial model incorporating positive psychology principles is warranted to elucidate a bio-positive-psychosocial medical...
Changes in service use and unmet needs in home- and community- based services in the United States during the COVID-19 pandemic
CONCLUSIONS: During the PHE, simultaneous increase in services use and unmet service needs for some HCBS (e.g. personal care) suggests that temporary PHE measures taken were insufficient to offset the demand for those services. For caregiver respite/support, increased service use and decreased unmet service needs suggests that the temporary PHE measures for caregiver support may have offset a rise in service demand. These findings can inform evaluations of temporary PHE policies for HCBS and...
The relationship between cognitive impairment and quality of life in rural older adults with chronic diseases-parallel mediating effects of depressive symptoms and frailty
CONCLUSIONS: We found that cognitive impairment not only directly affects the quality of life of rural older adults with chronic diseases but also indirectly affects them through depressive symptoms and frailty. To improve the quality of life of rural older adults with chronic diseases, we should pay attention to their cognitive impairment. Simultaneously, efforts should focus on alleviating depressive symptoms and frailty in this population. Strengthening the management of chronic diseases is...