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NSF could be moving down the street
Government sets requirements for new space that sound like nearby patent office campus
Exploring efficient and effective mammalian models for Alzheimer's disease
The aim of this study was to explore and discuss efficient and effective mammalian models for Alzheimer's disease (AD). In this study, efficient AD models are characterized by a small body size, a short lifespan, and rapid development of the main pathology including amyloid plaque formation. Effective AD models are expected to exhibit not only the main pathology, but also co-pathology associated with other neurodegenerative diseases (e.g., Lewy body dementia), systemic disturbances such as...
Effects of walking training with and without a robot and standard care on clinical and mobility outcomes: A randomized clinical trial in acute ischemic stroke patients
CONCLUSION: Older adults shortly after an ischemic stroke can quickly learn to walk with a soft robot and retain substantial clinical and mobility improvements at follow-up.
The National Dementia Workforce Study: Development of Questionnaires for Home Care, Assisted Living, and Nursing Home Settings
The growing aging population and rising prevalence of dementia are driving increased demand for long-term care services and supports in the United States. People with dementia require substantial support and care, often from direct care workers in private homes, assisted living communities, and nursing homes. Despite their crucial role, these workers receive highly variable training, particularly in dementia care, and face significant work-related challenges including stress, injury, and...
Contrast Sensitivity Impairment Is Associated With Limitations of Physical Functioning and Activities of Daily Living Among Older Adults
Purpose: Contrast sensitivity (CS), the ability to see objects against their background, is an important component of visual function. The effect of contrast sensitivity impairment (CSI) on physical functioning (PF) is not well documented. Methods: This study obtained data from the Aging, Demographics, and Memory Study. Baseline CS was measured, and self-reported PF, activities of daily living (ADLs), and instrumental activities of daily living (IADLs) were assessed biennially. Results: The...
Therapeutic restoration of mitochondria-endoplasmic reticulum cross talk for osteoarthritis
Osteoarthritis is a prevalent joint disease in the aging population. The hallmark of osteoarthritis is the degeneration of the joint cartilage, characterized by changes in chondrocytes including mitochondrial dysfunction. However, the precise mechanisms of how this affects chondrocyte homeostasis and whether such processes can be explored as therapeutic targets for osteoarthritis remain unclear. Here, we show that impaired mitochondrial function and disrupted cartilage matrix metabolism due to...
Mammalian conservation of endogenous G-quadruplex reveals their associations with complex traits
CONCLUSIONS: Our study highlights the important regulatory functions and close association with complex human traits of human eG4s that are highly conserved in the mammalian lineage.