Aggregator
Daily briefing: Around seven hours of sleep slows biological ageing
Does the PSA test for prostate cancer save lives? New data reverse gold-standard findings
Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis
Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer’s disease pathology
NIH staffing shortage could slash number of new grants issued this year
Procrastination, productivity and inspiration: how research is like designing video games
Mental-health research is too often invisible — it is time to change that
Immune cells in the blood drive brain ageing — blocking them improves memory
Hallucinated citations highest in social sciences preprints site
Are we really headed for a ‘super’ El Niño? What the science says
Author Correction: The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis
Author Correction: Postprandial lipid metabolism durably enhances T cell immunity
Who are the Japanese? Huge DNA discovery rewrites history
Scientists analyzing the genomes of thousands of people across Japan discovered evidence for a previously overlooked third ancestral group, challenging the long-accepted “dual origins” theory. The newly identified ancestry appears linked to the ancient Emishi people of northeastern Japan. Researchers also uncovered inherited Neanderthal and Denisovan DNA connected to conditions like diabetes, heart disease, and cancer.
In unreleased document, fired U.S. science board issues stark warning about keeping pace with China
The National Science Board urges robust response to China’s rise in cover letter to its biennial report on the global research enterprise
Did this scientist go too far trying to save Ecuador’s wildlife?
Alejandro Arteaga’s efforts to identify and protect tropical reptiles and amphibians have entangled him in controversy
New psychedelic-like drugs could treat depression without making you trip
UC Davis researchers created brand-new psychedelic-like compounds by shining UV light on amino acid-based molecules. These compounds activated key serotonin receptors tied to brain plasticity and mental health benefits, but surprisingly did not cause hallucination-like behavior in animal tests. Scientists say the discovery could lead to future treatments for depression, PTSD, and addiction without the intense psychedelic experience.
Ghost of long-extinct ancestor lives on in people today
Ancient Homo erectus teeth from China yield protein variants seen in Denisovans—and us
Fluffy ice could imperil spacecraft landings on ocean moons
Water erupted from cryovolcanoes may freeze into thick but fragile layers on Europa and Enceladus
Secreted GPNMB enhances uptake of fibrillar alpha-synuclein in a non-cell-autonomous process that can be blocked by anti-GPNMB antibodies
Glycoprotein nonmetastatic melanoma B (GPNMB) is critical to cellular uptake of pathological forms of alpha-synuclein (aSyn), the hallmark disease protein in Parkinson's disease (PD). Here, we demonstrate that the non-membrane-anchored, extracellular domain of GPNMB can function in a non-cell-autonomous manner. In the human brain, GPNMB is widely expressed in neurons and microglia. In induced pluripotent stem cell-derived microglia (iMicroglia), GPNMB expression and secretion increase with...
A human Staufen1 BAC transgenic mouse exhibits abnormal autophagy and neurodegeneration across the central nervous system
RNA-binding proteins (RBPs) play an essential role in development, normal functioning, and human disease. Staufen1 (STAU1) is an RBP that regulates mRNA degradation and subcellular localization, and is part of the ATXN2 protein complex. Previously, we showed that STAU1 is overabundant in patient fibroblasts and in mouse models of Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and spinocerebellar ataxia type 2 (SCA2), where it is associated with impaired autophagic flux due to...