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Mediating role of brain aging in the effect of white matter hyperintensities on post-stroke aphasia severity
CONCLUSION: Our findings highlight the influence of neuroanatomical aging and WMH burden on post-stroke language deficits, supporting the consideration of both brain-PAD and WMH severity when assessing aphasia severity to inform clinical assessment and treatment planning.
Differential effects of physical activity on behavioral and prefrontal responses during repetitive inhibitory control in older adults
CONCLUSION: Regular physical activity may enhance cognitive adaptability and selective inhibition in older adults. Behavioral improvements were more evident than neural differences between the groups, highlighting the potential of everyday physical activity to support cognitive resilience in aging. This study provides neurophysiological evidence supporting the integration of physical activity into cognitive intervention strategies for older populations.
LOU/c/jall rat as a model of resilience in the context of streptozotocin-induced cognitive impairment
INTRODUCTION: The concept of cognitive resilience (CR) has emerged to explain the lack of correlation between the extent of brain lesions and the severity of cognitive symptoms in Alzheimer's disease (AD), but the underlying mechanisms remain poorly understood.
Liu Jun Zi Decoction extends lifespan and healthspan through p16/p21 signaling in Caenorhabditis elegans
Age-related functional decline has emerged as a major challenge to human health and societal development. Safe and effective anti-aging interventions, particularly those involving natural products, offer promising strategies to delay aging and promote healthy longevity. In this study, we used Caenorhabditis elegans (C. elegans) models to investigate the anti-aging effects and underlying mechanisms of Liu Jun Zi Decoction (LJZD), a traditional Chinese herbal formula. The results showed that LJZD...
Antibodies unleashed against pancreatic cancer
Daily briefing: Custom-made gene-editing therapy for children to enter clinical trial
My funding applications are taking up too much time. How can I stay focused on my research?
‘Memory foam’ skeleton in cells helps them to navigate
Alzheimer’s decline slows with just a few thousand steps a day
How to fight climate change without the US: a guide to global action
From pangolins to primates: how I use zoo facilities to treat wild animals
Accelerating the discovery of multicatalytic cooperativity
Independent mechanisms of inflammation and myeloid bias in VEXAS syndrome
A versatile cohesion manipulation system probes female reproductive age-related egg aneuploidy
‘Biotech Barbie’ says the time has come to consider CRISPR babies. Do scientists agree?
Insiders warn how dismantling federal agencies could put science at risk
PhD training needs a reboot in an AI world
Sex, drugs and the conscious brain: Francis Crick beyond the double helix
Letters to scientific journals surge as ‘prolific debutante’ authors likely use AI
New study reinforces worries about “mass production of junk” by unscrupulous scholars aiming to pad their CVs
Oligo fucoidan alleviates sarcopenia via attenuating muscle mass loss and function decline in senescence-accelerated mouse prone 8 mice
CONCLUSION: Our findings show that OliFuco is a promising nutritional intervention for mitigating sarcopenia by preserving muscle mass and function in aging populations, offering a novel strategy to address age-related muscle decline.