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Lessons from a long road to a first-author paper
Is HRT in menopause healthy? US label change triggers debate
Failure is not an option for Africa’s newly launched medicines agency
High performance tandem perovskite LEDs through interlayer photon recycling
Comprehensive echocardiogram evaluation with view primed vision language AI
How genetically encoded sensors have lit up neuroscience
China’s new scientist visa is a ‘serious bid’ for the world’s top talent
The computers that run on human brain cells
For real climate action, empower women
Be rational: chimp decision-making is guided by the strongest evidence
Academic freedom is key to the future of universities
Kenya’s black rhino revival is a story of hope for conservationists
Insatiable squirrel ravages cherry blossoms for breakfast
COP meetings must evolve to turn climate promises into action
Partnerships between academia and industry must serve the public good
Australia’s unprecedented toxic algal bloom has a surprise culprit
A relatively unknown species is producing a notorious neurotoxin, devastating sea life
New, more stable qubits could simplify dreamed-of quantum computers
Advance underscores the importance of materials science for quantum computing
Arabinoxylan ameliorates memory deficits and amyloid pathology in male 5 × FAD mice via modulation of gut microbiota structure
Alzheimer's disease (AD), a prevalent neurodegenerative disorder, is primarily characterized by β-amyloid (Aβ) deposition. Current therapies alleviate symptoms but lack agents capable of modifying disease progression. Meanwhile, cross-regional studies indicate that AD patients exhibit disrupted gut microbiota composition, which is closely associated with cerebral molecular dysregulation. Building on this gut-brain connection, this study aimed to attenuate AD progression by targeting gut...
Plasma p-tau217 as a biomarker of Alzheimer's disease pathology in individuals with Down syndrome
Diagnosing Alzheimer's disease (AD) in adults with Down syndrome (DS), a population with a high genetically determined risk of AD, remains challenging. In this large observational study including n = 2329 samples from the Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and euploid controls from the Sant Pau Initiative on Neurodegeneration (SPIN) with and without symptomatic AD, we investigate if the strong diagnostic performance of plasma p-tau217 observed in sporadic AD extends to the...
Subsecond dopamine fluctuations do not specify the vigor of ongoing actions
Dopamine (DA) is essential for the production of vigorous actions, but how DA modifies the gain of motor commands remains unclear. Here we show that subsecond DA transients in the striatum of mice are neither required nor sufficient for specifying the vigor of ongoing forelimb movements. Our findings have important implications for our understanding of how DA contributes to motor control under physiological conditions and in Parkinson's disease.