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A chronic low dose of Δ<sup>9</sup>-tetrahydrocannabinol (3 mg / kg / 21 d) reorganizes the disturbed wound healing process and accelerates wound closure in old female mice

6 months 3 weeks ago
Wound healing in old mice is characterized by disturbed tissue homeostasis, manifested by delayed immune cell infiltration and reduced growth factor secretion, leading to a delayed onset and prolonged duration of the inflammatory phase. The endocannabinoid system (ECS) is an important regulator of tissue homeostasis and cell migration and is also considered to be subject to aging processes, which may contribute to observable aging phenomena. Therefore, stimulating the aged ECS could represent a...
Melissa Plum

Low hand grip strength is associated with increased risk of cognitive impairment in older men, including men with probable sarcopenic obesity: results from the Northern Ireland PRIME-COG cohort

6 months 3 weeks ago
CONCLUSIONS: Probable sarcopenia, indicated by low HGS, was associated with an increased risk of cognitive impairment in older men, with risk consistent across BMI strata, including men living with probable sarcopenic obesity. Our findings have clinical relevance, suggesting that phenotypes comprising low muscle strength, in the presence of excess adiposity must not be overlooked and appropriate interventions explored to attenuate physical perturbations which could carry significance towards...
Dominic N Farsi