Aging & Longevity

Telomerase, crucial for maintaining telomere integrity and genomic stability, is typically silenced in somatic cells with advancing age. In this study, we identify circHERC1 as a regulator of telomerase reverse transcriptase (TERT) transcription. Specifically, circHERC1 binds to the TERT promoter, facilitating the recruitment of RNA polymerase II and c-Fos, thereby activating TERT expression. Notably, circHERC1 expression exhibits a decline with age, which correlates with reduced telomerase...

Glycogen storage disease (GSD) type IX γ2 is a rare inborn error of metabolism where a defect in glycogenolysis leads to the inability to break down glycogen in the liver. Patients with GSD IX γ2 develop hypoglycemia and advanced liver disease, placing them at risk for liver transplantation. This study evaluates the efficacy of liver-directed AAV gene therapy in a murine model of GSD IX γ2. Phkg2^(-/-) mice underwent treatment with AAV gene therapy (AAV9-LSP-mPhkg2, 5 × 10^(12) vg/kg,...

Time marches endlessly on … but what does that mean for the immune system? Here, investigators discuss how aging impacts the immune response and how immune cells can shape the aging process, with broader implications for modifying immunity to improve not only longevity but also health span.

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CONCLUSION: The results achieved in this study indicate that among older adults experiencing depression, women, those with higher educational levels, and those with existing illnesses are more likely to seek psychological support. Based on these results, it is recommended to develop educational programs to raise societal awareness about the importance of psychological support and to inform health policies accordingly.

Hemokinin-1 (HK-1) regulates several processes in the central and peripheral nervous systems, including musculoskeletal functions; however, its involvement in age-related motor coordination and muscle strength remains unknown. Therefore, these were investigated here with HK-1-deficient mice together with the expression patterns in the mouse and human motor coordination centers. Tac4 gene expression, encoding HK-1, was detected by RNAscope, and its age-dependent changes in the cerebellum and...

Despite extensive research on life-extending interventions, rigorous statistical techniques to determine their impact on compression of morbidity (CoM) are rarely used. We present a case example of an analytical method for examining the effect of life-extending dietary interventions on CoM by comparing the rates of decline in vitality and survival toward the end of life. Using data from previous experimental studies in mice, we calculated the average rate of vitality decline by fitting...

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Accumulating evidence has suggested that intervertebral disc degeneration (IVDD) serves as a health problem deserving attention from worldwide, owing to the low back pain and even disability it causes. Cellular senescence, an irreversible process of terminal cell cycle arrest, plays an essential role in the degeneration of nucleus pulposus (NP) cells and IVDD with an unknown underlying mechanism. Here, we have explored the senescence signature in IVDD through high dimensional weighted gene...

Aging substantially increases susceptibility to sepsis, yet the underlying mechanisms of immune dysfunction in the elderly remain incompletely understood. Polymicrobial sepsis was induced in young and aged male mice via cecal ligation and puncture (CLP). Bone marrow from four groups (Y-Sham, n = 2; Y-CLP, n = 3; A-Sham, n = 2; A-CLP, n = 3) was analyzed by single-cell RNA sequencing and intercellular communication inferred via CellChat. Age-related immune changes were evaluated, and Transwell...

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Tandem light-emitting diodes (LEDs), achieved by vertically stacking multiple units in series to combine the luminance of individual light-emitting elements, are effective for improving efficiency and lifespan compared to single-unit devices^(1-3). In particular, tandem perovskite LEDs benefit from the small Stokes shifts of perovskites⁴, which in principle can enable significant photon recycling between individual perovskite layers and enhance light extraction from trapped modes. However, a...

CONCLUSION: The EcuAging study provides the first evidence on the health of older adults in rural inland Ecuador, highlighting a paradox of preserved physical function alongside impaired mental health. Given that most participants were ≥ 60 years, findings are directly relevant for geriatric populations and underscore the urgent need to strengthen mental health services in rural settings.

CONCLUSION: This longitudinal study suggested that disability and cognition change were bidirectional, with disability showing a stronger impact on future cognitive impairment. Further dynamic investigations and mechanisms between cognitive change and disability are warranted.