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Ultrastable supported oxygen evolution electrocatalyst formed by ripening-induced embedding

1 month 2 weeks ago
The future deployment of terawatt-scale proton exchange membrane water electrolyzer (PEMWE) technology necessitates development of an efficient oxygen evolution catalyst with low cost and long lifetime. Currently, the stability of the most active iridium (Ir) catalysts is impaired by dissolution, redeposition, detachment, and agglomeration of Ir species. Here we present a ripening-induced embedding strategy that securely embeds the Ir catalyst in a cerium oxide support. Cryogenic electron...
Wenjuan Shi

Genetic and Pharmacological Inhibition of Metabotropic Glutamate Receptor Signalling Extends Lifespan in Drosophila

1 month 2 weeks ago
Invertebrate models have been instrumental in advancing our understanding of the molecular mechanisms of ageing. The isolation of single gene mutations that both extend lifespan and improve age-related health have identified potential targets for therapeutic intervention to alleviate age-related morbidity. Here, we find that genetic loss of function of the G protein-coupled metabotropic glutamate receptor (DmGluRA) in Drosophila extends the lifespan of female flies. This longevity phenotype was...
Cui Guan

Proteasome Augmentation Mitigates Age-Related Cognitive Decline in Mice

1 month 2 weeks ago
The aging brain experiences a significant decline in proteasome function. The proteasome is critical for many key neuronal functions including neuronal plasticity, and memory formation/retention. Treatment with proteasome inhibitors impairs these processes. Our study reveals a marked reduction in 20S and 26S proteasome activities in aged mice brains, including in the hippocampus, this is driven by reduced functionality of aged proteasome. The decline in proteasome activity is matched by a...
Danitra Parker

Negative Effect of Gst-35 on the Health Span of Caenorhabditis elegans Through Lysosomal Dysfunction via the Pmk-1 and Skr Genes

1 month 2 weeks ago
As global life expectancy increases, the focus has shifted from merely extending lifespan to promoting healthy aging. GSTA1, GSTA2, and GSTA3 (GSTA1-3), members of the alpha class of glutathione S-transferases, are involved in diverse biological processes, including metabolism and immune regulation, highlighting their potential influence on human health span and lifespan. In this study, we employed Caenorhabditis elegans as a model organism to investigate the role of gst-35, an ortholog of...
Yehui Gao

Cultural adaptation and validation of the Arabic short version of the Iconographical Falls Efficacy Scale (Icon-FES): Assessing concern about falling among older adults

1 month 2 weeks ago
CONCLUSIONS: The Arabic short version of Icon-FES is a reliable and valid tool for assessing concern about falling among community-dwelling older adults. It offers an innovative approach through culturally adapted visual elements that could enhance applicability, enabling accurate assessment and supporting targeted interventions among Arabic-speaking older adults.
Maha M Almarwani

Measuring thymic output across the human lifespan: a critical challenge in laboratory medicine

1 month 2 weeks ago
Age-associated thymic involution leads to a significant decline in thymic T cell output, a major contributor to immunosenescence in the elderly. Accurately measuring thymic output is therefore critical for understanding the mechanisms behind immune aging. Furthermore, robust quantification of thymic output is essential in various other clinical and research settings, including the diagnosis of immunodeficiencies and the monitoring of T cell reconstitution following therapeutic interventions like...
Vera Middelkamp

RETRACTION: Bmi-1 Plays a Critical Role in Protection From Renal Tubulointerstitial Injury by Maintaining Redox Balance

1 month 2 weeks ago
J. Jin, X. Lv, L. Chen, W. Zhang, J. Li, Q. Wang, R. Wang, X. Lu, and D. Miao, "Bmi-1 Plays a Critical Role in Protection From Renal Tubulointerstitial Injury by Maintaining Redox Balance," Aging Cell 13, no. 5 (2014): 797-809, https://doi.org/10.1111/acel.12236. The above article, published online on 11 June 2014, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Monty Montano; The Anatomical Society; and John Wiley & Sons...

From hypoxic pockets to daily routines: linking brain oxygenation and cognitive resilience

1 month 2 weeks ago
The discovery of hypoxic pockets within the cortical regions has transformed the understanding of cerebral oxygen dynamics, revealing their dual role as both contributors to neuronal adaptation and potential precursors to dysfunction. These transient oxygen-deprived microenvironments play a pivotal role in neurovascular coupling, synaptic plasticity, and angiogenesis, processes crucial for maintaining cognitive resilience and neuronal health. Investigating hypoxic pockets within cortical regions...
Dian Jiao