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Brain aging is increasingly recognized as a heterogeneous and systems-level process involving dynamic interactions among neuronal, glial, vascular, and immune-associated cell populations. Recent advances in single-cell and spatial omics technologies have revealed diverse cellular aging trajectories, region-specific vulnerabilities, and extensive remodeling of intercellular communication networks across the aging brain. These findings challenge reductionist views of aging and emphasize the...

[This corrects the article DOI: 10.3389/fnagi.2026.1707228.].

The aging bone marrow microenvironment is characterized by chronic low-grade inflammation ("inflammaging"), which disrupts skeletal homeostasis and impairs bone regeneration. However, the stromal-immune crosstalk mechanisms sustaining this pathological state remain poorly defined. Here, transcriptomic analysis identified thrombospondin-1 (Thbs1) as a key upregulated component of the senescence-associated secretory phenotype (SASP) in aged bone mesenchymal stromal cells (BMSCs). We demonstrate...

Kaempferol (KMP) is a dietary compound found in a wide range of foods. The therapeutic capabilities of these foods are associated with the phenolic compounds present in their structures, particularly their antioxidant activity. Remarkable medical care areas linked to KMP include pain relief, anti-aging, antiallergic, anticancer, antidiabetic, anti-inflammatory, antioxidant, antipyretic, central nervous system regulation, wound healing, and hepatoprotective characteristics. KMP has attracted...

Age-related decline in speech perception is a prominent challenge in auditory aging, especially under noise conditions. However, how neural and neurovascular processes are jointly organized and coordinated across adulthood during speech perception remains incompletely characterized. This study employed simultaneous electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) to investigate neural activation, functional connectivity, and neurovascular coupling across youth (n =...

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A critical developmental process affecting aging and age-associated disease, cell senescence is characterized by persistent growth arrest and adaptive gene expression patterns. A common RNA modification, N6-methyladenosine (m⁶A), regulates gene expression profiles but its impact on senescence has not been studied globally. Here, we elucidated the m⁶A landscape in proliferating and senescent human fibroblasts using epitranscriptomic microarray and m⁶A-crosslinking and immunoprecipitation followed...

Agency is bringing back a version of a funding limit that was quickly abandoned nearly a decade ago

Facing economic and regulatory pressures, Inotiv says it is seeking ways to continue operations