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The cat diaspora out of Africa
Science, Volume 390, Issue 6776, Page 881-882, November 2025.
Groove to the music
Science, Volume 390, Issue 6776, Page 884-885, November 2025.
Platform-independent experiments on social media
Science, Volume 390, Issue 6776, Page 883-884, November 2025.
How does glacier flow vary by season?
Science, Volume 390, Issue 6776, Page 886-886, November 2025.
In Other Journals
Science, Volume 390, Issue 6776, Page 896-897, November 2025.
A fish story
Science, Volume 390, Issue 6776, Page 954-954, November 2025.
Seasonal dynamics of Earth’s glaciers and ice sheets
Science, Volume 390, Issue 6776, Page 945-950, November 2025.
Laser annealing enables rapid, degradation-free ambient processing of perovskite solar modules
Science, Volume 390, Issue 6776, Page 905-910, November 2025.
Elasticity of davemaoite as a primary contributor to lower-mantle heterogeneities
Science, Volume 390, Issue 6776, Page 935-939, November 2025.
Realization of three- and four-body interactions between momentum states in a cavity
Science, Volume 390, Issue 6776, Page 925-929, November 2025.
Rapid compensatory evolution within a multiprotein complex preserves telomere integrity
Science, Volume 390, Issue 6776, Page 918-924, November 2025.
Programmable higher-order nonequilibrium topological phases on a superconducting quantum processor
Science, Volume 390, Issue 6776, Page 930-934, November 2025.
Monkeys have rhythm
Science, Volume 390, Issue 6776, Page 940-944, November 2025.
Whither the world’s winds
Science, Volume 390, Issue 6776, Page 888-888, November 2025.
A human history of machines
Science, Volume 390, Issue 6776, Page 887-887, November 2025.
‘Superarm’ helps male octopuses deliver sperm to females
Specialized appendage responds to female sex hormones, allowing males to find sex organs in the dark
Russia’s plan for ‘colossal’ science spending boost faces skepticism
Government pledges to more than triple research spending by 2030
Insulin resistance as a mediator of physical activity's effects on beta-amyloid accumulation and tau phosphorylation: A scoping review
CONCLUSION: Exercise can simultaneously impact insulin resistance and Alzheimer's disease pathology in animal models. Results from human research are limited, and no robust evaluation of the potential mediating role of insulin resistance in the physical activity - Aβ or tau relationship exists. Future research should focus on identifying the mediating pathways that may link physical activity to biomarkers of Alzheimer's disease.
Pharmacologic inhibition of PCBP2 biomolecular condensates relieves Alzheimer's disease
Biomolecular condensates, membrane-less assemblies formed by phase separation, are implicated in neurodegenerative disease, but their role in Alzheimer's disease (AD) remains unclear. Here, we report that in the brain of AD patients and animal models, an elevation of poly(C)-binding protein 2 (PCBP2) correlates with biomolecular condensation that involves phase separation. These condensates sequester large numbers of mitochondrial and mRNA-binding proteins, leading to the outside impairment of...
Integrating axis quantitative trait loci looks beyond cell types and offers insights into brain-related traits
Genome-wide association studies have identified many loci for brain disorders, but most non-coding variants fail to colocalize with bulk expression quantitative trait loci. Single-cell expression quantitative trait loci studies capture cell-type-specific regulation but are often underpowered. We developed Bulk And Single cell expression quantitative trait loci Integration across Cell states (BASIC) to combine bulk and single-cell expression quantitative trait loci through "axis-quantitative...