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Climate change shifts the North Pacific storm track polewards
High-voltage anode-free sodium–sulfur batteries
An expanded registry of candidate <i>cis</i>-regulatory elements
Plastic landmark anchoring in zebrafish compass neurons
RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity
Surface optimization governs the local design of physical networks
A young progenitor for the most common planetary systems in the Galaxy
A hidden diversity of ceratopsian dinosaurs in Late Cretaceous Europe
A framework for addressing racial and related inequities in conservation
A mysterious ancient fingerprint and a lemon-shaped planet — the stories you’ve missed
Systematic analyses of lipid mobilization by human lipid transfer proteins
Electrochemical defluorinative Matteson-type homologation
‘I rarely get outside’: scientists ditch fieldwork in the age of AI
Why does Denmark recommend so few childhood vaccines? A Danish scientist explains
The U.S. plans to follow the Scandinavian country’s minimalist schedule. That may be a mistake, Jens Lundgren says
Ex–Google CEO funds private space telescope bigger than Hubble
Schmidt Sciences announces investments in orbiting observatory and three ground-based instruments
Why a fatal ‘black fungus’ struck India during the COVID-19 pandemic
Mucormycosis may be triggered by low levels of albumin, the most common blood protein
A timeline of structural and functional consequences to ipRGCs in a mouse model of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects cognitive, sensory and motor systems, including the visual system and has a significant impact on autonomy and quality of life. Emerging evidence suggests that visual system abnormalities may enable early detection and monitoring for AD, appearing before cognitive symptoms. Intrinsically photosensitive retinal ganglion cells (ipRGCs or mRGCs) are among the first neurons affected in AD. This study investigates the...
Accelerated Cognitive Decline in Pain-Insomnia-Depression Syndrome: Longitudinal Evidence and Protective Effects of Healthy Lifestyles
CONCLUSION AND IMPLICATIONS: PIDS and higher cumulative symptom load are associated with accelerated cognitive decline in middle-aged and older adults. Healthy lifestyle adherence mitigates these effects, underscoring integrated strategies combining symptom management with lifestyle interventions to reduce dementia risk.
Acetylation-Dependent Histone H2AX Exchange Suppresses Pathological Senescence via MDC1 Degradation
Cellular senescence has a dual role in both tumor suppression and the promotion of age-related diseases. This paradox suggests the existence of functionally distinct "beneficial" and "detrimental" senescent states, yet the molecular basis that governs their fate has remained elusive. Here, we reveal that the dynamic exchange of histone H2AX on chromatin functions as an essential quality control mechanism that dictates the quality of senescence. We demonstrate that the histone acetyltransferase...
Integrating menopause duration and plasma metabolomics enhances cardiovascular risk stratification in aging women
Menopause-related metabolic remodeling may contribute to the excess cardiovascular disease (CVD) burden in aging women, yet the longitudinal metabolic correlates of time since menopause (TSM) and their prognostic value are unclear. In this prospective analysis of 67,582 postmenopausal women without baseline CVD from the UK Biobank, we profiled 251 plasma metabolites by nuclear magnetic resonance and followed participants for a median 13.7 years (8313 incident CVD events). Elastic net regression...