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Stroke remains the second leading cause of death globally, yet traditional risk factors explain only 50-60 percent of cases. Emerging evidence indicates that lipid dysregulation is a central mechanism linking environmental exposures to cerebrovascular vulnerability. Aging, chronic inflammation, infections, diet, inactivity, stress, sleep disorders, and toxins are associated with disruption of lipid homeostasis through oxidative stress-induced lipid peroxidation, cytokine-mediated metabolic...