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AI-redesigned starting points and outcomes enhance protein evolution
Precise DNA base editing using AlphaFold3-based contact modelling
A vector-based strategy for olfactory navigation in <i>Drosophila</i>
Tertiary lymphoid structures harbour stem-like tumour-specific T cells
Planetary-mass exosatellite detected around the substellar companion of a star
Insulator-free topological photonic multi-lane highways
Structural basis of the RNA-editing cascade in trypanosome mitochondria
Prior therapy defines mutation profiles in childhood cancer at relapse
Non-epitaxial perovskite polariton laser diode operating under direct current
CRISPR–Cas regulates expression of embedded anti-phage defence systems
Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase
How do quantum computers work?
What counts as a moon? Huge ‘exosatellite’ sparks debate
RNA synthesis and substrate analog inhibition in the CCHFV polymerase
Electronic-resonance enhanced molecule for perovskite solar cells
Polio should have been eradicated by now. What’s plan B?
White House report calls for big changes to ‘calcified’ U.S. science system
In Congress today, Trump science adviser Michael Kratsios faced critics of the proposals
New cancer strategy could stop tumors before resistance takes hold
Researchers are applying evolutionary theory to cancer by changing treatments before tumors have time to develop resistance. Mathematical models suggest that rapid, carefully timed switches between multiple therapies could improve cure rates.
Magic mushrooms may reshape the brain long after the trip ends
A single dose of psilocybin produced measurable changes in brain activity and possible changes in brain structure that lasted for up to a month. Participants who experienced the greatest increase in flexible, varied brain activity also reported more personal insight and later improvements in well-being. The findings suggest that the psychedelic experience itself may help people break free from entrenched patterns of thinking.
Coffee may protect your heart but energy drinks could harm it
For most adults, a daily caffeine habit may be safer for the heart than many people assume. A new American Heart Association review found that up to 400 milligrams of caffeine a day, roughly three to five cups of regular black coffee, is generally safe and may even be linked to lower risks of heart disease, stroke, heart failure, and Type 2 diabetes. But the source matters: highly concentrated energy drinks and shots can sharply raise blood pressure and trigger irregular heart rhythms.