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Water droplets set off a chemical cascade that tells a plant it’s time to blossom, new study finds

Large-scale study finds that simplifying delivery of prevention medication and improving connections to clinics is key

Move comes amid effort to grow the country’s own journals

As new global arms race looms, accusation highlights limits to monitoring low-yield tests

Synaptic Plasticity pertains to the synapse's tendency to adapt fresh information and is a crucial step in the establishment of brain circuits that aid in memory formation. It has become one of the most intensively researched topics in all of neuroscience. Pieces of evidence are accumulating that synaptopathy (altered synaptic plasticity) mechanisms contribute to Alzheimer's disease (AD) and Parkinson's disease (PD). Toxins responsible for synaptopathy and aberrant neurotransmitter (NT) release...

This review synthesizes three decades of evidence regarding the role of cytochrome P450 enzymes (CYPs) in Parkinson's disease (PD), revealing their multifaceted roles beyond traditional pesticide metabolism. While CYP2D6 remains the most studied enzyme due to its association with PD risk in poor metabolizer phenotypes and its dual role in dopamine (DA) synthesis (directly via tyramine hydroxylation and indirectly through precursor demethylation), recent research has highlighted less-studied CYPs...

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Age-related obesity is a growing public health concern linked to various metabolic disorders, yet its underlying mechanisms remain incompletely understood. Here we report that S-nitrosoglutathione reductase (GSNOR), a pivotal denitrosation enzyme, increases in adipose tissue of both male mice and humans from middle-age. GSNOR knockout protects against age-related weight gain and enhances metabolism, whereas adipose-specific GSNOR knock-in mice promotes obesity and metabolic decline. Further...

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Aging impairs immune function and reduces vaccine efficacy, but whether dendritic cells (DCs), which play a central role in initiating immune responses via antigen presentation, contribute to this decline remains unclear. Through single-cell RNA sequencing analysis of lymph node changes upon vaccination in young versus aged mice, here we identify defects in DC migration during aging, alongside a dysfunction-associated gene signature in migratory DCs, and implicate these defects in the diminished...

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CONCLUSIONS: We classified the motion patterns of older adults during diaper wearing. Our results provide fundamental insights into appropriate care and rehabilitation interventions. Furthermore, these findings inform further hypothesis-driven research on diaper-wearing kinematics and support the development of effective strategies to enhance independence diaper use in older adults.

The aging process is predominantly influenced by genetic and environmental factors. Environmental factors that accelerate biological aging, known as gerontogens, increase organismal vulnerability and susceptibility to disease, thereby elevating the risks of multiple aging-related disease onset and mortality. However, there is a notable deficiency in effective biomarkers for predicting aging-related phenotypes accelerated by gerontogens. Melatonin and cortisol serve as markers of the circadian...

The growing ageing population presents significant challenges for healthcare systems, particularly in monitoring age-related physiological decline. Ageing is a complex, multifactorial process that manifests without specific symptoms and is shaped by lifestyle, environmental exposures, diet, and underlying health conditions. Identifying reliable biomarkers of ageing could enable early interventions, improve prognostic accuracy, and reduce healthcare burdens. One promising avenue is exhaled breath...

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