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A young progenitor for the most common planetary systems in the Galaxy
A hidden diversity of ceratopsian dinosaurs in Late Cretaceous Europe
A framework for addressing racial and related inequities in conservation
A mysterious ancient fingerprint and a lemon-shaped planet — the stories you’ve missed
Systematic analyses of lipid mobilization by human lipid transfer proteins
Electrochemical defluorinative Matteson-type homologation
‘I rarely get outside’: scientists ditch fieldwork in the age of AI
Why does Denmark recommend so few childhood vaccines? A Danish scientist explains
The U.S. plans to follow the Scandinavian country’s minimalist schedule. That may be a mistake, Jens Lundgren says
Ex–Google CEO funds private space telescope bigger than Hubble
Schmidt Sciences announces investments in orbiting observatory and three ground-based instruments
Why a fatal ‘black fungus’ struck India during the COVID-19 pandemic
Mucormycosis may be triggered by low levels of albumin, the most common blood protein
A timeline of structural and functional consequences to ipRGCs in a mouse model of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects cognitive, sensory and motor systems, including the visual system and has a significant impact on autonomy and quality of life. Emerging evidence suggests that visual system abnormalities may enable early detection and monitoring for AD, appearing before cognitive symptoms. Intrinsically photosensitive retinal ganglion cells (ipRGCs or mRGCs) are among the first neurons affected in AD. This study investigates the...
Accelerated Cognitive Decline in Pain-Insomnia-Depression Syndrome: Longitudinal Evidence and Protective Effects of Healthy Lifestyles
CONCLUSION AND IMPLICATIONS: PIDS and higher cumulative symptom load are associated with accelerated cognitive decline in middle-aged and older adults. Healthy lifestyle adherence mitigates these effects, underscoring integrated strategies combining symptom management with lifestyle interventions to reduce dementia risk.
Acetylation-Dependent Histone H2AX Exchange Suppresses Pathological Senescence via MDC1 Degradation
Cellular senescence has a dual role in both tumor suppression and the promotion of age-related diseases. This paradox suggests the existence of functionally distinct "beneficial" and "detrimental" senescent states, yet the molecular basis that governs their fate has remained elusive. Here, we reveal that the dynamic exchange of histone H2AX on chromatin functions as an essential quality control mechanism that dictates the quality of senescence. We demonstrate that the histone acetyltransferase...
Integrating menopause duration and plasma metabolomics enhances cardiovascular risk stratification in aging women
Menopause-related metabolic remodeling may contribute to the excess cardiovascular disease (CVD) burden in aging women, yet the longitudinal metabolic correlates of time since menopause (TSM) and their prognostic value are unclear. In this prospective analysis of 67,582 postmenopausal women without baseline CVD from the UK Biobank, we profiled 251 plasma metabolites by nuclear magnetic resonance and followed participants for a median 13.7 years (8313 incident CVD events). Elastic net regression...
Mitotic errors as triggers of cell death and inflammation
Bursts of cell proliferation after infection, injury or transformation can coincide with DNA damage and spindle assembly defects. These increase the risk of cell cycle arrest in mitosis, during which many cellular processes are uniquely regulated. Ultimately, cells arrested during mitosis may die, but adaptive mechanisms also allow their escape into the next interphase. This step can have variable consequences, including chromosome missegregation, polyploidization and centrosome amplification....
Changes in transposable elements expression in male and female mice liver throughout aging
Aging has traditionally been studied through the lens of protein-coding genes, with a strong bias toward data derived from male organisms. As a result, the role of non-coding elements and potential sex-specific differences remains largely unexplored. Transposable elements (TEs), mobile sequences capable of altering genome structure and regulating gene expression, have recently gained attention for their roles in development and aging. However, despite this growing interest, key aspects of TE...
The interplay of comorbidity, disability, and physical activity among older adults living with HIV: insights from the CHANGE HIV study
No abstract
Spatial Reorganization of Chromatin Architecture Shapes the Expression Phenotype of Therapy-Induced Senescent Cells
Cellular senescence is a fundamental biological process contributing to aging, often accompanied by extensive chromatin remodeling. Dynamic alterations of three-dimensional (3D) genomic spatial structure, driven by chromatin reorganization, play a critical role in cell fate determination, but their relevance in therapy-induced senescence (TIS) remains underexplored. Here, we perform an integrative multi-omics analysis of Hi-C, ATAC-seq, CUT&RUN, and RNA-seq in primary human fibroblasts...
Chronic stress and the mitochondria-telomere axis: human evidence for a bioenergetic-debt model of early aging
Chronic stress has been linked to mitochondrial dysfunction and impaired telomere maintenance, yet the mechanistic relationships connecting these pathways in humans remain poorly resolved. Using longitudinal findings from the Guillén-Parra cohort as a motivating human example, this Perspective offers a reinterpreted framework that proposes a unifying energetic interpretation in which bioenergetic insufficiency-defined as a mismatch between stress-induced energetic demand and mitochondrial...
TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia
TAR DNA-binding protein 43 (TDP-43) dysfunction is a hallmark of several neurodegenerative diseases, including frontotemporal dementia, amyotrophic lateral sclerosis, and Alzheimer's disease. Although cryptic exon inclusion is a well-characterized consequence of TDP-43 loss of function, emerging evidence reveals broader roles in RNA metabolism, notably in the regulation of alternative polyadenylation (APA) of disease-relevant transcripts. In the present study, we examined 3' untranslated region...