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INTRODUCTION: Age-related decline in visual processing has been observed in association with reduced orientation selectivity and decreased signal-to-noise ratios in the primary visual cortex (V1). Elevated noise correlations between neurons are associated with impaired visual discrimination in aging; however, less is known about therapeutic interventions that could preserve visual cortical function during aging. In this study, we investigated the effects of metformin treatment on age-related...

Aging is a multifactorial process driven by accumulating cellular damage. Ferroptosis-an iron-dependent, lipid peroxidation-mediated form of cell death-has emerged as a critical contributor to age-related tissue degeneration. This review synthesizes current evidence linking ferroptosis to key aging hallmarks, including oxidative stress, chronic inflammation, mitochondrial dysfunction, and dysregulated iron metabolism. Central to these interactions is the age-associated decline in antioxidant...

Phalanx of instruments scrutinize 3I/ATLAS for clues about planet formation elsewhere in the galaxy

Trump executive order leads to pauses on U.S.-funded research into TB, influenza, COVID-19, and other diseases, dismaying some scientists

Cracking the main subtype of the Dhofari script could reveal “an entirely new page of the history of Arabia”

House spending committee has taken similar position on 2026 request

Synaptic loss strongly correlates with cognitive impairment in Alzheimer's disease (AD), yet the mechanism linking its origin and pattern remain unclear. Given that connected brain regions share molecular and synaptic features, and pathological tau, a key driver of synaptic degeneration, propagates through brain networks, we hypothesize that network architecture may influence synaptic loss in AD. By combining synaptic vesicle glycoprotein 2 A (SV2A) PET in 91 AD patients and 54 controls with...

CONCLUSIONS AND IMPLICATIONS: Caregivers' decisions to retire from the labor force were mostly driven by their care recipients' care needs. These findings may suggest the need for flexible workplace policies that accommodate varied caregiving responsibilities to support caregivers. Increasing access to congregate residential and respite care may be another strategy that could reduce caregiver burden and retirement from the labor force.

Ovarian aging is a critical yet understudied driver of systemic aging in female bodies, with profound implications for female health and longevity. Despite its significance, we still know little about ovarian aging and its systemic effects on aging trajectories. With new efforts over the past few years, interest in the field has been growing and there is momentum to address these questions. This review highlights the importance of leveraging modern tools and approaches to better understand...

Memory T cells are a highly heterogeneous collection of antigen-experienced cells that undergo dynamic adaptations upon antigen re-encounter and environmental signals. This heterogeneity hinders studies on memory T cell durability and age-related dysfunction. Using chronic Epstein-Barr virus (EBV) infection and barcode-enabled antigen tracing, we assess the influence of age on memory states at the level of single antigen-specific CD8^(+) T cells. In young adults (<40 years), EBV-specific CD8^(+)...

Connections between the nervous and immune systems are increasingly recognized as central to brain-body physiology. In this Review, we examine how these systems collaborate to detect and respond to both internal and external stimuli - such as psychological stress, circadian cues, infection, and tissue injury. Rather than operating in isolation, the nervous and immune systems form an integrated network that is more than the sum of its parts. They share a common architecture and vocabulary,...

DNA is a promising medium for digital data storage due to its exceptional data density and longevity. Practical DNA-based storage systems require selective data retrieval to minimize decoding time and costs. In this work, we introduce CRISPR-Cas9 as a user-friendly tool for multiplexed, low-latency molecular data extraction. We first present a one-pot, multiplexed random access method in which specific data files are selectively cleaved using a CRISPR-Cas9 addressing system and then sequenced...

Cellular senescence represents a permanent state of cell cycle arrest, also observed in neurodegenerative disorders. As p300 has been identified as an epigenetic driver of replicative senescence, we aimed to investigate whether in vitro p300 inhibition could rescue the stress-induced premature senescence (SIPS) phenotype. We exploited 2D and 3D (brain organoids) in vitro models of SIPS using two different stressor agents. In addition, we combined the treatment with a p300 inhibitor and validated...