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Spacecraft would release helicopters to explore martian surface

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The question of whether aging should be classified as a disease has gained prominence in geroscience, fueled by advances in molecular biology and the aspiration to develop interventions that mitigate age-associated functional decline. However, evolutionary models describe aging as an emergent consequence of declining selection gradients and life-history trade-offs rather than as a deviation from species-typical function. Comparative data across taxa reveal substantial heterogeneity in aging...

Postural control is expressed as intermittent organization of center-of-pressure (CoP) motion on a saddle-shaped manifold typically aligned with the anteroposterior (AP) and mediolateral (ML) axes. When task demands reorient postural focus, this saddle rotates away from the AP-ML alignment yet preserves orthogonal axes that indicate directions of greatest and least fractal temporal correlations in sway. Preserved orthogonality appears to reflect a balance between endogenous fractal fluctuations...

The identification of functional ligand-membrane protein interactions under native conditions remains a major challenge in cancer biology. Using cell-systematic evolution of ligands by exponential enrichment, we identified a high-affinity DNA aptamer, CW06, against breast cancer cells. To precisely identify its native membrane target, we developed Aptamer-mediated Metabolic Glycan-labeling Proximity Hybridization (Apt-MGPH), which revealed the mitochondrial solute carrier SLC25A24 as the...

Through alternative splicing, the TP53 gene can generate multiple protein isoforms with distinct biochemical properties. The p53psi isoform has been identified as a shorter variant than full-length p53 as it lacks nuclear localization, oligomerization, and part of the DNA binding domains due to the use of an alternative 3' splice site in intron 6. Several TP53-truncating mutations, including those producing p53psi, have been detected in a significant proportion of human tumors. However, the...

CONCLUSIONS AND IMPLICATIONS: Despite methodological variation, community-based programs that reduce loneliness, social isolation, and support aging in place consistently generate positive SROI ratios, benefiting participants, families, and volunteers while reducing health care use. Collaboration among researchers, communities, and policymakers is essential to translate findings into community actions that enable older adults to age in place.

CONCLUSIONS AND IMPLICATIONS: Stable health trajectories are strongly linked to better cognitive outcomes, whereas sharp health declines predict poorer cognition. Our findings highlight the interconnected biological and behavioral pathways through which health changes may accelerate or mitigate cognitive deterioration, offering insights for targeted interventions and holistic care for persons with cognitive impairment.