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Mapping the network structure of dementia and its associated factors among older adults in Singapore: evidence from two national cross-sectional studies
CONCLUSIONS: This study highlights the complex web of interrelations linking dementia with social, behavioural, and health-related factors in later life. Rather than implying causal direction, these findings illustrate how multiple factors cluster and coexist within older adults' lives. These interconnections may inform the design of holistic strategies that integrate employment opportunities, physical activity promotion, social participation, sleep health, and cerebrovascular prevention into...
Cognitive decline and risk of all-cause mortality in older women: a cohort study
CONCLUSION: Cognitive decline over four years was associated with an increased risk of mortality among older women. Further studies should explore whether declines earlier in life or among men are also associated with an increased risk of mortality.
Daily briefing: Around seven hours of sleep slows biological ageing
Does the PSA test for prostate cancer save lives? New data reverse gold-standard findings
Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis
Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer’s disease pathology
NIH staffing shortage could slash number of new grants issued this year
Procrastination, productivity and inspiration: how research is like designing video games
Mental-health research is too often invisible — it is time to change that
Immune cells in the blood drive brain ageing — blocking them improves memory
Hallucinated citations highest in social sciences preprints site
Are we really headed for a ‘super’ El Niño? What the science says
Author Correction: The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis
Author Correction: Postprandial lipid metabolism durably enhances T cell immunity
Who are the Japanese? Huge DNA discovery rewrites history
Scientists analyzing the genomes of thousands of people across Japan discovered evidence for a previously overlooked third ancestral group, challenging the long-accepted “dual origins” theory. The newly identified ancestry appears linked to the ancient Emishi people of northeastern Japan. Researchers also uncovered inherited Neanderthal and Denisovan DNA connected to conditions like diabetes, heart disease, and cancer.
In unreleased document, fired U.S. science board issues stark warning about keeping pace with China
The National Science Board urges robust response to China’s rise in cover letter to its biennial report on the global research enterprise
Did this scientist go too far trying to save Ecuador’s wildlife?
Alejandro Arteaga’s efforts to identify and protect tropical reptiles and amphibians have entangled him in controversy
New psychedelic-like drugs could treat depression without making you trip
UC Davis researchers created brand-new psychedelic-like compounds by shining UV light on amino acid-based molecules. These compounds activated key serotonin receptors tied to brain plasticity and mental health benefits, but surprisingly did not cause hallucination-like behavior in animal tests. Scientists say the discovery could lead to future treatments for depression, PTSD, and addiction without the intense psychedelic experience.
Ghost of long-extinct ancestor lives on in people today
Ancient Homo erectus teeth from China yield protein variants seen in Denisovans—and us
Fluffy ice could imperil spacecraft landings on ocean moons
Water erupted from cryovolcanoes may freeze into thick but fragile layers on Europa and Enceladus