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Loss of Earth's old, wise, and large animals
Earth's old animals are in decline. Despite this, emerging research is revealing the vital contributions of older individuals to cultural transmission, population dynamics, and ecosystem processes and services. Often the largest and most experienced, old individuals are most valued by humans and make important contributions to reproduction, information acquisition and cultural transmission, trophic dynamics, and resistance and resilience to natural and anthropogenic disturbance. These...
Amidination of ligands for chemical and field-effect passivation stabilizes perovskite solar cells
Surface passivation has driven the rapid increase in the power conversion efficiency (PCE) of perovskite solar cells (PSCs). However, state-of-the-art surface passivation techniques rely on ammonium ligands that suffer deprotonation under light and thermal stress. We developed a library of amidinium ligands, of interest for their resonance effect-enhanced N-H bonds that may resist deprotonation, to increase the thermal stability of passivation layers on perovskite surfaces. This strategy...
Shades of blue
Blue zones, supposed havens of longevity, have become a global brand. But skeptics think they rest on shaky science.
Adaptation, calibration, and validation of a cognitive assessment battery for telephone and video administration
CONCLUSIONS: Videoconference based neuropsychological assessment can be as precise as in-person. Calibration of ability estimates using latent variable measurement models can address measurement differences and generate scores without evidence of systematic bias.
Cognitive aging and reserve factors in the Metropolit 1953 Danish male cohort
Identifying early predictors of cognitive decline and at-risk individuals is essential for timely intervention and prevention of dementia. This study aimed to detect neurobiological changes and factors related to cognitive performance in the Metropolit 1953 Danish male birth cohort. We analyzed data from 582 participants, aged 57-68 years, using machine learning techniques to group cognitive trajectories into four clusters differentiating high- and low-performing groups. These clusters were then...
Isolating the direct effects of growth hormone on lifespan and metabolism in mice
Prior studies have shown that interrupting the growth hormone/insulin-like growth factor-I (GH/IGF-I) signaling axis extends laboratory mouse lifespan, but confounding effects of additional gene or hormone deficiencies that exist in commonly used models of GH/IGF-I interruption obscure the specific effect of GH on longevity. We address this issue by using mice with a specific knockout of the GH gene and show that both males and females on a mixed genetic background display extended lifespans...
Daily briefing: Why the man behind a ‘mouse utopia’ disappeared from the scientific literature
‘A place of joy’: why scientists are joining the rush to Bluesky
Notching up a win: fresh tools for activating Notch
I had three children during my PhD: here’s what I learnt
Next-generation snakebite therapies could reduce death toll
Chimps tickle and wrestle in play to pave the way for teamwork
Bacteria found on a space rock turn out to be Earth-grown
Synergistic photobiocatalysis for enantioselective triple radical sorting
Exome sequencing in Asian populations identifies low-frequency and rare coding variation influencing Parkinson’s disease risk
Scientists as political advocates
Science, Volume 386, Issue 6724, November 2024.
AI could pose pandemic-scale biosecurity risks. Here’s how to make it safer
New schizophrenia drug could treat Alzheimer’s disease
In Science Journals
Science, Volume 386, Issue 6724, Page 862-864, November 2024.
An institution-level analysis of gender gaps in STEM over time
Science, Volume 386, Issue 6724, Page 853-856, November 2024.