Aggregator

In Other Journals

1 month 2 weeks ago
Science, Volume 390, Issue 6769, Page 142-143, October 2025.
Corinne Simonti, and Jesse Smith, Sacha Vignieri, Ekeoma Uzogara, Mattia Maroso, Madeleine Seale, Ian S. Osborne, Jelena Stajic, and Jack Huang

AMPKα2 signals amino acid insufficiency to inhibit protein synthesis

1 month 2 weeks ago
The functional difference between the two catalytic subunits, α1 and α2, of AMP-activated protein kinase (AMPK) complexes remains elusive. Herein, we report that AMPKα2 specifically transduces amino acid insufficiency signals to protein synthesis. Low amino acid levels, high protein levels, and reduced phosphorylation of AMPKα threonine 172 (p-T172) are observed in blood samples in patients with Alzheimer's disease (AD) from a cohort of 1,000,000 Chinese individuals. Loss of α2, but not α1,...
Yunzi Mao

Extracellular vesicle-based biosensors for Alzheimer's disease: A new frontier in precision diagnostics

1 month 2 weeks ago
Alzheimer's disease (AD), the most prevalent neurodegenerative disorder, remains a diagnostic challenge due to its asymptomatic early stages and the lack of reliable, non-invasive biomarkers. Extracellular vesicles (EVs), including exosomes and microvesicles, are nano-sized membrane-bound particles released by cells into biological fluids and have emerged as promising carriers of disease-specific biomarkers. These vesicles reflect the physiological and pathological state of their parental cells,...
JinJin Pei

Apraxic deficits in Alzheimer's disease are associated with altered dynamic connectivity in praxis-related networks

1 month 2 weeks ago
Apraxia is a common symptom in Alzheimer's disease (AD) that reduces autonomy and quality of life. However, the neural basis underlying apraxia in AD, for example, reflected by functional connectivity (FC) alterations, remains unexplored. We investigated static and dynamic FC using resting-state functional imaging in 14 patients with biomarker-confirmed AD pathology and 14 matched healthy participants. FC was estimated as average (static) and short-term (dynamic) connectivity strengths between...
Taylan D Kuzu

Experimental Evidence Against Taurine Deficiency as a Driver of Aging in Humans

1 month 2 weeks ago
Taurine deficiency was recently proposed as a driver of aging in various species, including humans. To test this hypothesis, we assessed whether circulating taurine was associated with aging and physical performance in 137 physically inactive and physically active men aged 20-93. No association between circulating taurine levels and age, muscle mass, strength, physical performance, or mitochondrial function was observed, thereby challenging the implication of taurine deficiency as a primary...
Vincent Marcangeli