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From matrix to nucleus: CD44 as a central regulator of inflammaging, autophagy, and tissue homeostasis
Aging is characterized by a progressive decline in cellular and tissue function, shaped in part by disruptions in communication between the extracellular matrix (ECM) and intracellular signaling networks. The cell surface receptor CD44 functions as a molecular hub, integrating signals from a remodeled ECM to regulate core aging programs including senescence, inflammation, and metabolic balance. This review synthesizes evidence that CD44, through its structural domains, isoform diversity, and...
A machine learning approach to identify key epigenetic transcripts for ageing research in human blood (Epitage)
DNA methylation is an established biomarker of human ageing and is used by a variety of tools to identify meaningful epigenetic signals. We investigated whether analysing CpGs grouped by transcript as functional units could generate a ranked list of transcripts most correlated with age that might otherwise be overlooked in genome-wide CpG-based studies. Here we present Epitage ( https://github.com/a00s/epitage ), a continuously updated ranked list of transcripts built from the GSE87571 dataset...
Scientists revive a powerful antibiotic that superbugs had defeated
Scientists have found a way to revive vancomycin, a powerful antibiotic that some dangerous bacteria have learned to resist. Instead of creating an entirely new drug, researchers paired vancomycin with a small molecule called pghi-4, which blocks a bacterial enzyme linked to resistance. The combination restored the antibiotic’s ability to kill drug-resistant E. faecium, raising hopes that similar chemical helpers could rescue other failing medicines.