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Proposal would end nearly all new major science missions

Halt to foreign “subawards” disrupts ongoing global studies and has researchers scrambling to fulfill ethical obligations to trial volunteers

References to phantom studies comes after White House pledge to practice “gold standard” science

New system yields sharp views of the Sun’s mysterious outer atmosphere

Free Water (FW) is considered an indicator of neuroinflammation, while the Index of Diffusivity along the Perivascular Space (ALPS) is a recently introduced measure of glymphatic function. However, no study has yet investigated the specific relationships between these factors simultaneously. This study aimed to examine changes in FW in the thalamic midline and lateral nuclei in Parkinson's disease (PD), with a particular focus on the potential influence of glymphatic system dysfunction. MRI data...

Type 2 diabetes (T2D) is a significant risk factor for Alzheimer's disease (AD). Despite multiple studies reporting this connection, the mechanism by which T2D exacerbates AD is poorly understood. It is challenging to design studies that address co-occurring and comorbid diseases, limiting the number of existing evidence bases. To address this challenge, we expanded the applications of a computational framework called Translatable Components Regression (TransComp-R), initially designed for...

The mechanistic target of rapamycin (mTOR) serves as an essential hub in sensing metabolic stress and regulating aging, although the differential contributions of mTOR-regulated protein and cholesterol synthesis are unclear. Post-transcriptional modifications of mRNAs, such as N6-methyladenosine (m6A), occur rapidly in response to acute environmental changes to maintain tissue homeostasis. Here, we showed that loss of YTH m6A RNA-binding protein 1 (YTHDF1) accelerated murine aging....

With the continuous development of high-performance copper alloys in modern industries, it becomes increasingly challenging to further enhance their conductivities. The key bottleneck is the existence of an upper limit on the amount of precipitation, leading to inadequate purification of the copper matrix. Here we demonstrate a phenomenon of significant conductivity enhancement in a Cu-Be alloy through undercooling. It shows that lots of spherical Be-rich clusters can spontaneously form in the...

Despite the manifestation and contribution of cellular senescence to aging and various diseases, accurate identification of heterogeneous senescent cells remains challenging. Current senescence evaluation methods rely mainly on limited markers or homogeneous samples, which might fail to capture universal senescence features, limiting their generalizability. Here we developed the human universal senescence index (hUSI), an accurate and robust senescence evaluation method for diverse cells and...

Human longevity, which is coupled to compression of age-related disease, is a heritable trait. However, only few common genetic variants have been linked to longevity, suggesting that rare, family-specific variants may also play a role. We therefore investigated whole-genome sequencing data of long-lived individuals from the Leiden Longevity Study and identified family-specific variants residing in genes involved in the mitogen-activated protein kinase (MAPK) cascade, a lifespan-associated and...

CONCLUSIONS: This large-scale prospective study found that MCR significantly predicts falls in older adults, highlighting its potential as a clinically useful screening tool integrating cognitive and motor parameters for improved fall risk identification.

CONCLUSION: The global burden of AHL continues to rise, which is a growing problem for countries with medium SDI levels. Occupational noise exposure emerges as a critical modifiable risk factor, particularly in rapidly industrializing economies, highlighting the urgent need to prioritize workplace hearing protection programs and targeted noise control policies tailored to regional contexts. These interventions are especially vital for older men in low-resource settings and medically underserved...

CONCLUSIONS: Insomnia and longer sleep duration are negative factors for SA in Chinese older adults, and good sleep quality indicated by no insomnia seems more important than sleep duration for SA.

CONCLUSIONS: The life story group intervention significantly improved older adults' attitudes toward aging, supporting its use as a psychosocial intervention. Encouraging participation in narrative-based interventions may promote active engagement, self-identity, and resilience.

The abnormal accumulation of α-synuclein (α-Syn) is a key feature of Parkinson's disease (PD) and other synucleinopathies. α-Syn undergoes liquid-liquid phase separation (LLPS) to accelerate the amyloid aggregation. β-synuclein (β-Syn) colocalizes with α-Syn and affects its aggregation. It remains poorly understood how the LLPS of α-Syn is regulated by β-Syn. Here, we find that β-Syn co-condenses with α-Syn, negatively regulating the LLPS of α-Syn. The mobility of α-Syn is reduced in α-Syn/β-Syn...

With all the advances in both the science of aging and artificial intelligence (AI), we are in a propitious position to accurately and precisely determine who is at high risk of developing Alzheimer's disease years before signs of even mild cognitive deficit. It takes at least 20 years for aggregates of misfolded β-amyloid and tau proteins to accumulate in the brain along with neuroinflammation that they incite. This provides a long window of opportunity to get ahead of the pathobiological...

Degeneration of the auditory and vestibular hair cells (HCs) leads to dysfunction of two essential senses: hearing loss and decompensated balance perception. However, the cellular and molecular mechanisms governing inner ear aging and its link to dysfunctions of sensory HCs remain unclear. Here, we constructed an aging-associated cell atlas of cochlear and utricular tissues in C57BL/6J mice through single-nucleus RNA sequencing, revealing transcriptionally distinct hair cell subtypes and...

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There is a path to living longer and healthier that doesn't require reversing the aging process.