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Mitochondrial origins of the pressure to sleep
Super-resolution stimulated X-ray Raman spectroscopy
Neutrophils drive vascular occlusion, tumour necrosis and metastasis
Immigrant–native pay gap driven by lack of access to high-paying jobs
A male-essential miRNA is key for avian sex chromosome dosage compensation
Imidazole propionate is a driver and therapeutic target in atherosclerosis
Redox-powered autonomous directional C–C bond rotation under enzyme control
‘Stealth flippers’ helped this extinct mega-predator stalk its prey
Author Correction: BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans
Temperature-Related Hospitalization Burden under Climate Change
The breakthrough proof bringing mathematics closer to a grand unified theory
New transplant techniques keep organ donors’ hearts healthy—even after they stop beating
Strategies for preserving the heart after circulation stops could avoid ethical concerns and enable more transplants
‘Lazy’ authors? One in six scientific papers mischaracterize work they cite
New study of long-standing problem takes novel approach, asking cited authors to evaluate accuracy
A mushroom that escaped from kitchens could be harming North American wildlife
The golden oyster mushroom has gone rogue, displacing native fungi that live in dead trees
Majority of fruit fly immunity studies can be replicated, huge analysis finds
Verification of 50 years of data bolsters immunology research, but identifies “suspicious” papers that don’t hold up
Ancient human ancestor emerges from sunken Southeast Asian landmass
Submerged fossils are revealing long-held secrets from a region known as Sundaland
A genetically encoded selection for amyloid-β oligomer binders
Soluble amyloid-β oligomers (AβOs) are a hypothesized source of neurotoxicity in Alzheimer disease. Binding proteins that recognize these species may have high utility in diagnostic and therapeutic applications. However, identifying binders to AβOs directly generated from the aggregation cascade is challenging because of the short lifetime and low concentrations of oligomer populations. We report a strategy to detect binding to AβOs formed during Aβ42 aggregation using a genetically encoded...
Smart brain-zapping implants could revolutionize Parkinson's treatment
No abstract
Global collaboration is key to decoding Alzheimer's disease
No abstract
The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging
More than 57 million people globally suffer from neurodegenerative diseases, a figure expected to double every 20 years. Despite this growing burden, there are currently no cures, and treatment options remain limited due to disease heterogeneity, prolonged preclinical and prodromal phases, poor understanding of disease mechanisms, and diagnostic challenges. Identifying novel biomarkers is crucial for improving early detection, prognosis, staging and subtyping of these conditions....