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Some scientists opposed the sale on the grounds that it hinders paleontological research

EISCAT_3D will paint a new picture of the upper atmosphere as it is roiled by solar outbursts

Going to the cinema, visiting museums, or attending concerts may do more than entertain. Researchers found that older adults who regularly participated in cultural activities tended to have bodies that functioned like those of people about three years younger. They believe stronger social ties, better mental health, and healthier habits could help explain the link, although more research is needed to determine whether cultural activities directly slow aging.

The Atlantic Ocean’s Balerion Lava Field doesn’t fit any established model of volcanic eruptions

A deadly fungus has wiped out amphibian populations around the globe, yet some mysteriously recover. Researchers discovered that survivors develop powerful immune defenses while they are still tadpoles, giving them a head start before the fungus can attack after metamorphosis. The study also uncovered a vast collection of previously unknown antimicrobial peptides that could someday inspire new drugs to fight infections.

An unusual leopard gecko that naturally develops aggressive tumors may become an important new model for cancer research. Scientists found its tumors share key genetic changes with human cancers, offering a rare opportunity to study the disease as it develops naturally.

“Likweli” find highlights importance of conservation work, researchers say

A new study found that chewing sugary gum after eating nitrate-rich vegetables or drinking beetroot juice helped the body produce more beneficial nitrite, leading to a temporary drop in blood pressure. Researchers hope the discovery will lead to healthier ways to enhance the cardiovascular and performance benefits of dietary nitrate without relying on sugar.

A major review found that people who consumed the most chili peppers had a substantially higher risk of esophageal cancer, though the evidence was less clear for stomach and colorectal cancers. Researchers emphasize that the findings show an association, not proof of cause and effect, and that more research is needed to determine whether moderate consumption carries similar risks.

Inflammasomes, particularly the NLRP3 complex, play a central role in coordinating innate immune activation and neuroinflammatory responses within the cytosol. Persistent or dysregulated nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) activation promotes caspase-1-dependent maturation of interleukin (IL)-1β and IL-18 and triggers gasdermin D (GSDMD)-mediated pyroptosis, thereby contributing to the pathogenic cascades underlying Alzheimer's disease...

This longitudinal study including four independent cohorts assessed the spatiotemporal dynamics of tau extent and load changes in Alzheimer's disease using tau positron emission tomography data from 2,459 participants, including 898 followed for up to 7 years. Regional standardized uptake value ratios indexed tau load, whereas the spatial extent of tauopathy (SEOT) (proportion of abnormal voxels) measured tau extent. We observed burden-dependent longitudinal dynamics of tau progression: SEOT...

Middle age is emerging as a turning point in brain ageing, prognostic of future cognitive health and amenable to intervention. Metabolic and proteomic differences during this period are not yet fully understood and may potentially influence functions of the hippocampus, a brain area that regulates memory and anxiety. While the gut microbiota is implicated in brain ageing, the relationship between the gut microbiota, the metabolic state, and hippocampal proteome in middle age has not been...

Aging and chronic inflammation alter hematopoiesis, impacting the hematopoietic progenitor populations in the bone marrow. In this issue of Immunity, Yao et al. show that the canonical type 2 cytokine interleukin 4 reverses age-related hematopoietic and physiologic effects by rebalancing progenitor fates.

Inflammasomes, particularly the NLRP3 complex, play a central role in coordinating innate immune activation and neuroinflammatory responses within the cytosol. Persistent or dysregulated nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) activation promotes caspase-1-dependent maturation of interleukin (IL)-1β and IL-18 and triggers gasdermin D (GSDMD)-mediated pyroptosis, thereby contributing to the pathogenic cascades underlying Alzheimer's disease...