Aggregator
Focal white matter lesions drive grey matter inflammation and synapse loss
Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis
Little ants groom big ones in a desert spa
Meet Ace, the table-tennis robot that can beat elite players
This robot can beat you at table tennis
Ubiquitination of glycogen and metabolites in cells and tissues
Evaluating large language models for accuracy incentivizes hallucinations
The misunderstood sex chromosome: how X affects your health
Meeting the moment: how scientific philanthropies are expanding their reach
Waiting for them
Don’t let your students use AI as a ghostwriter
‘Staggering’ number of people believe unproven claims about vaccines, raw milk and more
How to secure philanthropic funding in a competitive climate
How to impress the Nature Awards judges
Author Correction: Robust cytoplasmic partitioning by solving a cytoskeletal instability
Vaginal bacteria turn newborn skin into a beneficial ‘bioreactor’
A lipid synthesized on skin may promote brain development—and a swabbing with vaginal fluid can provide it to C-section babies, study finds
GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy
Cerebrospinal fluid amyloid beta 42, total tau, and phosphorylated tau 181 are well accepted markers of Alzheimer's disease. These biomarkers better reflect disease pathogenesis compared to clinical diagnosis. Here, we perform a genome wide association study meta-analysis including 18,948 individuals of European ancestry and identify 12 genome-wide significant loci across all three biomarkers, eight of them novel. We replicate the association of biomarkers with APOE, CR1, GMNC/CCDC50 and...
CK2 inhibition suppresses glial inflammation in models of neuroinflammation and neurodegeneration
Neuroinflammation plays a key role in Alzheimer's disease (AD) and many other neurodegenerative disorders. Chronic activation of astrocytes and microglia fuels neuronal damage via cytokine secretion, oxidative stress, and proteolysis, yet glial inflammatory regulation remains poorly understood. Using chemoproteomics, we identified CK2, particularly the brain-enriched catalytic subunit CK2α2, as a key driver of astrocytic inflammation. CK2 enhances NF-κB activity by phosphorylating NF-κB S529 and...
Mild cognitive impairment cases affect the predictive power of Alzheimer's disease diagnostic models using routine clinical variables
Diagnostic models using primary care routine clinical variables have been limited in their ability to identify Alzheimer's disease (AD) patients. In this study, we sought to better understand the effect of mild cognitive impairment (MCI) on the predictive performance of AD diagnostic models. We sourced data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. CatBoost was used to assess the utility of routine clinical variables that are accessible to primary care physicians, such...
Neurons of the human subthalamic nucleus engage with local delta frequency processes during action cancellation
The subthalamic nucleus (STN) is a critical hub for inhibitory control, implicated in decision making under conflict and impulsivity. Delta frequency oscillations have also been associated with inhibitory control processes, yet the relationship between human STN neuronal activity and local delta frequencies during response inhibition remains unresolved. Here we recorded STN neurons and local field potentials in patients with Parkinson's disease performing a stop-signal reaction time task during...