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Metasurface quantum graphs for generalized Hong-Ou-Mandel interference
Science, Volume 389, Issue 6758, Page 416-422, July 2025.
De novo design and structure of a peptide–centric TCR mimic binding module
Science, Volume 389, Issue 6758, Page 375-379, July 2025.
Atom-by-atom imaging of moiré phasons with electron ptychography
Science, Volume 389, Issue 6758, Page 423-428, July 2025.
De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells
Science, Volume 389, Issue 6758, Page 380-385, July 2025.
Design of high-specificity binders for peptide–MHC-I complexes
Science, Volume 389, Issue 6758, Page 386-391, July 2025.
Little-to-no industrial fishing occurs in fully and highly protected marine areas
Science, Volume 389, Issue 6758, Page 392-395, July 2025.
Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin
Science, Volume 389, Issue 6758, Page 402-408, July 2025.
Record-breaking 2023 marine heatwaves
Science, Volume 389, Issue 6758, Page 369-374, July 2025.
Global patterns and drivers of untracked industrial fishing in coastal marine protected areas
Science, Volume 389, Issue 6758, Page 396-401, July 2025.
Sensing early civilizations
Science, Volume 389, Issue 6758, Page 356-356, July 2025.
Stone and its stories
Science, Volume 389, Issue 6758, Page 355-355, July 2025.
This trilobite fossil became ancient Roman bling
It’s the first example of this common fossil found in the ancient Roman world
Three ancient human relatives once shared the same valley. Did they meet—and compete?
The world’s greatest concentration of ancestral human remains, in South Africa, poses a 2-million-year-old riddle of coexistence
Fifteen years later, <cite>Science</cite> retracts ‘arsenic life’ paper despite study authors’ protests
Belated decision on widely disputed 2010 study pleases some critics but puzzles and dismays others
Controversial ‘gene-drive’ strategy could make mosquitoes hostile to malaria parasites
New approach aims to reduce disease transmission by quickly spreading a gene variant that occurs naturally in some mosquitoes
Most of Earth’s critical underground fungus is unprotected
First global map of mushrooms that form beneficial relationships with plant roots reveals 90% live outside of conservation areas
IGSF10 is a RET antagonist regulating Ewing sarcoma growth and GnRH neuron migration
RET is a receptor tyrosine kinase that plays important roles in development, cancers, and Parkinson's disease. Here, we identify immunoglobulin superfamily member 10 (IGSF10) as a RET antagonist. We show that Ewing sarcoma depends on IGSF10 and that IGSF10 prevents RET-mediated activation of cdc42, a Rho family G protein and a key regulator of Ewing sarcoma growth as well as cell migration. We demonstrate that IGSF10 binds RET and GAS1, a cell surface RET inhibitor, and assembles an inhibitory...
The evolution of Alzheimer's disease: From mitochondria to microglia
Alzheimer's disease (AD) represents the most prevalent neurodegenerative disorder worldwide. Recent studies highlights that mitochondrial dysfunction drives alterations in microglial function, serving as a pivotal mechanism in the pathogenesis and progression of AD. Increasingly, there is evidence that mitochondrial dysfunction encompasses energy metabolism deficits, heightened oxidative stress, impaired mitochondrial dynamics, disrupted autophagy, and calcium homeostasis imbalances. These...
Micro/nanoplastic-driven cardiovascular senescence and multi-target intervention by traditional Chinese medicine
Micro/nanoplastics (MNPs), pervasive environmental pollutants, accumulate in cardiovascular tissues and drive premature aging through multiscale pathophysiological cascades. This review synthesizes evidence establishing environmental phenotypic aging as a novel mechanistic link between MNP exposure and cardiovascular senescence. MNPs induce mitochondrial damage involving cristae disruption and mtDNA leakage activating cGAS-STING, epigenetic reprogramming encompassing METTL3-mediated m6A...
Choroid plexus-mediated CSF secretion remains stable in aging rats via high and age-resistant metabolic activity
Our brain is bathed in cerebrospinal fluid (CSF) that is produced by the choroid plexus. CSF serves as a dispersion route for hormones and nutrients, and a conduit for waste clearance. Age-dependent reduction in the CSF secretion rate could influence cerebral waste clearance and thereby promote cognitive deficits in the elderly. Here, we resolve age-dependent modulation of CSF dynamics and choroid plexus function by complementary in vivo determinations of intracranial pressure (ICP) and CSF...