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Animal-testing alternatives will require a cultural change in research institutions
Ice core reveals longest-ever continuous record of Earth’s climate
UK Biobank breach prompts the field of genomics to rethink open science
Charles Darwin reports a squirrel surprise
Cruise-ship hantavirus cluster exposes a wider preparedness gap
Author Correction: A mechanical ratchet drives unilateral cytokinesis
Author Correction: Predictive coding of reward in the hippocampus
Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan
Brain endothelial cell-derived extracellular vesicles (c-BEEVs) as a promising biomarker for brain vascular pathology and cognitive decline
Somatic variants in microglia-like cells linked to Alzheimer’s disease pathology
Tissue softness unlocks regeneration
Virologist accused of starting COVID-19 will fight U.S. ban on funding
HHS memo says Ralph Baric had a “pattern of deception” in describing virus studies long before pandemic
Most dementia patients have multiple brain diseases. How should they be treated?
Growing awareness of “copathology” inspires new diagnostic tests and clinical trials
Chinese postdocs in U.S. hit with a wave of prosecutions and deportations
The U.S. government has recently convicted multiple postdocs for improper shipments of biological materials. Some see a replay of the 2018 China Initiative
Two skeptics of antidepressant drugs named to NIH mental health council
Pending appointments of Laura Delano and David Cohen raise concerns that key advisory groups are becoming politicized
This simple strength test could predict how long you live
Staying strong may be one of the biggest secrets to living longer — especially for older women. A major study of more than 5,000 women found that simple signs of muscle strength, like a firm hand grip or the ability to quickly stand up from a chair, were strongly linked to lower risk of death over the next eight years.
Scientists say this common sweetener may be quietly rewiring your metabolism
Researchers say fructose is not just “empty calories” — it may actively push the body toward fat storage and metabolic disease. A new review found that fructose affects the body differently from glucose, disrupting normal energy regulation and promoting processes linked to obesity, insulin resistance, and cardiovascular problems.
Advances in modeling memory decline: A critical overview of current animal and human paradigms
Memory decline, particularly in neurodegenerative disorders such as Alzheimer's disease, represents a critical global public health challenge, with projections exceeding 150 million cases by 2050. Current therapeutic options remain limited: while drugs like donepezil and memantine offer symptomatic relief, and newer agents like lecanemab show modest effects on slowing progression, no disease-modifying cures exist. This underscores the urgent need to refine preclinical models bridging discovery...
alpha/Sulfonyl-gamma-AApeptide foldamers mitigate Alzheimer's disease pathology by stabilizing transient helical domains in Abeta
Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ), with soluble oligomers widely recognized as key drivers of neurotoxicity through disruption of synaptic function, mitochondrial integrity, and cellular homeostasis. Targeting Aβ aggregation therefore represents a compelling therapeutic strategy. Here we report a synthetic peptidomimetic foldamer, M4, as a potent modulator of Aβ42 aggregation. Biophysical analyses demonstrate that M4 binds Aβ with high affinity,...
Advances in modeling memory decline: A critical overview of current animal and human paradigms
Memory decline, particularly in neurodegenerative disorders such as Alzheimer's disease, represents a critical global public health challenge, with projections exceeding 150 million cases by 2050. Current therapeutic options remain limited: while drugs like donepezil and memantine offer symptomatic relief, and newer agents like lecanemab show modest effects on slowing progression, no disease-modifying cures exist. This underscores the urgent need to refine preclinical models bridging discovery...