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In search of meaning
Science, Volume 391, Issue 6787, Page 762-763, February 2026.
Black holes disguised as little red dots
Science, Volume 391, Issue 6787, Page 767-768, February 2026.
In Other Journals
Science, Volume 391, Issue 6787, Page 778-779, February 2026.
An instructive experiment
Science, Volume 391, Issue 6787, Page 842-842, February 2026.
Evolution of error correction through a need for speed
Science, Volume 391, Issue 6787, Page 818-824, February 2026.
Toward universal steering and monitoring of AI models
Science, Volume 391, Issue 6787, Page 787-792, February 2026.
Single-molecule infrared spectroscopy with scanning tunneling microscopy
Science, Volume 391, Issue 6787, Page 807-811, February 2026.
Simple unilateral rupture of the great Mw 8.8 2025 Kamchatka earthquake
Science, Volume 391, Issue 6787, Page 812-817, February 2026.
Empathy and prosocial behavior powered by orexin-driven theta oscillations
Science, Volume 391, Issue 6787, Page 800-806, February 2026.
Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization
Science, Volume 391, Issue 6787, Page 825-830, February 2026.
The oncogenome of the domestic cat
Science, Volume 391, Issue 6787, Page 793-799, February 2026.
Matching sounds to shapes: Evidence of the bouba-kiki effect in naïve baby chicks
Science, Volume 391, Issue 6787, Page 836-839, February 2026.
Creature comforts
Science, Volume 391, Issue 6787, Page 772-772, February 2026.
Playing the game of science
Science, Volume 391, Issue 6787, Page 773-773, February 2026.
Unorthodox ‘universal vaccine’ offers broad protection in mice
Immune-stimulating cocktail could shield against diverse bacterial and viral infections
A little-known flu virus is sickening cattle around the world. Are humans next?
Features of recently identified influenza D point to possible pandemic threat
Enhancing diagnosis of mild cognitive impairment through brain-heart-gut metabolic networks in whole-body PET imaging
Mild cognitive impairment (MCI) is the prodromal stage of dementia involving complex interactions between the brain and peripheral organs. Emerging evidence indicates that heart dysfunction and gut microbiota dysbiosis contribute to MCI pathogenesis. Here, we present a framework integrating brain-heart-gut interactions using whole-body positron emission tomography (PET) to enhance brain-only diagnostic performance. Our brain-only model achieves diagnostic performance comparable to that of...
Anti-ASC antibodies alleviate Alzheimer's disease-type pathology in APP/PS1 mice
CONCLUSIONS: The anti-ASC N-terminal and C-terminal antibodies may have neuroprotective effects, which are manifested as reducing cell apoptosis, improving cognitive function, and alleviating AD-like pathology in AD mice. Immunotherapies targeting ASC are promising for treating AD.
Hallucinogenic Therapy in Alzheimer's Disease targeting Mitochondria-Associated Membranes
Mitochondrial dysfunction is increasingly recognized as a central driver of Alzheimer's disease (AD), contributing to neuroinflammation, synaptic failure, and energy collapse.Emerging preclinical evidence suggests that classic hallucinogens, such as psilocybin, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT), mescaline, may restore mitochondrial integrity by activating Serotonin 2A (5-HT2A) and sigma-1(Sig-1R) receptors. In experimental models, these pathways are associated with...
Structural defects in amyloid-β fibrils drive secondary nucleation
Formation of new amyloid fibrils and oligomers from monomeric protein on the surfaces of existing fibrils is an important driver of many disorders such as Alzheimer's and Parkinson's diseases. The structural basis of this secondary nucleation process, however, is poorly understood. Here, we ask whether secondary nucleation sites are found predominantly at rare growth defects: irregularities in the fibril core structure incorporated during their original assembly. We first demonstrate using the...