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Advancing Age and Risk From the Elevated Atherogenic Index: Triglyceride (TG) to High-Density Cholesterol (HDL-C) Ratio

1 month 2 weeks ago
CONCLUSION: The association between the TG/HDL-C ratio (atherogenic index) and incident ASCVD steadily attenuates with age. In adults over 65, an elevated ratio may be associated with a lower risk of incident ASCVD. These findings may reflect changes in metabolic atherosclerotic risk or a survival effect associated with aging and require further investigation.
Manish Kumar

Explaining tip-of-the-tongue experiences in older adults: The role of brain-based and cardiorespiratory fitness factors

1 month 2 weeks ago
Cognitive decline associated with healthy ageing is multifactorial: brain-based and lifestyle factors uniquely and jointly contribute to distinct neurocognitive trajectories of ageing. To evaluate existing models of neurocognitive ageing such as compensation, maintenance, or reserve, we explore how various known brain-based and cardiorespiratory fitness factors intersect to better understand cognitive decline. In a pre-registered study (https://osf.io/6fqg7), we tested 73 healthy older adults...
Foyzul Rahman

Age-related differences in cerebral morphology and microstructure in rhesus macaques

1 month 2 weeks ago
The rhesus macaque presents a promising model for translational research into human brain aging due to this species' long lifespan and close phylogenic relationship. We conducted a cross-sectional study identifying microstructural and morphological biomarkers of aging in a cohort of 37 healthy animals (18F/19M, aged 5-28 years), using high-resolution T2-weighted (T2w) and diffusion-weighted (DW) images. Using Tensor Based Morphometry, significant age-associated regional brain atrophy was...
Alison R Weiss