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A ternary-code DNA methylome atlas of mouse tissues

1 month 2 weeks ago
CONCLUSIONS: Our work reveals how tissue, sex, and age jointly govern the dynamics of the two cytosine modifications, augments the scope of DNA modification biomarker discovery, and provides a reference atlas to explore epigenetic dynamics in development and disease.
Sol Moe Lee

Synergistic effects of diabetes and sarcopenic obesity on cardiovascular disease risk in middle-aged and elderly Chinese adults: a large-scale prospective cohort study

1 month 2 weeks ago
CONCLUSIONS: The coexistence of diabetes and sarcopenic obesity synergistically increases cardiovascular disease risk beyond the effects of either condition alone in Chinese adults. These findings highlight the importance of comprehensive screening and integrated management strategies for individuals with both conditions to prevent cardiovascular complications.
Fang Wan

Inflammaging and the sex-frailty paradox

1 month 2 weeks ago
CONCLUSIONS: Trying to delineate the unique molecular profile of older women and men becomes essential for understanding the mechanisms underlying the sex-frailty paradox. Further research on sex-specific determinants is required to enhance our understanding of aging and develop effective strategies to promote health and longevity in both sexes.
Beatrice Arosio

When Melodies Cue Memories: Electrophysiological Correlates of Autobiographically Salient Music Listening in Older Adults

1 month 2 weeks ago
Autobiographical memory is essential for older adults, providing a foundation for self-identity. Although healthy aging is accompanied by changes in memory retrieval, musical memory remains relatively unaffected, suggesting music may serve as a cue for autobiographical memory recall. Autobiographically salient (ABS) music (i.e., deeply encoded songs associated with significant people, places, and events) is posited to engage distinct memory processes from familiar (FAM) music (i.e., songs that...
Veronica Vuong

Cisformer: a scalable cross-modality generation framework for decoding transcriptional regulation at single-cell resolution

1 month 2 weeks ago
Single-cell multiomic technologies enable the joint analysis of different modalities, but face challenges due to experimental complexity. Current computational methods for single-cell cross-modality translation lack biological interpretability. Here, we present Cisformer, a cross-attention-based generative model tailored for cross-modality generation between gene expression and chromatin accessibility at single-cell resolution. Systematic benchmarking demonstrates the superior accuracy and...
Luzhang Ji