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The aging male: impact of aging on male reproduction
Aging is a complex process that includes chronological aging and cellular aging. Although chronological aging is irreversible, cellular aging, which is reversible, is closely associated with chronological aging. Understanding the complexity of the impact and mechanisms of aging on the male reproductive function is crucial in maintaining male fertility. This study reviews the effects and mechanisms associated with aging in males on male reproductive health. It also provides potential therapeutic...
Daily briefing: Wildlife wonders and a Super Heavy — the month’s best science images
Powerful new antibiotic that can kill superbugs discovered in soil bacteria
Personalized gene editing helped one baby: can it be rolled out widely?
Longer walks beat shorter strolls for heart health
Too much social media gives AI chatbots ‘brain rot’
Please stay out of the abandoned buildings
Why India’s controversial ‘cloud seeding’ trial failed to make it rain
Secret route to warm cosmic ‘inflation’: the nuclear force
Forests’ misty breath sustains crops in distant lands
Artificial brains with less drain
Adapting health, economic and social policies to address population aging in China
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial
A flood of Chinese graduate students in STEM was a boon to U.S. students
Study shows the influx allowed U.S. programs to expand enrollment and also benefited local businesses
Egypt joins Europe’s flagship science program, raising academic freedom concerns
Horizon Europe’s push for free inquiry clashes with Egypt’s human rights record, critics say
Mini-tyrannosaur lived alongside <em>T. rex</em>, extraordinary fossil confirms
Study finds fresh evidence for Nanotyrannus, a dinosaur whose existence has long been debated
How one of the world’s rarest and most valuable gemstones gets its vivid colors
Scientists finally solve mystery of ammolite’s brilliant reds, greens, and blues
Effects of protein-based multinutrient therapy on sarcopenia in older adults: a systematic review and meta-analysis
CONCLUSIONS: Protein-based multinutrient therapy significantly improved HGS, GS, and IGF-1 levels in patients with sarcopenia, but showed no significant effects on SPPB scores, chair-stand time, or SMI. The included studies were generally of high quality, and the results are relatively reliable, however, more high-quality RCTs are needed for further validation.
Fr-AGILE: validation and reliability of a multidimensional and rapid frailty assessment tool in the Turkish elderly population
CONCLUSION: The Fr-AGILE scale is a valid and reliable tool for rapid, multidimensional frailty assessment in older adults. It provides a practical and efficient method for identifying frailty across physical, mental, nutritional, and socioeconomic domains in Turkish geriatric patients.
Proteomic polygenic risk scores of age-related plasma protein levels reveal a role for Metalloproteinase inhibitor 2 (TIMP2) in cognitive performance
Several studies in mice have identified blood proteins that influence brain aging, yet translating these findings into humans remains challenging. To address this gap, we conducted a systematic review that identified 12 proteins reported to have an aging or rejuvenating effect in murine brains. Using protein quantitative trait loci data, we computed proteomic polygenic risk scores (protPRSs) capturing the lifelong genetic predisposition to higher or lower plasma protein levels and their...