Aging & Longevity

Development of planning of the integrated care for older people in China: a theory of change approach

1 week 2 days ago
CONCLUSION: The ToC is effective in identifying key characteristics of resources, interventions, impact, and outcomes of integrated care for OP. Our ICOPE program has been strengthened by ToC, which forms an integrated care model for assessment, planning, implementation, and evaluation, adapted to a specific setting, and provides guidance for other areas in similar settings.
Biyan Jiang

Regionally specific picture naming benefits of focal tDCS are dependent on baseline performance in older adults

1 week 2 days ago
Word-finding difficulty is a common challenge in older age and is linked to various neuropathological conditions associated with ageing. Transcranial direct current stimulation (tDCS) has shown promise as a cognitive enhancement tool for both healthy aging and age- related cognitive disorders. However, its effectiveness in enhancing word-finding ability remains inconsistent, especially among healthy adults. Variability across studies is likely due to factors such as task selection, stimulation...
A Yucel

Emergence of CpG-cluster blanket methylation in aged tissues: a novel signature of epigenomic aging

1 week 2 days ago
Aging is accompanied by widespread DNA methylation changes across the genome. While age-related methylation studies typically focus on individual CpGs, cluster analysis provides more robust data and improved interpretation. We characterized age-associated CpG-cluster methylation changes in mouse spleens, peripheral blood mononuclear cells, and livers. We identified a novel signature termed blanket methylations (BMs), fully methylated CpG clusters absent in young tissues but appearing in aged...
Yong-Kook Kang

The associations between biological markers of aging and appetite loss across adulthood: retrospective case-control data from the INSPIRE-T study

1 week 2 days ago
Appetite loss is a common clinical condition in older adulthood, but how this condition associates with biological aging remains unknown. The present study aims to examine the associations of biological aging markers with appetite loss in community-dwelling people aged 21 to 102 years. This retrospective case-control study used baseline data from the INSPIRE-T cohort in Toulouse, France. Each of the 49 cases with appetite loss was sex- and age-matched to two controls without appetite loss (n =...
Annelie Turesson

Spontaneous intracerebral hemorrhage during computed tomography scanning-assessment of hyperacute hematoma growth

1 week 3 days ago
Pathophysiological mechanisms underlying hematoma expansion in spontaneous intracerebral hemorrhage (ICH) remain poorly understood, and most data are derived from postmortem studies or serial neuroimaging studies performed over hours to days from onset. Our unique case report of a hypertensive ICH serendipitously captured by serial CT provides valuable in vivo data from the very onset of hematoma formation in an aging individual. A 76-year-old hypertensive man underwent elective carotid CT...
Bence Gunda

Characterizing complex care relationships in Canada using the Canadian Longitudinal Study on Aging (CLSA)

1 week 3 days ago
CONCLUSION: We found that a large proportion of caregiving relationships were best described as a network that frequently included multiple caregivers, multiple care receivers, and some in both roles, as well as non-kin and extended relative participants. This characterization of care relationships allows us to better understand the needs of older adults and their caregivers as the population ages and care shifts towards aging-in-place strategies.
Janaia Utas

Age-specific neural responses to SMA and M1 stimulation during implicit motor sequence learning: Insights from a concurrent tDCS-fNIRS approach

1 week 3 days ago
Implicit Motor Sequence Learning (IMSL) is critical for automating motor skills, yet it declines with age, impacting independence and quality of life. This study investigated the age-specific roles of the primary motor cortex (M1) and supplementary motor area (SMA) in IMSL using a novel concurrent transcranial direct current stimulation (tDCS) and functional near-infrared spectroscopy (fNIRS) approach. Twenty younger adults (21-32 years old [M = 24.3 ± 3.26]) and twenty older adults (60-76 years...
Jessie Siew-Pin Leuk

Foldable anode-free sodium batteries enabled by N,P-codoped carbon macroporous fibers incorporated with CoP nanoparticles

1 week 3 days ago
Anode-free sodium batteries (AFNBs) are regarded as promising alternatives for next-generation energy storage systems because of their high energy density, high safety, cost-effectiveness, and simple manufacturing processes. However, their practical application is limited by a low coulombic efficiency (CE) and a short lifespan resulting from a large volume change and the growth of Na dendrites. Here, we propose a three-dimensional versatile host composed of interconnected N,P-codoped carbon...
Yongling An

SQSTM1/p62 Orchestrates Skin Aging via USP7 Degradation

1 week 3 days ago
Skin aging is a complex process driven by intrinsic genetic factors and extrinsic environmental influences. In this study, sequestosome1 (SQSTM1/p62) was identified as a key regulator of senescence, the senescence-associated secretory phenotype (SASP), and skin aging. Notably, p62 expression is reduced in senescent cells and aging skin of both humans and mice. The depletion of p62 in the epidermis was found to be positively associated with accelerated aging and the initiation of SASP....
Liu Chen

Social networks of neighbourhood inhabitants, residents of a care facility, and nursing staff: a case study in two long-term care facilities in the Netherlands

1 week 3 days ago
CONCLUSIONS: Although it may be difficult for residents with dementia to maintain their social networks as part of their illness, there are numerous ties that attest to the social roles of persons with dementia in the community. These ties can be used to provide person-centred care, but are also an important resource in finding and retaining personnel and volunteers.
Adriana P A van Beek

Replacement as an aging intervention

1 week 3 days ago
Substantial progress in aging research continues to deepen our understanding of the fundamental mechanisms of aging, yet there is a lack of interventions conclusively shown to attenuate the processes of aging in humans. By contrast, replacement interventions such as joint replacements, pacemaker devices and transplant therapies have a long history of restoring function in injury or disease contexts. Here, we consider biological and synthetic replacement-based strategies as aging interventions....
Sierra Lore

A Proposed Universal "Home Time" Quality of Life Measure for Older Adults

1 week 3 days ago
CONCLUSION: A "1.0" universal person-centered home time measure that reflects QoL should include days in the emergency department, inpatient care, and post-acute care. Expert input revealed domains of agreement and disagreement. Future validation efforts that incorporate expert input are needed to iterate and arrive at the optimal measure.
Courtney H Van Houtven

Targeted disruption of PRC1.1 complex enhances bone remodeling

1 week 3 days ago
Polycomb repressive complexes (PRCs) are pivotal epigenetic regulators that preserve cell identity by restricting transcription responses to sub-threshold extracellular signals. Their roles in osteoblast function and bone formation remain unclear. Here in aging osteoblasts, we found marked activation of PRC1.1 complex, with KDM2B acting as a chromatin-binding factor and BCOR and PCGF1 enabling histone H2A monoubiquitylation (H2AK119ub1). Osteoblast-specific Kdm2b inactivation significantly...
Liangyu Xing

A membrane-free electrochemical reactor for efficient oxygen removal via gravity-assisted product self-separation

1 week 3 days ago
Although electrochemical technologies offer vast industrial prospects, broader adoption-particularly in consumer applications-remains constrained by high costs and limited component lifespans. Here, we present a gravity-assisted, membrane-free electrochemical oxygen (O(2)) removal (EOR) reactor coupling oxygen reduction (ORR) and oxygen evolution (OER) reactions. Leveraging fluid mechanics insights, buoyant O(2) bubbles ascend rapidly, achieving 95% product self-separation and eliminating the...
Peng Li

Age-associated methionine sulfoxide reductase A protects against valvular interstitial cell senescence and valvular calcification

1 week 3 days ago
Calcific aortic valve disease (CAVD) is a cardiovascular disease prevalent in the aging population, resulting in high morbidity and mortality rates. However, the molecular mechanisms underlying CAVD remain unclear. We initially conducted an RNA sequencing analysis of aortic valve leaflets from rats of different ages to identify key genes involved in valvular aging and calcification. Bioinformatics analysis demonstrated that methionine sulfoxide reductase A (MSRA) was crucial to valvular...
Qing Li

NF-kappaB-mediated developmental delay extends lifespan in Drosophila

1 week 4 days ago
Developmental time (or time to maturity) strongly correlates with an animal's maximum lifespan, with late-maturing individuals often living longer. However, the genetic mechanisms underlying this phenomenon remain largely unknown. This may be because most previously identified longevity genes regulate growth rate rather than developmental time. To address this gap, we genetically manipulated prothoracicotropic hormone (PTTH), the primary regulator of developmental timing in Drosophila, to...
Ping Kang
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