Aging & Longevity
Rewriting destiny-gene-hacked stem cells ignite a revolution against aging
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Underappreciated role of canopy nitrogen deposition for forest productivity
Atmospheric nitrogen (N) deposition is generally expected to stimulate plant carbon (C) sequestration and promote tree growth, thereby mitigating atmospheric CO(2) accumulation. Yet, the magnitude of N deposition contribution to forest productivity remains contentious. While correlative studies suggest substantial plant growth enhancement, controlled fertilization experiments typically demonstrate a limited impact. This discrepancy may arise from whether or not to consider canopy N uptake...
Food as medicine: white and whole-grain bread consumption in relation to sarcopenia among older adults, insights from the Birjand Longitudinal Aging Study (BLAS)
This study aimed to examine the association between energy-adjusted consumption patterns of different types of bread, including whole-grain and white bread, and the risk of sarcopenia in older adults. In this cross-sectional study, sarcopenia was assessed using three tests: appendicular skeletal muscle mass (ASMM), handgrip strength, and gait speed, in 1,325 older adults from the Birjand Longitudinal Aging Study (BLAS), conducted between September 2018 and April 2019. Bread consumption was...
Healthy lifestyle, multimorbidity and all-cause mortality among older people: a retrospective cohort study based on CLHLS 2005-2018
CONCLUSIONS: Adherence to a healthy lifestyle is associated with a significantly lower risk of all-cause mortality in older people, especially among those with multimorbidity.
Rewired type I IFN signaling is linked to age-dependent differences in COVID-19
Advanced age is the most important risk factor for severe disease or death from COVID-19, but a thorough mechanistic understanding of the molecular and cellular underpinnings is lacking. Multi-omics analysis of 164 samples from SARS-CoV-2-infected persons aged 1 to 84 years reveals a rewiring of type I interferon (IFN) signaling with a gradual shift from signal transducer and activator of transcription 1 (STAT1) to STAT3 activation in monocytes, CD4^(+) T cells, and B cells with increasing age....
The role of mitophagy in perioperative neurocognitive disorder: from mechanisms to implications
Perioperative neurocognitive disorder (PND) is a significant neurological complication in aging perioperativepatients, seriously impacting their postoperative recovery and cognition as well as quality of life. The occurrence of PND is closely related to various factors, including neuroinflammation and oxidative stress, while the exact mechanism is still unknown. Mitophagy is a specialized form of autophagy and maintains cellular homeostasis by selectively degrading damaged and dysfunctional...
Progressive aerobic exercise in reducing inflammation and oxidative stress markers in older adult Korean women with obesity
CONCLUSIONS: A 16-week program of progressive aerobic exercise effectively reduced systemic inflammation and oxidative stress in older adult women with obesity, while potentially enhancing antioxidant defense. CCL11 reduction may reflect anti-inflammatory adaptations and potential neuroprotective benefits. These findings support aerobic exercise as a non-pharmacological strategy to manage age-related physiological decline.
Sirtuins mediate the reduction of age-related oxidative damage in the cochlea under a cocoa-rich diet
Age-related hearing loss (ARHL) is a common condition among older adults. It has long been established that ARHL is more prevalent, is more severe, and tends to occur earlier in men than in women. A key factor contributing to ARHL is oxidative stress, which harms the inner ear cells. Sirtuins are a family of proteins that play critical roles in cellular regulation, particularly in response to stress and aging, and have demonstrated anti-aging effects. Cocoa flavonoids, due to their antioxidant...
Modulating biological aging with food-derived signals: a systems and precision nutrition perspective
Lifespan extension has not prevented age-related decline. We propose that diet acts as a molecular modulator of aging, influencing inflammation, the microbiome, and systemic resilience. Biological age markers and AI-powered multi-omics reveal actionable dietary targets, including food-derived signals and Nutrition Dark Matter. We highlight precision nutrition and the EIT Food Healthy Aging Think & Do Tank as pathways to align science, policy, and practice for healthy aging.
Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength
Aging is associated with a progressive decline in tissue function and regenerative capacity, partly due to genomic instability, one of the hallmarks of aging^(1,2). Genomic instability encompasses DNA damage and the accumulation of somatic mutations in post-zygotic cells, yet the specific impact of these mutations on age-related tissue dysfunction remains poorly understood. To address this, we developed a mouse model in which genomic instability was induced specifically in muscle progenitor...
Sex-specific effects of aging and glycemic control on the association of possible sarcopenia in older adults with type 2 diabetes: a cross-sectional study
CONCLUSIONS: Glycemic control could be crucial in preventing possible sarcopenia, especially among older women with T2DM. Comorbid hypertension, IHD, or depression are significantly associated with sarcopenia in T2DM patients, particularly in the presence of poor glycemic control.
Remote monitoring in older adults with cancer, opportunities and challenges: a narrative review
CONCLUSION: Remote monitoring technologies hold promise for enhancing symptom and functional assessment in older adults with cancer, supporting age-appropriate care. However, robust geriatric-specific evidence is lacking. Future research should address technological challenges, validate clinical thresholds, and assess long-term outcomes. Integrating these tools within multidisciplinary frameworks can improve care delivery throughout the cancer journey.
Spatiotemporal profiling reveals the impact of caloric restriction in the aging mammalian brain
Caloric restriction (CR) is a well-studied intervention that extends lifespan and slows cognitive decline across species, yet the specific cell populations and molecular pathways involved remain elusive. In this study, we profiled >500,000 cells from 36 control and CR mouse brains across three age groups with EasySci single-nucleus transcriptomics and performed imaging-free IRISeq spatial transcriptomics on twelve brain sections from CR and control aged mice. We thereby explored the impact of CR...
My new home: study protocol for a prospective cohort study on the long-term personality development and short-term processes during transitions into nursing homes
BACKGROUND: Personality is a crucial predictor of many life outcomes, including successful ageing. The proportion of nursing home residents is increasing annually among older populations. Relocations to nursing homes affect multiple aspects of older people's lives, including their living environment, social interactions, and daily arrangements, which may indirectly affect their personality development. However, there is currently a lack of comprehensive assessments of how transitioning into a...
Predictive efficacy of waist-related indices for sarcopenic obesity incidence in Chinese older adults: a nationwide cohort study
This study aimed to evaluate the predictive capacity of the Body Roundness Index (BRI), Abdominal Body Shape Index (ABSI), Waist-to-Weight Index (WWI), and Waist-to-Height Ratio (WHtR) for sarcopenic obesity (SO) incidence among older adults in China using data from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). The cohort included 3,919 participants aged 65 and older, with a mean follow-up of 2.79 years. Sarcopenic obesity was defined by low muscle mass and high body fat....
Six-year transition patterns of activities of daily living in octogenarians: Tokyo oldest old in total health study
CONCLUSIONS: The results contribute to the understanding of aging-related functional trajectories and offer actionable insights for healthcare planning and intervention development.
Pathological aging is alleviated by neutralization of the autophagy-repressive tissue hormone DBI/ACBP
DBI/ACBP (diazepam binding inhibitor, acyl CoA-binding protein) is a macroautophagy/autophagy-inhibitory tissue hormone produced by multiple cell types. The plasma levels of DBI/ACBP rise with age and disease. In centenarians living in nursing homes, DBI/ACBP concentrations are approximately threefold higher than in younger adults (30-48 years old), but these levels increase further in centenarians hospitalized due to disease exacerbation. Elevated DBI/ACBP correlates with unfavorable clinical...
Sex differences in the association of cardiometabolic risk scores and blood pressure measurements with white matter hyperintensities in diverse older adults-HABS-HD
INTRODUCTION: We aimed to determine whether cardiometabolic risk factors and blood-pressure (BP) metrics were differentially associated with white matter hyperintensities volume (WMHV) in males versus females in the Health and Aging Brain Study-Health Disparities.
Possible and Probable Dementia and Depressive/Anxiety Symptoms in U.S. Older Adults: One-Year Follow-Up
Using data from the 2022 and 2023 U.S. National Aging and Health Trends Studies (N = 4,942 sample persons interviewed in both years), we examined cross-sectional and one-year lagged bidirectional relationships between the severity of cognitive impairment and depressive/anxiety symptoms. We fitted multinomial logistic and linear regression models for cross-sectional associations and a path model for one-year cross-lagged associations. Depressive/anxiety symptoms were cross-sectionally associated...
Effects of resistance-based training and polyphenol supplementation on physical function, metabolism, and inflammation in aging individuals
Aging is associated with declines in muscle mass, strength, aerobic capacity, and metabolic health, accompanied by increased low-grade inflammation. The purpose of this study was to assess the effects of 12 weeks of resistance training (RT) combined with minimal high-intensity interval training (HIIT), with or without polyphenol supplementation, on muscular, cardiovascular, metabolic, and inflammatory adaptations in healthy older adults. Forty-one men and women aged 55-70 years ingested either...
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