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Hippocampal iron patterns in aging and mild cognitive impairment
INTRODUCTION: The entorhinal cortex (EC)-hippocampus system is critical for memory and affected early in Alzheimer's disease (AD). Cognitive dysfunction in AD is linked to neuropathological changes, including non-heme iron accumulation in vulnerable brain regions. This study characterized iron distribution in the EC-hippocampus system using ultra-high field (UHF) magnetic resonance imaging (MRI) at 7 Tesla (T) in aging and mild cognitive impairment (MCI), an AD at-risk state.
Characterizing changes to individual-specific brain signature with age
The increasing prevalence of neurodegenerative diseases in an aging population underscores the critical need for reliable biomarkers distinguishing normal aging from pathological neurodegeneration. This study leverages neuroimaging to identify age-resilient biomarkers, establishing a baseline of neural features that are relatively stable across the aging process. Our research objectives are threefold: (a) Validate a methodology using leverage scores to identify age-robust neural signatures; (b)...
Examining the independent and moderating effects of arterial stiffness and cerebral blood flow on total hippocampal and hippocampal subfield volumes
CONCLUSION: Increased arterial stiffness and reduced CBF were not independently associated with smaller HV. However, in combination, persistently elevated AS and reduced CBF is associated with smaller HV. These effects were equally exerted across all hippocampal subfields tested. Our findings suggest a lag effect in the arterial stiffness and hippocampal volume relationship. We propose that the subsequent reduction in cerebral blood flow observed with elevated arterial stiffness may be the...
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Science, Volume 389, Issue 6757, July 2025.
Erratum for the Research Article “Sunlight drives the abiotic formation of nitrous oxide in fresh and marine waters” by E. Leon-Palmero et al.
Science, Volume 389, Issue 6757, July 2025.
Redox-regulated Aux/IAA multimerization modulates auxin responses
Science, Volume 389, Issue 6757, July 2025.
Design of intrinsically disordered region binding proteins
Science, Volume 389, Issue 6757, July 2025.
Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning
Science, Volume 389, Issue 6757, July 2025.
Vaccination to mitigate climate-driven disruptions to malaria control in Madagascar
Science, Volume 389, Issue 6757, July 2025.
Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders
Science, Volume 389, Issue 6757, July 2025.