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Integrating multiple evidence streams to understand insect biodiversity change
Science, Volume 388, Issue 6742, April 2025.
Human high-order thalamic nuclei gate conscious perception through the thalamofrontal loop
Science, Volume 388, Issue 6742, April 2025.
A geological timescale for bacterial evolution and oxygen adaptation
Science, Volume 388, Issue 6742, April 2025.
Osteoarthritis treatment via the GLP-1–mediated gut-joint axis targets intestinal FXR signaling
Science, Volume 388, Issue 6742, April 2025.
Homogeneous-heterogeneous bifunctionality in Pd-catalyzed vinyl acetate synthesis
Science, Volume 388, Issue 6742, April 2025.
Exogenous RNA surveillance by proton-sensing TRIM25
Science, Volume 388, Issue 6742, April 2025.
Nonlinear sound-sheet microscopy: Imaging opaque organs at the capillary and cellular scale
Science, Volume 388, Issue 6742, April 2025.
Trump administration quashes NIH scientific integrity policy
The now-rescinded policy, designed to protect government researchers from political pressure, strongly endorsed DEI in science
A spatiotemporal cell atlas of cardiopulmonary progenitor cell allocation during development
The heart and lung co-orchestrate their development during organogenesis. The mesoderm surrounding both the developing heart and anterior foregut endoderm provides instructive cues guiding cardiopulmonary development. Additionally, it serves as a source of cardiopulmonary progenitor cells (CPPs) expressing Wnt2 that give rise to both cardiac and lung mesodermal cell lineages. Despite the mesoderm's critical importance to both heart and lung development, mechanisms guiding CPP specification are...
Gas1-high quiescent neural stem cells are multipotent and produce oligodendrocytes during aging and after demyelinating injury
Quiescent neural stem cells (qNSCs) in the adult mouse subventricular zone (SVZ) normally have limited capacity to generate glia. Gliogenic domains are present in both dorsal and ventral SVZ, with the ventral region featuring a subpopulation of Gli1+ qNSCs. In dorsal SVZ, however, the molecular identity and developmental origin of oligodendrogenic qNSCs remains elusive. Here, through single-cell analysis and lineage tracing, we identify an undefined subpopulation of Gas1high qNSCs in dorsal SVZ,...
mRNA binding proteins join the longevity pipeline: Rebuilding muscle through the power of mRNA binding protein therapeutics
Rebuilding muscle through the power of mRNA binding protein therapeutics.
Synaptic deregulation of cholinergic projection neurons causes olfactory dysfunction across five fly Parkinsonism models
The classical diagnosis of Parkinsonism is based on motor symptoms that are the consequence of nigrostriatal pathway dysfunction and reduced dopaminergic output. However, a decade prior to the emergence of motor issues, patients frequently experience non-motor symptoms, such as a reduced sense of smell (hyposmia). The cellular and molecular bases for these early defects remain enigmatic. To explore this, we developed a new collection of five fruit fly models of familial Parkinsonism and...
Decoding brain aging trajectory: predictive discrepancies, genetic susceptibilities, and emerging therapeutic strategies
The global extension of human lifespan has intensified the focus on aging, yet its underlying mechanisms remain inadequately understood. The article highlights aspects of genetic susceptibility to impaired brain bioenergetics, trends in age-related gene expression related to neuroinflammation and brain senescence, and the impact of stem cell exhaustion and quiescence on accelerated brain aging. We also review the accumulation of senescent cells, mitochondrial dysfunction, and metabolic...
Harnessing Immune Rejuvenation: Advances in Overcoming T Cell Senescence and Exhaustion in Cancer Immunotherapy
Immunotherapy has transformed the landscape of cancer treatment, with T cell-based strategies at the forefront of this revolution. However, the durability of these responses is frequently undermined by two intertwined phenomena: T cell exhaustion and senescence. While exhaustion is driven by chronic antigen exposure in the immunosuppressive tumor microenvironment, leading to a reversible state of diminished functionality, senescence reflects a more permanent, age- or stress-induced arrest in...
Neuroprotective role of Hippo signaling by microtubule stability control in <em>Caenorhabditis elegans</em>
The evolutionarily conserved Hippo (Hpo) pathway has been shown to impact early development and tumorigenesis by governing cell proliferation and apoptosis. However, its post-developmental roles are relatively unexplored. Here, we demonstrate its roles in post-mitotic cells by showing that defective Hpo signaling accelerates age-associated structural and functional decline of neurons in Caenorhabditis elegans. Loss of wts-1/LATS, the core kinase of the Hpo pathway, resulted in premature...
NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations
A core facet of the National Institute on Aging's mission is to identify pharmacological interventions that can promote human healthy aging and long life. As part of the comprehensive effort toward that goal, the NIA Division of Biology of Aging established the Caenorhabditis Intervention Testing Program (CITP) in 2013. The C. elegans model (with an ~ 21 day lifespan) has led the field in dissection of longevity genetics and offers features that allow for relatively rapid testing and for the...
Beyond the Binary: Navigating AI’s Uncertain Future in Africa
Science, Volume 388, Issue 6742, April 2025.
Erratum for the Research Article “Whale song shows language-like statistical structure” by I. Arnon et al.
Science, Volume 388, Issue 6742, April 2025.