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Daily briefing: The battle over the identity of the first animals
Still working at 107: supercentenarian study probes genetics of extreme longevity
Sensors are transforming the world — work together to maximize their benefits
Author Correction: Nutrient-sensing nuclear receptors coordinate autophagy
Author Correction: Relatively warm deep-water formation persisted in the Last Glacial Maximum
Should professors be forced to retire?
How to eat well and within Earth’s limits
What were the first animals? The fierce sponge–jelly battle that just won’t end
African science needs to cut reliance on foreign donors
Spotting viral invaders in koala family trees
Street-dog policy in India is barking up the wrong tree
Social-media bans: why corporate fines could backfire
Volcanic personality: the man who recognized volcanoes as a planet-shaping force of nature
Fluttering ‘tails’ on bird nests confuse would-be predators
Blue manakins in Brazil use “disruptive camouflage” to protect their eggs, new study finds
Splat! Could roadkill replace some studies of live animals?
Science chats with an ecologist about the advantages of using discarded carcasses for research
Congress set to cut basic defense science funding
But lawmakers reject Trump’s call for deeper downsizing and boost applied and medical research
Daily briefing: Why cancer might protect against Alzheimer's disease
No abstract
Discovery of NIRF theranostic probes targeting amyloid-beta and cholinesterases in Alzheimer's disease models
Alzheimer's disease (AD) remains a major unmet medical challenge, with limited tools that integrate early diagnosis and therapeutic intervention. Considering the pivotal roles of amyloid-β (Aβ) and cholinesterases (ChEs) in AD etiology, we report dual-functional theranostic NIR-I probes. The lead candidate, I-43, exhibits favorable NIR optical properties (Stokes shift ≥ 220 nm) and binds strongly to Aβ fibrils, with K(d) values of 58.2 ± 9.7 nM for Aβ(1-40) and 104 ± 25 nM for Aβ(1-42)....
Falls as a Predictor of Future Dementia in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis
CONCLUSIONS AND IMPLICATIONS: This study demonstrates that multiple falls are a significant predictor of future dementia and highlights the importance of fall frequency. Recurrent falls may serve as a potential clinical marker for identifying individuals at higher risk. Clinicians should maintain heightened vigilance for cognitive decline in middle-aged and older adults with a history of recurrent falls to facilitate early detection of dementia. Given the limited evidence base and high...
The role of social context in cognitive and neurobehavioural outcomes in epilepsy
Cognitive and psychiatric comorbidities are among the most persistent and disabling challenges experienced by children and adults with epilepsy, with serious implications for daily functioning, health-care utilization, long-term social outcomes and quality of life. Traditionally, research has focused on epilepsy-specific biological risk factors, such as seizure frequency or epilepsy syndrome, but growing evidence indicates that non-medical factors also shape neurodevelopmental, cognitive and...