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Science, Volume 391, Issue 6784, Page 494-498, January 2026.

Science, Volume 391, Issue 6784, Page 511-516, January 2026.

Science, Volume 391, Issue 6784, Page 504-510, January 2026.

Science, Volume 391, Issue 6784, Page 476-479, January 2026.

Science, Volume 391, Issue 6784, Page 480-484, January 2026.

Science, Volume 391, Issue 6784, Page 517-521, January 2026.

Science, Volume 391, Issue 6784, Page 485-488, January 2026.

Science, Volume 391, Issue 6784, Page 499-503, January 2026.

Science, Volume 391, Issue 6784, Page 454-454, January 2026.

Science, Volume 391, Issue 6784, Page 453-453, January 2026.

Research council to slash funding for particle physics, nuclear physics, and astronomy by 30%, prompting alarm across the research community

Shields and biological countermeasures could help protect astronauts during prolonged missions beyond Earth's magnetic bubble

Long-overlooked Kepler signal discovered by citizen scientists reveals promising world worth a closer look

Blood-brain barrier (BBB) dysfunction is a hallmark of many diseases of the brain, including those that represent the largest healthcare burden (for example, Alzheimer disease and stroke). Despite this, rejuvenation and repair of the BBB is not a mainstream concept. During life, the BBB is subjected to perturbations and stresses from a wide range of endogenous or exogenous sources, which can promote brain health or can lead to brain pathologies. The BBB supports many functions that are critical...

Emerging evidence suggests that Parkinson's disease (PD) may have its origin in the enteric nervous system (ENS), from where α-synuclein (αS) pathology spreads to the brain^(1-4). Decades before the onset of motor symptoms, patients with PD suffer from constipation and present with circulating T cells responsive to αS, suggesting that peripheral immune responses initiated in the ENS may be involved in the early stages of PD^(1,5-7). However, cellular mechanisms that trigger αS pathology in the...

Blood-brain barrier (BBB) dysfunction is a hallmark of many diseases of the brain, including those that represent the largest healthcare burden (for example, Alzheimer disease and stroke). Despite this, rejuvenation and repair of the BBB is not a mainstream concept. During life, the BBB is subjected to perturbations and stresses from a wide range of endogenous or exogenous sources, which can promote brain health or can lead to brain pathologies. The BBB supports many functions that are critical...

No abstract

Spatiotemporal changes in the nuclear lamina and cell metabolism shape cell fate, yet their interplay is poorly understood. Here we identify lamin A/C as a key regulator of cysteine catabolic flux essential for proper cell fate and longevity. Its loss in naive mouse pluripotent stem cells leads to upregulation of the cysteine-generating and catabolizing enzymes, cystathionine γ-lyase (CTH) and cystathionine β-synthase (CBS), thereby promoting de novo cysteine synthesis. Increased cysteine flux...

Integrated circuits for communications play an enabling role when it comes to outer-space exploration thanks to their small footprint and low weight^(1-3). However, owing to the severe irradiation effects of space energetic particles, the implementation of radiation-tolerant electronic circuits remains a challenge^(4-6). Here we report the observation of the space radiation effect on a satellite-based device and find that atomically thin materials are expected to accumulate minimal...

CONCLUSION: This claims-based frailty prediction model showed reasonable performance and prognostic value. It may support efficient, population-level frailty screenings where questionnaire-based assessments are impractical.