Aggregator
Amidination of ligands for chemical and field-effect passivation stabilizes perovskite solar cells
Science, Volume 386, Issue 6724, Page 898-902, November 2024.
Hidden state inference requires abstract contextual representations in the ventral hippocampus
Science, Volume 386, Issue 6724, Page 926-932, November 2024.
Nature of metal-support interaction for metal catalysts on oxide supports
Science, Volume 386, Issue 6724, Page 915-920, November 2024.
Direct hearing measurements in a baleen whale suggest ultrasonic sensitivity
Science, Volume 386, Issue 6724, Page 902-906, November 2024.
Whole-brain spatial transcriptional analysis at cellular resolution
Science, Volume 386, Issue 6724, Page 907-915, November 2024.
Chloronitramide anion is a decomposition product of inorganic chloramines
Science, Volume 386, Issue 6724, Page 882-887, November 2024.
Population connectivity shapes the distribution and complexity of chimpanzee cumulative culture
Science, Volume 386, Issue 6724, Page 920-925, November 2024.
Nature’s gift economies
Science, Volume 386, Issue 6724, Page 858-858, November 2024.
Portraits of the Universe
Science, Volume 386, Issue 6724, Page 857-857, November 2024.
Physicists borrow from origami to extend range of dark matter search
Expandable “metamaterial” makes axion detector more sensitive in higher mass range
Unearthed university investigation found research ethics failings at French medical institute
Studies conducted by Didier Raoult and colleagues flouted French and international ethical standards, report concludes
News at a glance: Russian brain drain, Trump’s nominees, and a long-distance traveler goes extinct
The latest in science and policy
Do ‘blue zones,’ supposed havens of longevity, rest on shaky science?
Critics say extraordinary life spans reflect faulty record keeping, not healthy lifestyles
Light-powered catalysts destroy ‘forever chemicals’
Reactions point toward cheaper remediation of fluorine compounds that contaminate the environment
Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency
Progranulin (PGRN) deficiency is linked to neurodegenerative diseases, including frontotemporal dementia (FTD), Alzheimer's disease, and Parkinson's disease. Proper PGRN levels are critical for brain health; however, the function of PGRN is unclear. PGRN is composed of 7.5 repeat domains, called granulins, and processed into granulins inside the lysosome. PGRN is beneficial for neuronal health, but the role of individual granulins is controversial and unclear. We find that the expression of...
Muscarinic receptors mediate motivation via preparatory neural activity in humans
Motivation depends on dopamine, but might be modulated by acetylcholine which influences dopamine release in the striatum, and amplifies motivation in animal studies. A corresponding effect in humans would be important clinically, since anticholinergic drugs are frequently used in Parkinson's disease, a condition that can also disrupt motivation. Reward and dopamine make us more ready to respond, as indexed by reaction times (RT), and move faster, sometimes termed vigour. These effects may be...
Reduced striatal M4-cholinergic signaling following dopamine loss contributes to parkinsonian and l-DOPA-induced dyskinetic behaviors
A dynamic equilibrium between dopamine and acetylcholine (ACh) is essential for striatal circuitry and motor function, as imbalances are associated with Parkinson's disease (PD) and levodopa-induced dyskinesia (LID). Conventional theories posit that cholinergic signaling is pathologically elevated in PD as a result of increased ACh release, which contributes to motor deficits. However, using approaches to measure receptor-mediated signaling, we found that, rather than the predicted enhancement,...
Erratum for the Research Article "An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease" by A. Ghosh et al
No abstract
Mapping Alzheimer's disease stages toward it's progression: A comprehensive cross-sectional and longitudinal study using resting-state fMRI and graph theory
CONCLUSION: Our findings emphasize significant connectivity alterations across all groups at both baseline and follow-up, with longitudinal analyses underscoring the progression of these changes. Graph theory metrics provide valuable insights into the transition from normal cognition to AD, potentially serving as biomarkers for disease progression.
The new perspective of Alzheimer's Disease Research: Mechanism and therapeutic strategy of neuronal senescence
Alzheimer's disease (AD), commonly known as senile dementia, is a neurodegenerative disease with insidious onset and gradually worsening course. The brain is particularly sensitive to senescence, and neuronal senescence is an important risk factor for the occurrence of AD. However, the exact pathogenesis between neuronal senescence and AD has not been fully elucidated so far. Neuronal senescence is characterized by the permanent stagnation of the cell cycle, and the changes in its structure,...