Aggregator

SIRT1 Prevents Lens Epithelial Cell Senescence During Age-Related Cataract via Regulating p66Shc

1 month 2 weeks ago
Lens epithelial cell (LEC) senescence is one of the key pathological processes of age-related cataract (ARC) and is associated with oxidative stress, mitochondrial dysfunction, and protein aggregation. This study aimed to elucidate the pathogenesis of LEC senescence in ARC. The protein expression level of silencing regulatory protein 1 (SIRT1) and aptamer protein (p66Shc) was quantified. Reactive oxygen species (ROS) and mitochondrial superoxide levels were measured to evaluate cellular...
Huirui Liu

Cascading land surface hazards as a nexus in the Earth system

1 month 3 weeks ago
Science, Volume 388, Issue 6754, June 2025.
Brian J. Yanites, Marin K. Clark, Joshua J. Roering, A. Joshua West, Dimitrios Zekkos, Jane W. Baldwin, Corina Cerovski-Darriau, Sean F. Gallen, Daniel E. Horton, Eric Kirby, Ben A. Leshchinsky, H. Benjamin Mason, Seulgi Moon, Katherine R. Barnhart, Adam…

Female lineages and changing kinship patterns in Neolithic Çatalhöyük

1 month 3 weeks ago
Science, Volume 388, Issue 6754, June 2025.
Eren Yüncü, Ayça Küçükakdağ Doğu, Damla Kaptan, Muhammed Sıddık Kılıç, Camilla Mazzucato, Merve N. Güler, Elifnaz Eker, Büşra Katırcıoğlu, Maciej Chyleński, Kıvılcım Başak Vural, Ekin Sağlıcan, Gözde Atağ, Defne Bozkurt, Jessica Pearson, Arda Sevkar, N…

In Science Journals

1 month 3 weeks ago
Science, Volume 388, Issue 6754, Page 1381-1383, June 2025.
Michael Funk, and Mark S. Aldenderfer, Sacha Vignieri, Corinne Simonti, Phil Szuromi, Yury Suleymanov, Angela Hessler, Jake S. Yeston, Courtney Malo, Jesse Smith, Peter Stern, Stella M. Hurtley, Di Jiang, Marc S. Lavine, Caroline Ash, Leslie Ferrarelli,…

Without a lifeline

1 month 3 weeks ago
Science, Volume 388, Issue 6754, Page 1362-1367, June 2025.
Catherine Offord