Aging & Longevity

Hypertension is a globally prevalent cardiovascular disorder with a multifactorial etiology involving genetic variations, environmental cues, aging and their complex interactions. Despite extensive research, the precise molecular mechanisms by which these factors drive hypertension remain incompletely elucidated. Traditional research has focused on classic pathological pathways, including renin-angiotensin-aldosterone system (RAAS) activation, endothelial dysfunction, oxidative stress, chronic...

Atherosclerosis (AS) is a chronic inflammatory vascular disease associated with aging, the initiation and progression of which is closely related to multiple cell death pathways. This review systematically elucidates the specific activation mechanisms and pathological contributions of ferroptosis, pyroptosis, apoptosis, autophagic cell death, necroptosis, NETosis, cuproptosis, parthanatos, and PANoptosis in vascular endothelial cells (VECs), macrophages, vascular smooth muscle cells (VSMCs), and...

Obesity impairs subcutaneous adipose tissue function, which predisposes to chronic cardiometabolic comorbidities and accelerated biological aging. However, regulatory variants, their target genes and epigenomic landscape underlying this predisposition in each subcutaneous adipose tissue cell-type remain elusive. Our subcutaneous adipose tissue cell-type level cis-expression quantitative trait and colocalization analyses reveal cis-expression quantitative trait locus variants, regulating 279...

Biological ageing is often approached through its underlying mechanisms and their therapeutic potential. Yet age-related decline arises from multiple processes shaped by evolutionary constraints and finite investment in somatic maintenance. Coupling among these processes is heterogeneous: some are tightly linked through shared signalling networks, others are indirectly related and some retain substantial autonomy. Interventions that modulate biomarkers of biological age or individual hallmarks...

Lycium barbarum (goji berry) has long been consumed as a food, and its water-soluble polysaccharides (LBPs) are proposed as key bioactive constituents. Here, we evaluated three L. barbarum fractions in Caenorhabditis elegans and subsequently focused on purified LBPs, which showed the most consistent pro-longevity phenotype in preliminary screening. LBPs (700 μg/mL) increased mean lifespan by 20.67% (p < 0.01) and improved multiple healthspan-related outcomes, including locomotion, resistance to...

The Davos Alzheimer's Collaborative (DAC) Egypt Cohort (DAC-Egypt) is a newly established longitudinal study of cognitive aging in a community-based convenience sample of older Egyptian adults. The cohort's purpose is to characterize trajectories of cognitive decline and dementia risk factors in an understudied population, filling a critical gap in aging research in the Middle East. Participants (n = 1,530) aged 55 and above were recruited via regionally diverse convenience sampling, with...

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Skeletal muscle is a fundamental tissue as it is found throughout the body, sustains posture, and produces movement. Yet, skeletal muscle disorders, such as myopathies, affect a large percentage of the population, degrading an individual's quality of life. A recent study links myopathy progression to the decline in chaperone-mediated autophagy that occurs during aging. Underscoring the importance of a balanced CMA pathway in maintaining skeletal muscle function and integrity, the study also...

In an ever-changing environment, the ability to adapt behavior based on feedback is a crucial skill. Although this process is assumed to decline with age, initial evidence suggests that emotional information processing may help buffer against these age-related impairments. We therefore conducted a probabilistic learning task with emotional faces in two varying emotional intensities (weak vs. strong) to investigate whether healthy younger and older adults would benefit from strong emotional...

Autism spectrum disorder (ASD) is a neurodevelopmental disorder. While previous studies have reported a high prevalence of dementia diagnoses in the ASD population, the risk of dementia-related neurodegeneration remains poorly understood. This study aimed to assess dementia-sensitive composite measures of brain structure and brain age across the lifespan in an ASD cohort (ages 7-73) to investigate neuroanatomical features linked to neurodegenerative vulnerability. The composite score and brain...

CONCLUSION: We propose a comprehensive framework comprising three components: cohort setting, measuring contributing factors, and full assessment. This framework sets the stage for a unified, supranational protocol that harmonizes survey methods across countries, integrates multidisciplinary perspectives, and adopts a longitudinal approach. It would enable larger sample sizes and more robust statistical analyses, allowing researchers to explore complex relationships and derive more accurate...

The aim of this study is to investigate perceptions of aging among Hispanic adults. Fifty participants in Texas and Arkansas were asked to take a short questionnaire including multiple-choice and Likert scale format questions. Individuals 18 and older who identified as Hispanic were included in the study. Counts and frequencies for each response were obtained. Furthermore, an exploratory comparison of responses between younger and middle-aged/older respondents was conducted. According to the...

Aging is associated with a decline in the regenerative capacity of many tissues. Central to this decline is a complex interplay between inflammation and stem cell function. How these two processes are linked and influence regenerative capacity remains unclear. Here, we undertake a comprehensive assessment of age-related changes in the mouse colon at single-cell resolution. A survey of immune and epithelial compartments revealed a hyperactivated inflammatory state in the colon of old mice...

DNA-protein crosslinks (DPCs) are toxic DNA lesions that block all DNA transactions including replication and transcription, and the consequences of impaired DNA-protein crosslink repair (DPCR) are severe. At the cellular level, impaired DPCR leads to the formation of double strand breaks, genomic instability, and cell death, while at the organismal level, it is associated with cancer, aging, and neurodegeneration. Despite its importance, the mechanisms of DPCR at the organismal level are...

Chronic systemic inflammation and DNA methylation changes are two major hallmarks of aging, yet their interaction is poorly known. We investigated the relation between circulating inflammatory proteome and epigenetic age acceleration as assessed by DNA methylation in four independent cohorts of different ages and health conditions. Epigenetic age scores known to predict human health span (GrimAge and PhenoAge) were more strongly associated with age-associated inflammatory proteins, frailty, and...

Inundations of pelagic Sargassum plague the tropical Atlantic, with size and impacts steadily increasing to surpass 30 million tons in 2025. Understanding the drivers of Sargassum growth in the so-called Great Atlantic Sargassum Belt is fundamental to developing effective mitigation strategies for affected nations. We present a nonlinear regression model that both explains the seasonal and interannual variability observed between 2011 and 2022 and predicts Sargassum concentrations in 2023 and...

Adipose tissues are highly dynamic in response to environmental temperature changes. During aging, subcutaneous white adipose tissues (WAT) decreases, yet whether this atrophy exacerbates cold stress and triggers systemic aging remains unclear. Here we show that adipocyte-specific expression of the Lmna^(G609G) mutation in male mice leads to progressive WAT atrophy, accelerates aging, and shortens lifespan, whereas female mice remain unaffected. This lipoatrophy exacerbates cold stress,...

CONCLUSIONS: The NCDs exacerbate healthcare inequities with socio-economically vulnerable older adult households at greater risk of CHE, impoverishment and worsened economic condition. Public funded health insurance programmes offered limited protection compared to private schemes.

CONCLUSION: Engaging in physical activity among the elderly South Asian population is affected by a complex mixture of individual, social, and cultural factors. For South Asians, it is important that interventions be implemented in a manner that meets the needs regarding capabilitymotivation, and support.

Spatial disorientation represents a clinically meaningful vulnerability during aging and is an early manifestation along the Alzheimer's disease continuum. Understanding how aging-related central nervous system (CNS) changes affect the neural computations required for spatial perspective taking (SPT) is essential for characterizing early neurodegenerative processes. In this study, older adults with mild cognitive impairment (MCI) and subjective cognitive decline (SCD) completed a simplified...