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Rubin observatory unveils first images taken with its giant mirror and camera
Pictures are a prelude to a transformative, all-sky survey set to begin in months
Killer whales groom each other—with pieces of kelp
In a newly discovered form of social tool use, orcas scratch each other’s backs with seaweed
Cell-Surface LAMP1 is a Senescence Marker in Aging and Idiopathic Pulmonary Fibrosis
The accumulation of senescent cells (SEN) with aging produces a chronic inflammatory state that accelerates age-related diseases. Eliminating SEN has been shown to delay, prevent, and in some cases reverse aging in animal disease models and extend lifespan. There is thus an unmet clinical need to identify and target SEN while sparing healthy cells. Here, we show that Lysosomal-Associated Membrane Protein 1 (LAMP1) is a membrane-specific biomarker of cellular senescence. We have validated...
Sarcopenia and osteoporosis
Sarcopenia and osteoporosis are common, interconnected conditions, in aging populations that lead to increased frailty, disability and a heightened risk of falls and fractures. Sarcopenia is the progressive loss of muscle mass, strength and function, that often coexists with osteoporosis, which is characterized by reduced bone strenght for a decreased bone mineral density (BMD) and altered bone quality. Together, these conditions form a clinical syndrome known as osteosarcopenia. Both disorders...
Obesity and Transition to Assisted Living Services in Older Adults: An Analysis From the National Health and Aging Trends Study
CONCLUSIONS: Overweight, class 1, and class 2 obesity using BMI criteria were protective against TALS. Further study is needed to elucidate the underlying reasons for this protective effect against TALS.
Will Gates and other funders save massive public health database at risk from Trump cuts?
Obesity drugs show promise for treating a new ailment: migraine
Did the US wipe out Iran's nuclear programme? What researchers know
Gating and noelin clustering of native Ca<sup>2+</sup>-permeable AMPA receptors
Modular arene functionalization by differential 1,2-diborylation
Comprehensive evaluation of plasma tau biomarkers for detecting and monitoring Alzheimer’s disease in a multicenter and multiethnic aging population
Sarcosine decreases in sarcopenia and enhances muscle regeneration and adipose thermogenesis by activating anti-inflammatory macrophages
Tardigrade-obsessed: meet the researchers trying to turn water bears into neuroscience models
‘Natural history museums can save the world’: anti-colonialism, conservation and climate change
Medical AI can transform medicine — but only if we carefully track the data it touches
First images from world’s largest digital camera leave astronomers in awe
Ice society: looking for life at unlikely altitudes
What scientists need to know about sharing—and protecting—their published work
With research papers becoming increasingly free to read and use, understanding open-access licenses is key
How many PhDs does the world need? Doctoral graduates vastly outnumber jobs in academia
Multinational evaluation of AnthropoAge as a measure of biological age in the USA, England, Mexico, Costa Rica, and China: a population-based longitudinal study
We validated AnthropoAge, a biological age (BA) metric, for prediction of mortality and age-related outcomes using harmonized data from the US, England, Mexico, Costa Rica, and China. We estimated AnthropoAge and AnthropoAgeAccel as proxies of BA and age acceleration using body mass index and waist-to-height ratio. We compared mortality prediction of AnthropoAge vs. chronological age (CA) using Cox models and assessed its association with age-related outcomes with generalized estimating...