Aging & Longevity

Associations of life's crucial 9 with mortality among older adults with frailty: a prospective cohort study from the NHANES 2007 to 2018

1 week 6 days ago
CONCLUSION: The LC9 score represents an important advancement in assessing mortality risk among frail older adults. This study highlights the need for holistic approaches in aging health assessments and suggests that integrating mental health within cardiovascular metrics may enhance the accuracy of risk predictions.
Shaohua Yan

Analysis of lifespan across Diversity Outbred mouse studies identifies multiple longevity-associated loci

1 week 6 days ago
Lifespan is an integrative phenotype whose genetic architecture is likely to highlight multiple processes with high impact on health and aging. Here, we conducted a genetic mega-analysis of longevity in Diversity Outbred (DO) mice that included 2,444 animals from three independently conducted lifespan studies. We identified eight loci that contributed significantly to lifespan independently of diet and drug treatment in at least one study. One of these loci also influenced lifespan in a...
Martin N Mullis

The PARP inhibitor olaparib promotes senescence in murine macrophages

1 week 6 days ago
Cellular senescence is a multifaceted process involving cell cycle arrest, telomere shortening, and the accumulation of DNA damage associated with aging and cellular stress. It is marked by persistent cell cycle arrest and DNA damage accumulation, and plays an increasingly recognized role in age-related diseases and cancer therapy. Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, is approved for use in ovarian cancer treatment. We hypothesized that olaparib may influence senescence by...
Anna Kieronska-Rudek

Glymphatics and meningeal lymphatics unlock the brain-immune code

2 weeks ago
The central nervous system (CNS) was once perceived as entirely shielded from the immune system, protected behind the blood-brain barrier and thought to lack lymphatic drainage. However, recent evidence has challenged many dogmas in neuroimmunology. Indeed, by means of glymphatics, brain-derived "waste" from deep within the CNS mobilizes toward immunologically active brain borders, where meningeal lymphatic vessels are appropriately positioned to drain antigens from the brain to the periphery....
Min Woo Kim

Microglial and TREM2 dialogues in the developing brain

2 weeks ago
From the migration of precursor cells to the refinement of neural circuits, the immune system plays a critical role in the development of the central nervous system. As the brain resident macrophages, microglia are integral to these processes, influencing key developmental stages and contributing to circuit remodeling. Recent years have brought a wealth of new insights into how microglia regulate key stages of brain development, particularly through their continuous crosstalk with various brain...
Raffaella Morini

The rise of RAS: how gradual oncogene activation shapes the OIS spectrum

2 weeks ago
Excessive levels of oncogenic RAS expression in normal cells trigger reactive cellular senescence, known as oncogene-induced senescence (OIS)-a putative autonomous tumor-suppressive mechanism. However, the monoallelic expression of oncogenic RAS from the endogenous locus often fails to induce senescence, at least in the short term. Consequently, whether robust senescence characterizes the preneoplasia driven by oncogenic RAS under physiological conditions has been debated. A key challenge is the...
Haoran Zhu

Self-cleaning Spiro-OMeTAD via multimetal doping for perovskite photovoltaics

2 weeks ago
Record power conversion efficiencies (PCEs) of perovskite solar cells (PSCs) are usually achieved using organic spiro-OMeTAD. However, conventional doping with hygroscopic dopants (LiTFSI and tBP) leads to compromised device stability. We introduce a synergistic mixed doping strategy that utilizes a combination of metal-TFSI dopants-LiTFSI, KTFSI, NaTFSI, Ca(TFSI)(2), and Mg(TFSI)(2)-to enhance doping efficiency while effectively removing hygroscopic contaminants from the Spiro-OMeTAD solution....
Sisi Wang

Quasi-spatial single-cell transcriptome based on physical tissue properties defines early aging associated niche in liver

2 weeks ago
Aging is associated with the accumulation of senescent cells, which are triggered by tissue injury response and often escape clearance by the immune system. The specific traits and diversity of these cells in aged tissues, along with their effects on the tissue microenvironment, remain largely unexplored. Despite the advances in single-cell and spatial omics technologies to understand complex tissue architecture, senescent cell populations are often neglected in general analysis pipelines due to...
Kwon Yong Tak

Alzheimer's disease and age-related macular degeneration: Shared and distinct immune mechanisms

2 weeks ago
Alzheimer's disease (AD) and age-related macular degeneration (AMD) represent the leading causes of dementia and vision impairment in the elderly, respectively. The retina is an extension of the brain, yet these two central nervous system (CNS) compartments are often studied separately. Despite affecting cognition vs. vision, AD and AMD share neuroinflammatory pathways. By comparing these diseases, we can identify converging immune mechanisms and potential cross-applicable therapies. Here, we...
Oleg Butovsky

Aging inhibits olfactory recovery from traumatic olfactory system injury

2 weeks ago
Although recent advances in treatment of traumatic olfactory dysfunction, which had a low rate of improvement through treatment, have increased the improvement rate in younger patients, it remains low in middle-aged and older patients. Although olfactory function declines with age, its impact on traumatic dysfunction recovery remains unclear. This study was conducted to investigate the effects of aging on olfactory nerve regeneration and olfactory function recovery in an animal model of...
Masayoshi Kobayashi

Health octo tool matches personalized health with rate of aging

2 weeks ago
Medical practice mainly addresses single diseases, neglecting multimorbidity as a heterogeneous health decline across organ systems. Aging is a multidimensional process and cannot be captured by a single metric. Therefore, we assessed global health in longitudinal studies, BLSA (n = 907), InCHIANTI (n = 986), and NHANES (n = 40,790), by examining disease severities in 13 bodily systems, generating the Body Organ Disease Number (BODN), reflecting progressive system morbidities. We used Bayesian...
Sh Salimi

Non-isothermal CO<sub>2</sub> electrolysis enables simultaneous enhanced electrochemical and anti-precipitation performance

2 weeks ago
Electrochemical conversion of CO(2) into fuels represents an important pathway for addressing the challenges of climate change and energy storage. However, large-scale applications remain hindered by the instability and inefficiency of CO(2) reduction systems, particularly under highly alkaline electrolytes and high current densities. One primary obstacle is the cathodic salt precipitation, which hinders mass transfer and blocks active sites limiting the lifespan of these systems. Here, we...
Jieyang Li

Dietary vitamin D intake and 2-year changes in cognitive function in older adults with overweight or obesity and metabolic syndrome

2 weeks ago
The protective role of dietary vitamin D intake on cognitive function is of interest, but evidence remains inconsistent. We aimed to evaluate the association between dietary vitamin D intake and 2-year cognitive changes in older adults at risk of cognitive decline. This longitudinal study comprised 5454 individuals (aged 55-75 years in men and 60-75 years in women) who exhibited overweight/obesity and metabolic syndrome. Data on dietary vitamin D intake was assessed using a validated 143-item...
Héctor Vázquez-Lorente

Group traits moderate the relationship between individual social traits and fitness in gorillas

2 weeks ago
Evidence across a broad range of disciplines has demonstrated how individuals' social environments can impact their health, lifespan, reproduction, and ultimately their evolutionary fitness. Past research has primarily focused on either traits specific to individuals or wider traits of social groups, linking these with a component of fitness. In this study, we examined how both individual- and group-level social traits in 164 wild mountain gorillas combine to influence multiple pathways...
Robin E Morrison

Muscle peripheral circadian clock drives nocturnal protein degradation via raised Ror/Rev-erb balance and prevents premature sarcopenia

2 weeks ago
How central and peripheral circadian clocks regulate protein metabolism and affect tissue mass homeostasis has been unclear. Circadian shifts in the balance between anabolism and catabolism control muscle growth rate in young zebrafish independent of behavioral cycles. Here, we show that the ubiquitin-proteasome system (UPS) and autophagy, which mediate muscle protein degradation, are each upregulated at night under the control of the muscle peripheral clock. Perturbation of the muscle...
Jeffrey J Kelu

Circulating immune cells in cerebral small vessel disease: a systematic review

2 weeks ago
Cerebral small vessel disease (cSVD) refers to all pathologies of the brain's arterioles, capillaries, and venules. cSVD is highly prevalent with ageing and is diagnosed by its characteristic neuro-imaging features. Emerging evidence suggests that circulating immune cells play an important role in cSVD's pathology. However, the specific immune cell populations involved remain poorly understood. This systematic review synthesizes current evidence on circulating immune cells in cSVD and their...
L Van der Taelen

From telomeres and senescence to integrated longevity medicine: redefining the path to extended healthspan

2 weeks ago
Despite significant advances in aging research, translating these findings into clinical practice remains a challenge. Aging is a complex, multifactorial process shaped by many factors including genetic, metabolic, and environmental factors. While medical advancements have extended lifespan, healthspan remains constrained by cellular senescence, telomere attrition, and systemic inflammation-core hallmarks of biological aging. However, emerging evidence suggests that telomere dynamic is not...
Virginia Boccardi

Analyzing different aging theories in the context of the brain: DNA damage, inflammation, redox imbalance, and neurodevelopment intertwine

2 weeks ago
The neuronal tissue is notable for its unique regulation of the immune system, response to DNA damage, endurance against reactive oxygen and nitrogen species, and control of inflammatory pathways. Here, I discuss some uniqueness of the brain's aging process in light of the free radical theory of aging, DNA-damage accumulation, inflammaging, and aging as a consequence of a programmed developmental process. Key points include (i) the resilience of the neuronal tissue to oxidative stress; (ii) the...
Bruno César Feltes

Effects of tetrahydroindenoindole supplementation on metabolism: A systematic review with meta-analysis of rodent-based studies

2 weeks ago
Identifying novel compounds with therapeutic potential is a main area of interest in biomedical research. Tetrahydroindenoindole (THII) has emerged as a compound of interest due to both its antioxidant properties and its action as a pharmacological activator of the enzyme cytochrome b(5) reductase 3. However, there is a lack of comprehensive synthesis of findings, particularly concerning the effects of THII on metabolism in mice under non-disease conditions. This systematic review with...
Miguel Pérez-Rodríguez
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