Aging & Longevity
Analysis of health information needs of elderly patients with chronic diseases based on Kano Model: a descriptive cross-sectional study
CONCLUSIONS: This study combines the Kano Model with the self-designed needs questionnaire to systematically classify and rank the health information needs of older patients with chronic diseases by priority. The results provide a novel analytical framework for related research. By clarifying the satisfaction paths of different types of needs, the study can serve as a valuable guide for optimising service supply and promoting the efficient allocation of health information resources. In...
Association between community-based health services and health lifestyles of older adults: evidence from China
CONCLUSION: This study confirmed the role of public health services in shaping the health lifestyles of older adults, so as to promote healthy aging. The study also has limitations in the comprehensive assessment of health lifestyles, causal inference, and the acquisition of recent data.
Transforming aged care in China: insights from a TF-IDF-based data mining analysis of national policies (2018-2022)
CONCLUSIONS: This research provides critical insights for global policymakers facing similar demographic challenges, advocating for a resilient, holistic, and inclusive aged care system.
Development and validation of a predictive model for sarcopenia risk in older Chinese adults based on key factors
CONCLUSIONS: This study offers a practical and interpretable predictive model for sarcopenia, highlighting key modifiable risk factors such as BMI and sleep duration. The findings underscore the critical need for evidence-based, individualized prevention strategies and a multidisciplinary approach to mitigate sarcopenia in aging populations.
Impact of wearable-assisted walking on sarcopenia and body composition in older adults
CONCLUSIONS: Wearable devices, such as smartwatches and fitness trackers, provide real-time feedback and enable tailored exercise recommendations, offering a practical and personalized strategy for mitigating sarcopenia. This study confirms that wearable-assisted walking programs effectively improve muscle health and functional performance in older adults, reinforcing their potential for promoting healthy aging.
Evaluating swallowing capacity in older adults with dysphagia: high protein, low carbohydrate smoothie formulas versus commercial formula
CONCLUSIONS: The findings suggest that smoothie drinks, particularly WS (51-350 centipoise), may offer a viable alternative to commercial formula (1-50 centipoise) for older adults with dysphagia, potentially reducing premature spillage. The findings provide useful preliminary insights into the potential of these formulas to support safer swallowing. Further research, including longer-term studies, would help to more fully explore their nutritional benefits, safety, and applicability across...
Loneliness and its associated factors in older Australians residing in retirement living communities: a cross-sectional study
CONCLUSIONS: Findings suggest that both psychological and physical factors are associated with experiencing loneliness, in addition to increased susceptibility upon village entry. Identification of these factors permits co-design and implementation of targeted initiatives to support residents' social wellbeing.
Status and factors associated with health service utilization among older adults in China: a recent national population-based survey
CONCLUSION: The overall level of health service utilization among older adults is low, so policies and decision-makers can consider improving the development of targeted measures for different service types to increase the utilization rate of medical care services for the elderly and promote the health equity of vulnerable groups.
Impact of socioeconomic status on obesity in older adults: the suppressive effect of social support and sleep quality
CONCLUSIONS: Greater social support and sleep quality lower the obesity risk associated with SES in older adults. Therefore, targeted prevention, control, and intervention measures, such as increasing social support and improving sleep quality, can be applied based on the characteristics of older adults of different socioeconomic statuses to minimize the socioeconomic status-associated obesity risks and thus achieve the goal of reducing obesity.
Predictors of transition from independence to limitations in activities of daily living (ADL) among independent community-dwelling older adults: longitudinal evidence from the Malaysia ageing and retirement survey (MARS)
CONCLUSIONS: The prevalence of ADL limitation among community-dwelling older adults in Malaysia was comparable to the other reported figures. Lower levels of physical activity and abnormal BMI were two modifiable predictors of transition to ADL limitation among independent older adults. As such, policy strategies to further enhance active lifestyles and maintain normal BMI levels, especially among independent older adults, should be explored.
Global burden of disease and its risk factors for adults aged 70 and older across 204 countries and territories: a comprehensive analysis of the Global Burden of Disease Study 2021
CONCLUSIONS: The global disease burden among adults aged 70 and older has shown declines in death and DALY rates, yet remains a significant challenge exacerbated by population growth, especially in less developed regions. Implementing preventive strategies that target primary risk factors early and enhancing treatment of underlying conditions are crucial.
A secondary analysis of cortical atrophy and plasma amyloid β patterns in older patients with cognitive frailty undergoing elective surgery
CONCLUSION: Our results suggest that atrophy in aging- and AD-related cortical regions is associated with cognitive frailty. Plasma amyloid β42/β40-ratios were significantly lower in patients with frailty and cognitive frailty, suggesting that (pre-)frailty in general, rather than cognitive frailty specifically, is associated with AD-like changes. Hence, AD-related pathology seems to be associated with cognitive frailty, but the available data is not sufficient to indicate shared pathomechanisms...
Validating Community for Successful Ageing (ComSA) BioPsychoSocial Risk Screener Version II (BPS-RS II) with Diverse Multi-Ethnic Senior Populations in Singapore: A Mixed-Methods Study
CONCLUSIONS: Using BPS-RS II over I is recommended for biopsychosocial risk assessment and stratifying older people to interventions for population health management. The updated tool is theory-based, culturally sensitive to multi-ethnic contexts in Singapore, and shows improved associations with health-related outcomes, and strong associations with QoL.
Exploring the public's perception and understanding of Parkinson's disease in Ireland: a study protocol
BACKGROUND: There appears to be a lack of empirical investigation on how the public currently understands Parkinson's Disease (PD)and the impact this has on people with PD and their carers, across Ireland. This research hopes to build a greater public understanding of PD, reduce stigma and improve the quality of life for people with PD. The aim of this study is to (1) explore public perceptions, awareness and understanding about PD across the island of Ireland and (2) discover how this impacts...
Pancreatic surgery is safe in elderly patients with PDAC
CONCLUSION: With comprehensive preoperative evaluation and careful postoperative care, pancreatic surgery is safe for elderly patients in experienced pancreatic cancer centers.
Attitudes to aging, depression, and death anxiety among community-dwelling older adults: a cross-sectional correlational study
CONCLUSION: This result highlights that interventions should be planned in order to reduce death anxiety among community-dwelling older adults by taking the attitude to ageing and the symptoms of depression into account.
Personalised, GIS-based counselling to promote habitual walking in mobility-limited and chronically ill older adults: protocol of the MOBITEC-Routes randomised controlled trial
BACKGROUND: Physical activity is a cornerstone of health for older adults. Recent evidence underscores that even regular light activity, such as routine walking, offers substantial health benefits. Traditional approaches to promoting walking often overlook the importance of the local neighbourhood environment and the wide range of abilities and preferences of older adults. A personalised walking intervention - emphasizing personal preferences and local facilitators by employing Geographic...
Frail older people ageing in place alone and their perception of the built environment in rural and urban sites: a mixed-methods study
CONCLUSIONS: Despite the small/not representative sample size, the results highlight how, a built environment that is perceived as inadequate, could hamper ageing in place and participating in communities for frail seniors. This could be managed with appropriate interventions to be implemented taking into account the diversity between rural and urban sites.
Cardiolipin-mimic lipid nanoparticles without antibody modification delivered senolytic in vivo CAR-T therapy for inflamm-aging
mRNA-based in vivo chimeric antigen receptor (CAR)-T cell engineering offers advantages over ex vivo therapies, including streamlined manufacturing and transient expression. However, current delivery methods require antibody-modified vehicles with manufacturing challenges. In this study, inspired by cardiolipin, we identify cardiolipin-like di-phosphoramide lipids that improve T cell transfection without targeting ligands, both in vitro and in vivo. The T cell-favored tropism is likely due to...
Immuno-metabolic stress responses control longevity from mitochondrial translation inhibition in C. elegans
Perturbing mitochondrial translation represents a conserved longevity intervention, with proteostasis processes proposed to mediate the resulting lifespan extension. Here, we explore whether other mechanisms may contribute to lifespan extension upon mitochondrial translation inhibition. Using multi-omics and functional in vivo screening, we identify the ethylmalonyl-CoA decarboxylase orthologue C32E8.9 in C. elegans as an essential factor for longevity induced by mitochondrial translation...
Aging and Longevity: Latest results from PubMed
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