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Science, Volume 387, Issue 6735, February 2025.

Science, Volume 387, Issue 6735, February 2025.

Science, Volume 387, Issue 6735, February 2025.

Science, Volume 387, Issue 6735, February 2025.

Science, Volume 387, Issue 6735, February 2025.

Supervisors deliver bad news across NIH, CDC

The decision brings U.S. poultry farmers a step closer to immunizing their flocks

A court ruling may temporarily ease funding problems, but for many projects the long term outlook remains uncertain

Controversial attorney will oversee vast health research and drug safety programs

Microbiologist Elisabeth Bik donates $200,000 to support training, travel

CONCLUSION: The findings suggest that functional impairments in SMC patients might be associated with disruptions in the global and regional topological organization of the brain's functional connectome, offering new and significant insights into the pathophysiological mechanisms underlying SMC.

CONCLUSIONS AND IMPLICATIONS: Although inpatient mortality is higher in active cancer patients, older adults with active cancer who survive until inpatient geriatric rehabilitation discharge achieve similar functional gains and rates of discharge to the community. Functional improvement is of prognostic value in active cancer patients.

CONCLUSIONS AND IMPLICATIONS: Our findings underscore the complex interplay among physical activity, physical functioning, age, and genetic risk on processing speed. The protective associations of higher PAEE levels and better physical functioning, especially in older APOE4 carriers, suggest that maintaining an active lifestyle and mobility may be crucial for individuals with a genetic predisposition to cognitive decline.

Aging strongly affects the peripheral nervous system (PNS), triggering alterations that vary depending on the innervated tissue. The most frequent alteration in peripheral nerve aging is reduced nerve fiber and glial density which can lead to abnormal nerve functionality. Interestingly, the activation of a destructive phenotype takes place in macrophages across the PNS while a reduced number of neuronal bodies is a unique feature of some enteric ganglia. Single cell/nucleus RNA-sequencing has...

Structural socioeconomic inequality -the aggregate level unequal distribution of resources and opportunities within a region- significantly impacts brain health. Unlike traditional neuroscience approaches that focus on individual factors, recent studies highlight the biological embedding of macrosocial inequalities. We discuss studies on structural inequality that use EEG and f/MRI across diverse populations. Greater structural inequality is associated with adverse brain outcomes, such as...

Fullerene derivatives are widely employed as efficient electron-transporting layers (ETLs) in p-i-n perovskite photovoltaics but face challenges in mitigating interfacial recombination losses and ensuring stable film morphology. Non-fullerene acceptors (NFAs), commonly utilized in organic photovoltaics, present a promising alternative to fullerene-based ETLs. Nevertheless, the suboptimal performance of NFA-based devices underscores the need for molecular engineering to tailor their properties....

Exercise can improve health via skeletal muscle remodeling. Elucidating the underlying mechanism may lead to new therapeutics for aging-related loss of skeletal muscle mass. Here, we show that endurance exercise suppresses expression of YT521-B homology domain family (Ythdf1) in skeletal muscle, which recognizes the N6-methyladenosine (m6A). Ythdf1 deletion phenocopies endurance exercise-induced muscle hypertrophy in mice increases muscle mitochondria content and type I fiber specification. At...

Intervertebral disc degeneration (IVDD) is a leading cause of low back pain, with limited effective treatments due to an incomplete understanding of disease mechanisms. In this study, we report that circFUNDC1, a nuclear circular RNA, is markedly downregulated in nucleus pulposus cells (NPCs) from patients with end-stage IVDD. CircFUNDC1 is derived from the gene encoding the FUN14 domain-containing 1 (FUNDC1) protein, which is essential for mitophagy and cell survival. Functional analyses reveal...

Cellular senescence is a stable cell cycle arrest that occurs in response to various stress stimuli and affects multiple cell types, including endothelial cells (ECs). Senescent cells accumulate with age, and their removal has been linked to reduced age-related diseases. However, some senescent cells are important for tissue homeostasis. Therefore, understanding the diversity of senescent cells in a cell-type-specific manner and their underlying molecular mechanisms is essential. Senescence...

The main aim of this study is to explore the relationship between the elderly population and economic growth in 25 North and South American countries use annual secondary data from 1961 to 2021. Instead of focusing on the conditional mean, this study tests for Granger causality in the entire conditional distribution of the elderly population and economic growth through wavelet coherence analysis. The study findings indicated a unidirectional Granger causality running from per capita gross...