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CONCLUSIONS: Regular use of glucosamine was associated with a reduced risk of several age-related chronic diseases. Further studies are needed to confirm these findings and to clarify its potential role in supporting healthy aging.

Although cognitive changes may not become apparent until after age 65, many factors associated with late-life decline are already well-established in midlife. In particular, deficits in picture naming have been associated with early and accelerated cognitive change. A measure of picture vocabulary, requiring participants to name drawings of objects, was collected in 4 waves (each separated by 2 years) of the Understanding America Study, a nationally representative internet panel (mean follow-up...

Advice follows Supreme Court ruling that threatened previously restored grants, but reprieve may be brief

Series of droughts chronicled in cave rocks likely pushed civilization to breaking point

New U.S.-Brazil study points to ways of countering election misinformation, political scientists say

If confirmed, vast cloud could test predictions about the Milky Way’s hidden architecture

Funders test algorithms to spot promising science, raising hopes of faster reviews—and fears of bias

The unusually tiny particles of hexavalent chromium could pose a health hazard despite low levels, researchers say

Amyloid β (Aβ)-dependent circuit dysfunction in Alzheimer's disease (AD) is determined by a puzzling mix of hyperactive and inactive ("silent") brain neurons. Recent studies identified excessive glutamate accumulation as a key Aβ-dependent determinant of hyperactivity. The cellular mechanisms underlying neuronal silence depend on both Aβ and tau protein pathologies, with an unknown role of Aβ. Here, by using single-cell-initiated rabies virus (RV) tracing in mouse models of β-amyloidosis, we...