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The Effect of Advancing Age and Intraocular Pressure Injury on Retinal Ganglion Cell Function and Synaptic Connectivity

6 months 2 weeks ago
Age and elevated intraocular pressure (IOP) are the two major risk factors for developing glaucoma, a leading cause of blindness worldwide that is characterized by the loss of retinal ganglion cells (RGCs). Although vision loss is irreversible over the long term, accumulating evidence points to short-term improvement of vision in glaucoma patients in response to certain interventions, suggesting that RGCs have the capacity to recover function. In the present study, we sought to investigate the...
Vicki Chrysostomou

Organizational Work, Well-Being, and Quality of Life at an Elderly Age: The Case of Cyprus

6 months 2 weeks ago
This study investigates the impact of postretirement organizational work on the well-being and overall quality of life of the elderly population in Cyprus. Specifically, it evaluates the multifaceted effects of continued employment after retirement, based on data collected through a survey administered to a representative sample of elderly Cypriots. The research findings, informed by prominent instruments in the field, demonstrate significant enhancements in autonomy, self-actualization, and...
George Papageorgiou

BACE1-dependent cleavage of GABA(A) receptor contributes to neural hyperexcitability and disease progression in Alzheimer's disease

6 months 2 weeks ago
Neural hyperexcitability has been clinically associated with amyloid-β (Aβ) pathology and cognitive impairment in Alzheimer's disease (AD). Here, we show that decreased GABA(A) receptor (GABA(A)R) currents are linked to hippocampal granule cell hyperexcitability in the AD mouse model APP23. Elevated levels of β-secretase (BACE1), the β-secretase responsible for generating Aβ peptides, lead to aberrant cleavage of GABA(A)R β1/2/3 subunits in the brains of APP23 mice and AD patients. Moreover,...
Danlei Bi

The p3 peptides (Aβ<sub>17-40/42</sub>) rapidly form amyloid fibrils that cross-seed with full-length Aβ

6 months 2 weeks ago
The p3 peptides, Aβ(17-40/42), are a common alternative cleavage product of the amyloid precursor protein, and are found in diffuse amyloid deposits of Alzheimer's and Down Syndrome brains. The p3 peptides have been mis-named 'non-amyloidogenic'. Here we show p3(40/42) peptides rapidly form amyloid fibrils, with kinetics dominated by secondary nucleation. Importantly, cross-seeding experiments, with full-length Aβ induces a strong nucleation between p3 and Aβ peptides. The cross-seeding...
Yao Tian