Aggregator

CONCLUSION: The worsening of frailty with age is more common in older adults than the improvement of frailty. Among robust and pre-frail individuals, older women are more likely to experience a deterioration in frailty status. The factors influencing frailty transitions are multifaceted and complex. Therefore, when intervening in the progression of frailty among older adults, it is essential to comprehensively assess frailty risks and influencing factors based on the diverse characteristics and...

CONCLUSIONS: In order to prevent accident-related deaths, it is important to take protective measures and facilitate access to emergency medical services for geriatric individuals, especially those with chronic diseases. This is particularly important for preventing traffic accidents in urban areas and firearm and animal attacks in rural areas. Examining the causes and risk factors of accident-related deaths in the older population can promote healthier ageing. This study provides important data...

Aging is a key driver of cardiac dysfunction, promoting structural remodeling, metabolic alterations, and loss of cellular resilience. In aged hearts, extracellular matrix remodeling and collagen accumulation reduce ventricular compliance, impairing both diastolic function and stress adaptability. Cardiomyocytes exhibit diminished regenerative capacity and dysregulated stress responses, with mitochondrial dysfunction emerging as a central contributor to energy imbalance, oxidative stress, and...

Traumatic brain injuries (TBIs) are a global source of hospitalization, long-term disability, and death. However, age, sex, and other demographics differ widely among patients and the variable characteristics of TBIs further obscure injury outcomes. Here, we used Drosophila melanogaster to assess the effects of mild, repeated TBI (multi-day, MD) compared to single, severe TBI (single-day, SD). In all genotypes tested, flies given an SD injury exhibited higher acute mortality, but in some...

Tendon degeneration is common, and its risk increases with age both in humans and horses. Tendon regeneration and healing is limited due to inherent low cell density and vascularisation, and current treatments are insufficient as indicated by scar tissue formation and a high re-injury rate. The tendon vasculature plays a crucial role in tendon homeostasis, regeneration and healing, making it a potential therapeutic target. However, the effect of ageing on the tendon microvasculature is poorly...