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Single Cell Sequencing Identifies Distinct Cellular Alterations in Impaired Aged and Diabetic Wounds

3 weeks 4 days ago
Impaired wound healing in aged and diabetic wounds involves complex cellular dysregulation that hinders tissue repair. Using single-cell RNA sequencing (scRNA-seq) and validation techniques, we investigated impaired wound healing to identify whether there were significant changes linked to each condition. Comparative mucosal wound analysis revealed distinct differences between diabetic and normoglycemic (NG)-aged mice, which had an impact on connective tissue formation and epithelial closure....
Leticia Rojas Cortez

Oscillatory dynamics of motor learning across adulthood life span: a systematic review

3 weeks 4 days ago
Motor learning refers to a set of processes associated with practice and experience that are essential for acquiring new skills and adapting behavior throughout the lifespan. Mastery of motor skills plays a crucial role in maintaining autonomy and quality of life, particularly in aging populations. This learning process relies on internal neural mechanisms that lead to enduring changes in movement capability, yet the underlying functional and anatomical adaptations in sensorimotor circuits...
Amir Jahanian-Najafabadi