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Swiss cheese materials called metal-organic frameworks can separate and store gases

Researchers are testing multiple treatments for the rare genetic conditions

“Financial drubbing” underscores reliance of some independent research organizations on federal funding

Some theorists think unusual event could be a black hole devouring a star from within

As the global trend of population aging intensifies, frailty among the elderly has emerged as a significant public Health concern. This study examines the relationship between physical activity levels and the Frailty Index in older adults, utilizing data from the 2018 China Health and Retirement Longitudinal Study (CHARLS). The study sample included 10,240 Chinese adults aged ≥ 60 years.Frailty was assessed using the Frailty Index (FI), which was calculated based on the accumulation of...

Traumatic brain injury (TBI) is an environmental risk factor for dementia and long-term neurological deficits, posing a significant public health challenge. TBI-induced neuroinflammation involves both brain-resident microglia and peripheral monocyte-derived macrophages (MDMs). Previous research has shown that MDMs contribute to the development of long-term memory deficits, yet their long-term behavior following brain infiltration remains unclear. To address this, our study uses two complementary...

Living organisms are physical-energetic systems that must obey simple principles guiding energy transformation across physical and temporal scales. The energy resistance principle (ERP) describes behavior and transformation of energy in the carbon-based circuitry of biology. We show how energy resistance (éR) is the fundamental property that enables transformation, converting into useful work the unformed energy potential of food-derived electrons fluxing toward oxygen. Although éR is required...

Impaired autophagy and increased cellular senescence in the aging epididymis may lead to cellular stress, inflammation, and epithelial dysfunction. This reduction in autophagy can be identified using light and electron microscopy, as well as molecular biology techniques. Autophagy, which may be selective or non-selective, is tightly regulated by genes such as LC3 and LAMP-2. Decreased autophagic activity in the epididymis results in reduced sperm quality and male fertility. These findings...

Chrysin (5,7-dihydroxyflavone), a natural flavonoid present in honey, propolis, and various medicinal plants, has shown promise as a calorie restriction mimetic (CRM) through its glycolysis-inhibiting action. This inhibition promotes a metabolic shift toward oxidative phosphorylation and fatty acid oxidation, potentially activating beneficial pathways like AMPK and SIRT1. The mechanism likely involves the downregulation of Hexokinase-2, leading to suppressed glycolysis and promotion of...

Organisms must constantly respond to stress to maintain homeostasis, and the successful implementation of cellular stress responses is directly linked to lifespan regulation. In this Review we examine how three age-associated stressors-loss of proteostasis, oxidative damage and dysregulated nutrient sensing-alter protein synthesis. We describe how these stressors inflict cellular damage via their effects on translation and how translational changes can serve as both sensors and responses to the...

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CONCLUSION: Based on preliminary evidence from this review, lavender may effectively treat sleep disorders, especially in the elderly. However, more research is required to fully understand its effectiveness and safety, especially with long-term use.