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Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration
Giant plume of plasma on the Sun’s surface and more — February’s best science images
How Tiger Worm toilets could help to deliver clean water and sanitation for all
Christophe Boesch (1951–2024), primatologist and chimpanzee champion
The enigmas of language and immunology, and other reads: Books in brief
‘This is my calling’: building point-of-care diagnostic tools to fight tuberculosis
The changing nature of groundwater in the global water cycle
Science, Volume 383, Issue 6686, March 2024.
SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity
Science, Volume 383, Issue 6686, March 2024.
The immunopathological landscape of human pre-TCRα deficiency: From rare to common variants
Science, Volume 383, Issue 6686, March 2024.
Defective pollen tube tip growth induces neo-polyploid infertility
Science, Volume 383, Issue 6686, March 2024.
Native architecture of a human GBP1 defense complex for cell-autonomous immunity to infection
Science, Volume 383, Issue 6686, March 2024.
Puzzling skin side effects stymie advance of promising HIV vaccine
Strategy of multiple, Moderna-made mRNA shots to hone powerful antibodies hits a pothole
After protests, U.S. agency drops plan to limit pesticide use report
U.S. Geological Survey will continue reporting farm use of some 400 compounds
A valid U.S. visa didn’t stop these Chinese graduate students from being deported
Spate of incidents at airports is having a “chilling effect” on those seeking U.S. science Ph.D.s
Is Alzheimer disease a disease?
Dementia, a prevalent condition among older individuals, has profound societal implications. Extensive research has resulted in no cure for what is perceived as the most common dementing illness: Alzheimer disease (AD). AD is defined by specific brain abnormalities - amyloid-β plaques and tau protein neurofibrillary tangles - that are proposed to actively influence the neurodegenerative process. However, conclusive evidence of amyloid-β toxicity is lacking, the mechanisms leading to the...
Electroacupuncture Enhances the Functional Connectivity of Limbic System to Neocortex in the 5xFAD Mouse Model of Alzheimer's Disease
Our previous study revealed that acupuncture may exhibit therapeutic effects on Alzheimer's disease (AD) through the activation of metabolism in memory-related brain regions. However, the underlying functional mechanism remains poorly understood and warrants further investigation. In this study, we used resting-state functional magnetic resonance imaging (rsfMRI) to explore the potential effect of electroacupuncture (EA) on the 5xFAD mouse model of AD. We found that the EA group exhibited...
Effect of gut microbiome modulation on muscle function and cognition: the PROMOTe randomised controlled trial
Studies suggest that inducing gut microbiota changes may alter both muscle physiology and cognitive behaviour. Gut microbiota may play a role in both anabolic resistance of older muscle, and cognition. In this placebo controlled double blinded randomised controlled trial of 36 twin pairs (72 individuals), aged ≥60, each twin pair are block randomised to receive either placebo or prebiotic daily for 12 weeks. Resistance exercise and branched chain amino acid (BCAA) supplementation is prescribed...
Purification of time-resolved insulin granules reveals proteomic and lipidomic changes during granule aging
Endocrine cells employ regulated exocytosis of secretory granules to secrete hormones and neurotransmitters. Secretory granule exocytosis depends on spatiotemporal variables such as proximity to the plasma membrane and age, with newly generated granules being preferentially released. Despite recent advances, we lack a comprehensive view of the molecular composition of insulin granules and associated changes over their lifetime. Here, we report a strategy for the purification of insulin secretory...
Aging and comprehensive molecular profiling in acute myeloid leukemia
Acute myeloid leukemia (AML) is an aging-related and heterogeneous hematopoietic malignancy. In this study, a total of 1,474 newly diagnosed AML patients with RNA sequencing data were enrolled, and targeted or whole exome sequencing data were obtained in 94% cases. The correlation of aging-related factors including age and clonal hematopoiesis (CH), gender, and genomic/transcriptomic profiles (gene fusions, genetic mutations, and gene expression networks or pathways) was systematically analyzed....
Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment
Hypoxia signaling influences tumor development through both cell-intrinsic and -extrinsic pathways. Inhibiting hypoxia-inducible factor (HIF) function has recently been approved as a cancer treatment strategy. Hence, it is important to understand how regulators of HIF may affect tumor growth under physiological conditions. Here we report that in aging mice factor-inhibiting HIF (FIH), one of the most studied negative regulators of HIF, is a haploinsufficient suppressor of spontaneous B cell...