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Mirror of the unknown: should research on mirror-image molecular biology be stopped?
How should ‘mirror life’ research be restricted? Debate heats up
Smoke-dried mummies pre-date Egypt’s embalmed bodies
Continuous operation of a coherent 3,000-qubit system
Systems Age: a single blood methylation test to quantify aging heterogeneity across 11 physiological systems
A blood DNA methylation test reveals how quickly each organ system is aging
GPS timekeeping is increasingly vulnerable: here’s how to deliver future-proofed time
Heroes or hoarders? The strange brains of people who collect
The chatbots claiming to be Jesus: spreading gospel or heresy?
‘Lipstick on a pig’: how to fight back against a peer-review bully
Weird ‘time crystals’ are made visible at last
Sweet like chocolate: researching in the shade of a cacao tree
Publisher Correction: Experimental determination of partial charges with electron diffraction
Ready or not, the digital afterlife is here
After bizarre journey, prized history of molecular biology archive finds new home
Science History Institute makes public multimillion-dollar collection, including Rosalind Franklin’s famous DNA image, assembled by fake scientist
Scientists decry NIH pledge to end some human fetal tissue research
Move could signal return to ban on such studies imposed by first Trump administration
A review of the TGF-beta1 pathway in Alzheimer's disease and depression: Possible restoration potential of antidepressants
Alzheimer's Disease (AD), the most common type of dementia, is increasing rapidly in prevalence, while Major Depressive Disorder (MDD), the most frequent psychiatric condition, continues to pose significant global healthcare challenges. Recent hypotheses suggest that AD and MDD might be interrelated, potentially sharing common pathophysiological mechanisms. One possible central link is the Transforming Growth Factor-beta 1 (TGF-β1) pathway. Reduced TGF-β1 levels, a cytokine involved in...
Osteoporosis
Osteoporotic fractures are one of the most common and consequential diseases of advanced ageing and many antifracture therapies are widely available but largely underused. This Seminar presents an updated approach to osteoporosis consultation, drawing upon published evidence and collaborative expert opinion to place the data in a pragmatic and useful context for clinicians. New evidence on osteoporosis screening recommendations, fracture-risk assessment, intervention decisions, nutrition-based...
A review of the TGF-β1 pathway in Alzheimer's disease and depression: Possible restoration potential of antidepressants
Alzheimer's Disease (AD), the most common type of dementia, is increasing rapidly in prevalence, while Major Depressive Disorder (MDD), the most frequent psychiatric condition, continues to pose significant global healthcare challenges. Recent hypotheses suggest that AD and MDD might be interrelated, potentially sharing common pathophysiological mechanisms. One possible central link is the Transforming Growth Factor-beta 1 (TGF-β1) pathway. Reduced TGF-β1 levels, a cytokine involved in...
Selenium and brain aging: A comprehensive review with a focus on hippocampal neurogenesis
Brain aging is accompanied by progressive cognitive decline and increased risk of neurodegenerative diseases, with adult hippocampal neurogenesis (AHN) playing a pivotal role in maintaining cognitive resilience. Selenium, an essential trace element, exerts significant neuroprotective and neurogenic effects predominantly through its incorporation into selenoproteins, which regulate oxidative stress, neuroinflammation, and synaptic plasticity. This review synthesizes recent advances delineating...