Aging & Longevity

Topoisomerase III-beta (Top3b) reduces nucleic acid torsional stress and intertwining generated during RNA and DNA metabolism while protecting the genome from pathological R-loops, which otherwise result in DNA breakage and genome instability. By studying Top3b knockout mice (Top3b-KO), we find that the loss of Top3b accelerates the development of spontaneous atypical lymphoid hyperplasia and lymphomas arising in spleens and lymph nodes, organs with prominent Top3b expression. Aging Top3b-KO...

CONCLUSION: This study developed and internally validated a dynamic, nomogram-based scoring tool for early detection of MCI that integrates non-invasive retinal and visual biomarkers. The model demonstrated high discriminative power and substantial clinical net benefit. Further evaluation of the model's prognostic value in predicting further cognitive decline may support its clinical utility.

CONCLUSION: Postmenopausal women showed distinct epigenetic patterns in response to exercise, although these differences must be interpreted cautiously given the small premenopausal sample size. These results suggest potential immune cell-associated DNA methylation markers to inform personalized exercise strategies supporting healthy aging in women.

For memories to remain relevant and adaptive over the lifespan, modifications under specific conditions are required. Memory reconsolidation theory suggests that when a memory is reactivated, it can become labile, a state known as destabilization. This process is regulated by complex and dynamic neurobiological changes representing biological boundary conditions, which likely protect important memories from undergoing unnecessary or potentially maladaptive modifications. External cues, such as...

Diapause is an evolutionarily conserved strategy that enables many organisms to survive prolonged exposure to harsh environmental stressors. During this state, organisms drastically reduce their metabolic rate, halt development, and enhance stress tolerance in an energy-efficient manner. Remarkably, many diapausing organisms appear to substantially slow or suspend aging as a result of profound metabolic depression and developmental arrest. Consequently, diapause and aging appear to be programmed...

Sepsis-induced cardiac dysfunction is a major contributor to sepsis-related mortality, and many patients continue to experience long-term cardiac complications after recovery. Here, we demonstrate that cardiac senescence is a key feature of sepsis-associated cardiac dysfunction, with endothelial cells identified as the predominant senescent population in septic cardiac tissue. However, the pathogenic drivers of endothelial senescence in sepsis remain poorly characterized. Among potential...

Adult stem cells (SCs) transition between quiescent and active states to maintain tissue integrity, and dysregulation of this balance can lead to tissue degeneration, cancer, or premature aging. Both intrinsic factors and extrinsic niche signals influence these states; however, the molecular mechanisms that integrate extrinsic cues with intrinsic programs remain poorly understood. Here, we show that the conserved repressive histone mark, H2AK119ub, serves as a molecular switch linking inhibitory...

Biological clocks aim to estimate the physiological state of an organism, or of specific organs or systems, from the perspective of aging. The inferred individual age acceleration is presumably linked to increased mortality and morbidity risks. Here, we introduce a cognitive aging clock based on a battery of five tests (sensomotor arithmetic, sensomotor mirror letter, 1-back, campimetry and the Stroop), capturing sensory and verbal perception, working memory, and decision-making in the context...

Tree longevity is thought to increase in growth-limiting, adverse environments, but a quantitative assessment of drivers of global variation in tree longevity is lacking. We assemble a global database of maximum longevity for 739 tree species and analyse associations between longevity and climate, soil, and species' functional traits. Our results show two primary pathways towards long lifespans. The first is slow growth in resource-limited environments, consistent with the "adversity begets...

CONCLUSIONS: The Chinese version of BioPMovQ has good reliability and validity, and can be used to measure the relationship between pain and various factors related to exercise behavior in elderly patients with CMP from a biological behavioral perspective.

CONCLUSION: Among geriatric patients, a FRD appears to prevail, extending beyond a neutral acceptance of death's inevitability and existing independently of suicidality, depression, frailty, or disease burden. Understanding a FRD may help contextualize older individuals' acceptance of aging and could impact geriatric treatment outcomes.

CONCLUSION: This study highlights distinct EoL healthcare and social services utilization and related costs among older adults, depending on the cause of death, age, and sex. These findings underscore the need for tailored care strategies that reflect different EoL trajectories.

CONCLUSION: Our findings suggest that regular AGPA is associated with markers of slower neurovascular aging in older individuals. AGPA induces a combination of general physical activity-related and specific AGPA-related effects; moreover, it may offer similar or even greater benefits than physical activity alone. Therefore, habitual AGPA may serve as an effective preventive strategy for neurovascular aging.

CONCLUSION: In healthy older adults, a single session of tDCS designed to modulate DAN and DN excitability concurrently improved gait speed in both single and dual-task walking, as well as working memory. These preliminary findings suggest that gait and working memory may be modifiable through neuromodulation approaches involving DAN and DN. Further studies are warranted to explore the relationship between gait, working memory, and these two brain networks using neuroimaging means.

Aging is a natural physiological process that may be accompanied by pathological changes, particularly in the brain. Iron is an essential trace element supporting various physiological functions and maintaining cellular homeostasis. However, iron levels tend to increase in certain brain regions of older adults and are associated with the development of neurodegenerative diseases. Despite this association, the causal relationship between aging, iron accumulation, and neurodegenerative diseases...

Women's reproductive health plays a pivotal role in both longevity and the aging process. We conduct Mendelian randomization (MR) and observational analyses to investigate these relationships. Univariate MR analyses reveal that older age at first birth, later menarche, higher estradiol, and sex hormone-binding globulin (SHBG) increase longevity, while pre-eclampsia liability decreases longevity. Older ages at first birth and at first sexual intercourse are associated with lower DNAmGrimAgeAccel,...

Despite ample research on cognitive aging, it is still largely unknown whether cognition is organized in a distinct manner, with different cognitive domains and subcomponents interrelating with each other. It is also unknown whether this cognitive organization is stable or changes with increasing age. Following the PRISMA guidelines statement, we conducted a systematic review of multivariate studies of cognitive aging with the aim to identify a potential cognitive organization in healthy aging....

Senescence contributes to the pathology of abdominal aortic aneurysm (AAA); however, the regulation of senescence in AAA remains unclear. Here, we sought to determine the role of gasdermin-E (GSDME)-dependent non-canonical pyroptosis in AAA. GSDME-dependent non-canonical pyroptosis is activated in the lesioned vascular walls of mouse models and patients with AAA. GSDME deficiency inhibits vascular senescence and AAA progression. Combined analyses of single-cell RNA sequencing (scRNA-seq), bulk...

Hepatocellular carcinoma (HCC) is one of the most prevalent and malignant forms of primary liver cancer, with limited therapeutic options and a poor prognosis. Cellular senescence contributes to the progression of chronic liver disease while creating a microenvironment that supports tumor growth. This study aims to identify dual-purpose therapeutic targets for HCC treatment and cellular senescence intervention, potentially leading to more effective therapeutic strategies. Utilizing the AI-driven...

Accelerated biological aging (BA) is linked to adverse cardiovascular events, but its role in heart failure with preserved ejection fraction (HFpEF) remains unclear. We analyzed 1,727 HFpEF patients from RED-CARPET Study (ChiCTR2000039901), assessing BA using Klemera-Doubal and PhenoAge methods. During a median 4.9-year follow-up, 321 all-cause and 180 cardiovascular deaths occurred. After full adjustment, per 1-SD increase in BA acceleration showed significantly higher risk of all-cause...