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Science, Volume 391, Issue 6785, Page 622-627, February 2026.

Science, Volume 391, Issue 6785, Page 604-610, February 2026.

Science, Volume 391, Issue 6785, Page 611-615, February 2026.

Science, Volume 391, Issue 6785, Page 583-586, February 2026.

Science, Volume 391, Issue 6785, Page 562-562, February 2026.

Science, Volume 391, Issue 6785, Page 563-563, February 2026.

Researchers say they couldn’t find complete data for 10 trials that together enrolled tens of thousands of children in Guinea-Bissau

Coatings used by symbiotic residents of ant colonies may represent an evolutionary dead end

Team in China sends data with entangled atoms, neutralizing backdoor hardware threats

Finerenone boosts ovary function in mice and appears to help people with primary ovarian insufficiency produce mature eggs

Kanzi, a bonobo studied for his language skills, understood make-believe objects

Developed by and for academics, OpenScholar aims to improve searches of the ballooning scientific literature

How the memory engram is organized at the cell-assembly level to support not only encoding of learned information but also memory flexibility remains elusive. Here, we propose a novel engram model encoded by two orthogonal learning-recruited neuronal ensembles in the mouse dentate gyrus. Reactivation of the Fos-tagged ensemble promotes memory retrieval, whereas reactivation of the Npas4-dependent ensemble drives forgetting, with manipulation of the forgetting ensemble inversely shifting memory...

The native microbiome influences numerous host processes, including neurological function. However, its impacts on diverse brain cell types remain poorly understood. Here, we performed single-nucleus RNA sequencing on the hippocampus of wild-type, germ-free mice, revealing the microbiome-dependent transcriptional landscape across all major neural cell types. We found conserved impacts on key adaptive immune and neurodegenerative transcriptional pathways. Mono-colonization with select indigenous...

Recent advances in high-throughput technologies have led to an increased generation of biological data across genomics, transcriptomics, proteomics, epigenomics, and metabolomics. However, a major challenge remains: effectively integrating these multi-omics datasets to allow a more holistic understanding of the complex, interconnected mechanisms underlying human diseases. Neurodevelopmental, neurodegenerative, and psychiatric disorders are particularly multifactorial and heterogeneous, making...

Deep brain stimulation (DBS) is effective for treating neurological and psychiatric disorders. However, its tethered configuration, invasiveness, and limited tissue compatibility motivate wireless, minimally invasive alternatives. Here, we develop an in situ-gelled injectable conductive hydrogel (ICH), enabling wireless neuromodulation via electric-field localization under volume conduction. The ICH forms in vivo through bio-catalyzed polymerization and electrostatic self-assembly, yielding a...

Parkinson's disease (PD) is an incurable neurological disorder that often begins insidiously with sleep disturbances and somatic symptoms, progressing to whole-body motor and cognitive symptoms^(1-5). Dysfunction of the somato-cognitive action network (SCAN)-which is thought to control action execution^(6,7) by coordinating arousal, organ physiology and whole-body motor plans with behavioural motivation-is a potential contributor to the diverse clinical manifestations of PD. To investigate the...

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Biofluid-based biomarkers have transformed neurodegenerative disease research and care, providing insights into the molecular underpinnings of Alzheimer's disease (AD) and other neurodegenerative dementias. This Review provides an update on recent developments in biofluid-based biomarkers for amyloid-β (Aβ) pathology, tau pathology, neurodegeneration, glial reactivity, α-synuclein pathology, TAR DNA-binding protein 43 (TDP-43) pathology, synaptic pathophysiology and cerebrovascular...

Immune checkpoints such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death 1 (PD-1), and programmed cell death ligand 1 (PD-L1) have been targeted in cancer therapy, however, the efficacy of these interventions remains limited. Beyond its immune function on T cell surfaces, CTLA-4 is also expressed in various intrinsic cancer cells, where it influences cell proliferation, metastasis, and apoptosis. The present study aimed to investigate the function of CTLA-4 in...