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Study reveals role of “fine-grained” ancestry in predicting response to painkillers, statins, and other drugs

Europe’s Solar Orbiter is helping researchers understand what causes the Sun to blast out radiation and particles

Enigmatic organism known as Prototaxites cannot be fungus, new analysis finds

An unprecedented assault has forced researchers to rethink their advocacy tactics

Mementos may have reinforced vast social networks during turbulent times

Understanding complex interactions in biomedical networks is crucial for advancements in biomedicine, but traditional link prediction (LP) methods are limited in capturing this complexity. We present BioPathNet, a graph neural network framework based on the neural Bellman-Ford network (NBFNet), addressing limitations of traditional representation-based learning methods through path-based reasoning for LP in biomedical knowledge graphs. Unlike node-embedding frameworks, BioPathNet learns...

Senescent cells (SCs) accumulate with aging and contribute to the development of age-related pathologies. These cells evade apoptosis through upregulation of senescent cell anti-apoptotic pathways (SCAPs), making their selective elimination, a strategy termed senolysis, a promising therapeutic avenue. Proteolysis-targeting chimeras (PROTACs) represent an emerging class of bifunctional molecules that exploit the ubiquitin-proteasome system to degrade specific target proteins. By concurrently...