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Neurodegenerative diseases (NDs) are chronic neurological diseases characterized by progressive neuronal loss and pathological protein deposition in specific brain regions. With the deepening of population aging, these diseases have become one of the most serious public health challenges. Due to the high heterogeneity of these disorders and the complex pathogenesis, it brings great challenges to clinical precision diagnosis and treatment. In this context, nuclear medicine molecular imaging...

Handgrip strength asymmetry (HGSA) and low handgrip strength (LHGS) reflect distinct aspects of muscle health, but their changes over time have been less studied. We examined whether two-wave status patterns of HGSA and LHGS were associated with all-cause mortality in middle-aged and older Chinese adults. We analyzed 8924 participants aged ≥ 45 years from the China Health and Retirement Longitudinal Study. HGSA and LHGS were assessed in 2011 and 2013 and classified as normal at both waves, newly...

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CONCLUSIONS: In this population-based cohort study, participation in a low-intensity preventive health program delivered in routine care was associated with a lower incidence of diabetes among older adults. However, the observational study design limits evidence on the intervention's role in the observed association, and more robust evidence is needed. Nevertheless, these findings suggest that scalable, population-wide prevention strategies may complement intensive high-risk approaches in...

ObjectivesThis study examines how early-life hardship, wartime exposure, military service, and adult socioeconomic position are associated with grip strength-based possible sarcopenia among older adults in postwar Vietnam.MethodsWe analyzed data from the Wave 1 Vietnam Health and Aging Study among 2,166 adults aged 59 and older. Possible sarcopenia was defined using Asian Working Group for Sarcopenia 2019 grip-strength thresholds; survey-adjusted logistic regression models were...

CONCLUSIONS: Elevated and persistent BNP abnormalities are consistently associated with IC decline, supporting BNP as a practical biomarker for early identification of older adults at risk of functional deterioration.

Budget chief Russell Vought reportedly wants more power to veto DEI-related funding

A sweeping review of more than 153,000 adults found that calcium and vitamin D supplements, alone or together, do little to prevent fractures or falls in most older people. Researchers say the findings challenge routine supplementation for prevention and point instead toward strategies such as balance and resistance exercise.

Common preservatives hiding in processed foods may carry unexpected heart risks, with heavy consumption linked to substantially higher rates of high blood pressure and cardiovascular disease. Researchers identified eight widely used preservatives associated with hypertension, although the observational study cannot prove they were directly responsible.