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CONCLUSION: Digital technologies provide a limited but meaningful contribution to sustaining social cohesion among older adults in rural, conflict-affected Myanmar by supporting communication, emotional connection, and access to information. However, their contribution remains uneven, as structural inequalities, political constraints, and infrastructural limitations continue to restrict equitable access. Addressing these challenges requires context-sensitive, age-appropriate digital inclusion...

Autophagy constitutes a major adaptive response that preserves cellular and organismal homeostasis during stress. However, stress responses also engage systemic communication pathways that may either maintain resilience or propagate pathology. We previously identified acyl-CoA-binding protein, also known as diazepam-binding inhibitor (DBI/ACBP), as a phylogenetically conserved extracellular factor secreted by stressed cells through an unconventional autophagy-dependent pathway. Once released,...

The Endless Frontier traces the lives of three scientists as they train students and deal with funding pressures

Just 90–120 minutes of strength training a week may deliver some of the biggest long-term health rewards, according to a study tracking more than 147,000 people for 30 years. That amount was linked to lower risks of death overall, particularly from cardiovascular and neurological diseases. Combining strength workouts with aerobic exercise produced even stronger benefits.

Group offers new scenario for how cells came to rely on phosphate molecules to build DNA and store energy

A potentially dangerous tapeworm linked to severe, cancer-like disease has now been found in the Pacific Northwest, marking its first detection in wild animals along the U.S. West Coast. Researchers discovered the parasite, Echinococcus multilocularis, in 37% of coyotes tested around Puget Sound—a surprisingly high rate for a region where it had never been reported until recently.

New guidelines aim to help scientists verify, communicate, and manage evidence of extraterrestrial intelligence

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Adult stem cells are essential for maintaining tissue homeostasis and facilitating tissue repair. The ability of aged stem cells to generate functional progeny declines, which is closely associated with the onset and progression of age-related diseases. The aging of adult stem cells in various tissues is regulated jointly by local microenvironments (stem cell niches) and systemic factors. Caloric restriction (CR), a widely studied anti-aging strategy, has been demonstrated to rejuvenate aged...

Cellular senescence plays a critical role in diabetic nephropathy (DN). Understanding the mechanisms underlying the senescence response is therefore essential for developing effective therapies for DN. In this study, we provide evidence that NAT10 expression was markedly elevated in the kidney tissues of patient with DN and was associated with adverse clinical outcomes. NAT10 directly bound to PAPP-A, induced ac4C acetylation modification of the PAPP-A transcript, and enhanced its stability,...

Advances in proteomics are transforming our understanding of mammalian oocyte maturation and preimplantation embryo development. These resources and their findings provide unprecedented insights into the molecular underpinnings of developmental competence. Here we summarize the ongoing development of proteomic methodologies and highlight the stage-specific reprogramming events of the proteome in both humans and mice, underscoring the unique utility of proteomics in deciphering oocyte maturation...