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USC researchers have identified potential new drug compounds that may reduce the brain inflammation linked to Alzheimer’s disease, especially in people with the high-risk APOE4 gene. The compounds target cPLA2, an enzyme that seems to fuel harmful inflammation while also being important for normal brain activity.

Artificial light at night delays winter “shutdown” of mosquitoes carrying disease

Eating more beans, lentils, chickpeas, tofu, and other soy foods could be a surprisingly powerful way to fight high blood pressure. A major analysis of studies from around the world found that people with the highest intake of legumes were 16% less likely to develop hypertension, while those eating the most soy foods had a 19% lower risk.

Past outbreaks spawned clever strategies for testing antivirals and antibodies, but researchers will still face major challenges on the ground

New NIH research reveals that semaglutide sparks different responses inside appetite-controlling brain cells, offering fresh insight into why GLP-1 weight-loss drugs don’t work the same for everyone. Scientists also found a possible way to extend the drugs’ effects, potentially helping patients push past weight-loss plateaus.

A massive international study could upend 40 years of heart attack treatment. Researchers found that beta blockers—routinely prescribed after uncomplicated heart attacks—offered no real benefit for patients whose heart function remained normal, despite being given to millions worldwide. Even more surprising, women taking the drugs faced a higher risk of death, repeat heart attack, or hospitalization for heart failure compared to women who didn’t receive them.

Scientists have uncovered a surprising twist in how cells behave when division goes wrong. Sometimes a cell successfully copies its DNA but fails to split into two, leaving it with double the genetic material — a mistake linked to aging, cancer, and other major diseases. Researchers discovered that not all of these failures are equal.

Spatial omics technologies enable the precise detection of proteins and RNAs at high spatial resolution. Designing spatial omics experiments requires careful consideration of "what" targets to measure and "where" to position the field of views (FOVs). Current FOV sampling strategies often involve acquiring densely sampled FOVs and stitching them together, which is time-consuming, resource-intensive, and sometimes impossible. To optimize FOV sampling strategies, we propose SOFisher, a...

Endogenous double-stranded RNAs (dsRNAs) are immunogenic self-molecules that drive aberrant immune activation under pathological conditions. Here, we show that dsRNAs and their regulation by RNA-binding proteins are key determinants of the fine balance between aging and immunity in Caenorhabditis elegans and cultured human cells. We find elevated levels of dsRNAs with organismal aging and cellular senescence. We identify a moonlighting function for phenylalanyl-tRNA synthetase, FARS-1/FARSA, as...

Time-restricted feeding (TRF), a circadian-based dietary intervention, has emerged as a promising strategy to counteract metabolic and age-related dysfunctions. However, how TRF can reverse stem cell aging and restore tissue regenerative potential remains unclear. In this study, we investigated the effects of long-term TRF on senescent adipose-derived stem cells (ADSCs) in a high-fat diet (HFD) induced aged mice model. Mice were assigned to standard or HFD diets under ad libitum or TRF (8 h/day)...