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Impaired MAPT/tau-secretory lysosomes are linked to cognitive vulnerability in Alzheimer patients

6 months 3 weeks ago
MAPT/tau proteins propagate between brain regions in a prion-like manner, driving the onset and progression of dementia in Alzheimer disease (AD). However, the basis for variability in dementia progression among AD patients remains poorly understood. Here, we demonstrate that cognitively resilient AD patients, characterized by reduced MAPT/tau pathology, maintain lysosomal integrity, whereas cognitively vulnerable patients, exhibiting greater MAPT/tau burden, display lysosomal dysfunction....
Preeti Sharma

The house mouse maintains constant telomere length throughout life

6 months 3 weeks ago
Telomeres protect the chromosome ends from deleterious DNA damage response and repair activities. In humans, telomerase maintains telomere length in germ and stem cells, but not in most somatic cells. Consequently, telomeres shorten with cell division and age, limiting cell proliferation and protecting against cancer. When telomeres become critically short, they may also cause senescence, inflammation, and organ failure, which are major drivers of aging. Therefore, maintaining an optimal,...
Riham Smoom

Late-Life Aerobic Exercise Attenuates DNA Damage and Telomere Dysfunction in Non-Atheroprone but Not in Atheroprone Aortic Regions

6 months 3 weeks ago
Cellular senescence is a state of persistent cell cycle arrest and is a critical contributor to arterial aging. The primary drivers of cellular senescence are the DNA damage response (DDR) and telomere dysfunction, which is induced by increasing exposure to DNA-damaging stimuli such as atheroprone shear stress. While late-life aerobic exercise is an effective intervention to mitigate arterial aging, its specific impact on the DDR and telomere dysfunction is unknown and may not show uniform...
Jisok Lim

Septal LYVE1+ macrophages control adipocyte stem cell adipogenic potential

6 months 3 weeks ago
Science, Volume 389, Issue 6763, August 2025.
Xiaotong Yu, Yanan Hu, Hwee Ying Lim, Ziyi Li, Diego Adhemar Jaitin, Katharine Yang, Wan Ting Kong, Jiaqian Xu, David Alejandro Bejarano, Mathilde Bied, Lucie Orliaguet, Gowshika Rengasamy, Zachary Chow, Christopher Zhe Wei Lee, Josephine Lum, Jing Tian,…

Somatotopic organization of brainstem analgesic circuitry

6 months 3 weeks ago
Science, Volume 389, Issue 6763, August 2025.
Lewis S. Crawford, Fernando A. Tinoco Mendoza, Rebecca V. Robertson, Noemi Meylakh, Paul M. Macey, Kirsty Bannister, Tor D. Wager, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson

Machine learning–based penetrance of genetic variants

6 months 3 weeks ago
Science, Volume 389, Issue 6763, August 2025.
Iain S. Forrest, Ha My T. Vy, Ghislain Rocheleau, Daniel M. Jordan, Ben O. Petrazzini, Girish N. Nadkarni, Judy H. Cho, Mythily Ganapathi, Kuan-Lin Huang, Wendy K. Chung, Ron Do

In Science Journals

6 months 3 weeks ago
Science, Volume 389, Issue 6763, Page 890-892, August 2025.
Michael Funk, and Angela Hessler, Bianca Lopez, Michael A. Funk, Marc S. Lavine, Ian S. Osborne, Vadim Cherezov, Jack Huang, Annalisa VanHook, Jesse Smith, Mattia Maroso, Yevgeniya Nusinovich, Stella M. Hurtley, Sarah H. Ross, Sacha Vignieri, Christiana…