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Scientists fight Norway’s language law, warning of talent exodus
‘Aqua tweezers’ manipulate particles with water waves
Author Correction: High fatigue resistance in a titanium alloy via near-void-free 3D printing
Japan can be a science heavyweight once more — if it rethinks funding
‘Male-dominated campuses belong to the past’: the University of Tokyo tackles the gender gap
Your brain is full of microplastics: are they harming you?
Federico Mayor Zaragoza obituary: former UNESCO chief who championed neonatal screening
Nature markets are nothing new — they are widespread, regulated and instructive
Scientific societies need to modernize
Close the biodiversity funding gap by teaching conservation to financial professionals
Amazing <i>Australopithecus</i> — excitement from 1925 about a ‘man ape’ fossil find
Outdated rules on expenses prevent academics from travelling more sustainably
Judges suspend NIH plan to slash payments and order health agencies to restore web pages
Lawsuits argued that cutting “indirect cost” rate would have “devastating” impact on research
Why do so many retirement-age scientists keep working?
Survey reveals a desire to hold onto their professional identity keeps Ph.D.s working beyond their 60s
A direct hit
Science, Volume 387, Issue 6736, Page 807-807, February 2025.
Alzheimer’s scientist resigns after university finds ‘data integrity concerns’ in papers
University of Minnesota’s Sylvain Lesné was at the heart of an image-doctoring scandal on study of key amyloid protein linked to dementia
A man was destined for early Alzheimer's - these genes might explain his escape
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Effect of cholinergic modulator in Parkinson's disease with cognitive impairment
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Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia
We conducted an in-depth longitudinal study on an individual carrying the presenilin 2 p.Asn141Ile mutation, traditionally associated with dominantly inherited Alzheimer's disease (AD), who has remarkably remained asymptomatic past the expected age of clinical onset. This study combines genetic, neuroimaging and biomarker analyses to explore the underpinnings of this resilience. Unlike typical progression in dominantly inherited AD, tau pathology in this case was confined to the occipital region...
Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer's disease
Patients with Alzheimer's disease (AD) with little or no quantifiable insoluble brain tau neurofibrillary tangle (NFT) pathology demonstrate stronger clinical benefits of therapies than those with advanced NFTs. The formation of NFTs can be prevented by targeting the intermediate soluble tau assemblies (STAs). However, biochemical understanding and biomarkers of STAs are lacking. We show that Tris-buffered saline-soluble tau aggregates from autopsy-verified AD brain tissues include the core...