Aging & Longevity

Gene expression and co-expression heterogeneity patterns and biodemography analyses during the cell cycle encourage aging studies in archaea

5 days 23 hours ago
One of the prokaryotic partners at the origin of eukaryotes was an archaeon, but do archaea age, and if so, how? Uncovering aging in Archaea might provide more general clues about cellular senescence and rejuvenation and their origins. To fill this knowledge gap, we focused on Saccharolobus islandicus, a model archaeon for which the cell cycle can be synchronized and controlled. We generated longitudinal transcriptomes of synchronized S. islandicus populations that capture typical expression and...
Yuping Dai

Effects of positive sex education and pelvic floor strengthening program on sexual and pelvic health among youngest old: a randomized controlled trial

6 days 23 hours ago
CONCLUSIONS: The sexual program which handled comprehensive and interdisciplinary approach could offer more than just addressing sexual function. Due to the unreached significant increase in sexual esteem and sexual quality of life and lack of knowledge about these, there is a need to have future studies. It is essential for national health policies to incorporate and act on interdisciplinary approach to sexuality in older adults.
Ayse Deliktas Demirci

Determinants of waiting times for surgery in older patients with hip fractures: a two-center retrospective study in Japanese acute care hospitals

6 days 23 hours ago
CONCLUSIONS: Both patient- and healthcare system–related factors were associated with delayed surgery for hip fractures in older adults. Although a reimbursement incentive has been introduced to promote early surgery, real-world challenges, including preoperative risk factors and hospital resources, continue to affect surgical timing. These findings could help inform strategies to enhance timely surgical care for older patients with hip fractures in aging societies.
Yunhan Ji

Health-related needs and indicators of an age-friendly city: a survey from the perspective of older adults in a province in Southeastern Iran

6 days 23 hours ago
CONCLUSION: This study offers valuable insights into the health-related needs and indicators of an age-friendly city for older adults in a province in Iran. The results can guide managers, policymakers, and planners in developing effective strategies for elderly care at both national and regional levels.
Jamileh Farokhzadian

Neurobiological effects of exergame interventions in older adults with or without a neurocognitive disorder: A systematic review

6 days 23 hours ago
Exergames (EG) are interactive video games that require physical activity and use gamification to make exercise more engaging. EG interventions demonstrated various benefits for older adults including improved mental health, quality of life, and a reduced risk of falls. Enhanced cognition is considered one of the principal targets driving these benefits. This systematic review aimed to identify the neurobiological effects of EG interventions in healthy older adults and those with neurocognitive...
Elpidio Attoh-Mensah

Osteoimmunology and aging: Mechanisms, implications, and therapeutic perspectives

6 days 23 hours ago
Osteoimmunology is an interdisciplinary study of the interaction between the immune system and the skeletal system, aiming to reveal the immune regulation mechanisms that affect bone health and disease. Aging is a macro concept, which is not limited to the senescence of cells, but also includes the aging of the body as a whole. Studies have shown that aging can affect osteoimmune function through various mechanisms such as affecting the bone marrow microenvironment, causing immune cell...
Yu-Tong Wang

Mechanisms underlying the interplay between autophagy and the inflammasome in age-related diseases: Implications for exercise immunology

6 days 23 hours ago
Aging is a multifactorial process characterized by cellular dysfunction and increased susceptibility to age-related diseases. The interplay between autophagy and inflammasome has emerged as a critical factor influencing the aging process. Autophagy, which is responsible for degrading damaged cellular components, declines with age, leading to the accumulation of dysfunctional organelles and misfolded proteins. At the same time, the inflammasome, a key mediator of inflammatory responses, becomes...
Eliézer Lucas Pires Ramos

DDX1 methylation mediated MATR3 splicing regulates intervertebral disc degeneration by initiating chromatin reprogramming

6 days 23 hours ago
Low back pain (LBP), primarily driven by intervertebral disc degeneration (IVDD), has become a core challenge in public health. DDX1, an RNA-binding protein, plays key roles in RNA metabolism but its function in IVDD remains unclear. We identify DDX1 as a substrate of methyltransferase EZH2, which methylates DDX1 at lysine 234 (K234), promoting IVDD in vitro and in vivo. EZH2 inhibition restores matrix homeostasis in nucleus pulposus (NP) cells and slows IVDD progression. Methylation at DDX1...
Dingchao Zhu

Molecular and functional diversity of the autonomic nervous system

6 days 23 hours ago
The autonomic nervous system (ANS) plays a pivotal role in regulating organ functions through descending brain-to-body signalling. The pathways involved are broadly categorized into two major branches: the sympathetic nervous system, which mediates 'fight or flight' responses, and the parasympathetic nervous system, which governs 'rest and digest' functions. Historically, the ANS was considered to mediate simple motor functions with limited neurochemical diversity. However, recent advances in...
Tongtong Wang

Clean energy use among elderly people and its influencing factors under community health construction background in China

6 days 23 hours ago
CONCLUSION: The results indicate that clean energy use among older adults in China is regionally unbalanced and affected by various internal and external factors. Strategies to improve clean energy utilization among elderly adults in China should focus on rural areas with low socioeconomic levels and poorer health and living conditions.
Zijun Zhao

The transcription factor Bcl11a is essential for B-1a cell maintenance during aging

6 days 23 hours ago
B-1a cells, a self-renewing B cell subset essential for innate immunity, produce natural IgM antibodies that defend against pathogens, yet mechanisms sustaining their maintenance during aging remain unclear. We report that aging B-1a cells exhibit hallmarks of decline, including DNA damage, apoptosis, and reduced proliferation, with striking sex-specific disparities: aged females retain higher B-1a cell numbers than males, correlating with enhanced glycolysis and chromatin accessibility. Motif...
Shasha Xu

BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure

6 days 23 hours ago
Aging is a prominent risk factor for heart disease, driving pathological cardiac changes such as hypertrophy, fibrosis, and cellular senescence. While BubR1 has been linked to systemic aging in mammalian models, its specific role in regulating cardiac aging remains unclear. Here, we investigated how BubR1 regulates heart aging and its potential contribution to the pathogenesis of cardiac disease, including heart failure. BubR1 insufficiency in mice resulted in marked cardiac hypertrophy,...
Renju Pun

Centenarians and near-centenarians in India: empirical insights on health and well-being characteristics

6 days 23 hours ago
We examined the socioeconomic and health characteristics of centenarians (100 years or above) and near-centenarians (90-99 years) in India. Utilizing data from the Wave-1 of the Longitudinal Ageing Study of India (LASI), we compared the distribution of centenarians and near-centenarians with those aged 60-89 years across socioeconomic, health, and subjective well-being indicators. Our findings revealed that most of the sample centenarians and near-centenarians were female, educated, and widowed....
Sunil Rajpal

The Somatic Mosaicism across Human Tissues Network

6 days 23 hours ago
From fertilization onwards, the cells of the human body acquire variations in their DNA sequence, known as somatic mutations. These postzygotic mutations arise from intrinsic errors in DNA replication and repair, as well as from exposure to mutagens. Somatic mutations have been implicated in some diseases, but a fundamental understanding of the frequency, type and patterns of mutations across healthy human tissues has been limited. This is primarily due to the small proportion of cells...
Tim H H Coorens

WSTF nuclear autophagy regulates chronic but not acute inflammation

6 days 23 hours ago
Acute inflammation is an essential response that our bodies use to combat infections¹. However, in the absence of infections, chronic inflammation can have a pivotal role in the onset and progression of chronic diseases, such as arthritis, cancer, autoimmune disorders, metabolic-dysfunction-associated steatohepatitis (MASH), and most ageing-associated pathologies^(2,3). The underlying mechanisms that distinguish chronic inflammation from its acute counterpart remain unclear, posing challenges to...
Yu Wang
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