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US and China sign new science pact — but with severe restrictions
The skin’s ‘surprise’ power: it has its very own immune system
The CALERIE Genomic Data Resource
Inhere, Outthere
The best science images of 2024 — <i>Nature’s</i> picks
Addressing interconnect challenges for enhanced computing performance
Science, Volume 386, Issue 6727, December 2024.
Neanderthal ancestry through time: Insights from genomes of ancient and present-day humans
Science, Volume 386, Issue 6727, December 2024.
Autologous DNA mobilization and multiplication expedite natural products discovery from bacteria
Science, Volume 386, Issue 6727, December 2024.
Sexual selection promotes reproductive isolation in barn swallows
Science, Volume 386, Issue 6727, December 2024.
An injury-induced mesenchymal-epithelial cell niche coordinates regenerative responses in the lung
Science, Volume 386, Issue 6727, December 2024.
Growing concerns about fate of Syria’s secret chemical weapons stashes
Scientists working on illegal programs could face war crimes charges
Declassified satellite photos reveal impacts of Vietnam War
By pinpointing bomb craters and swaths sprayed with herbicides, analysis could help direct remediation and cleanup efforts
The Himalayan tree landscape is shifting—and so are its ecosystems
At high elevations, fir trees are outcompeting once-dominant birches amid warmer, drier conditions
‘Safety signal’ in Moderna’s RSV vaccine studies halts trials of other vaccines for childhood killer
Company found signs its shots made some infected kids sicker than expected, casting a new shadow over the previously troubled RSV vaccine field
U.S. climate scientists gird for a second Trump administration
Trump allies have vowed to squash research and fire adversaries
United States and China renew science pact despite rising tensions
New agreement clarifies rules on data sharing and how to resolve disputes
Common virus may help protect skin against Sun damage
Beta human papillomavirus helps the immune system target mutated skin cells, a “provocative” mouse and human study suggests
From onset to advancement: the temporal spectrum of α-synuclein in synucleinopathies
This review provides an in-depth analysis of the complex role of alpha-synuclein (α-Syn) in the development of α-synucleinopathies, with a particular focus on its structural diversity and the resulting clinical variability. The ability of α-Syn to form different strains or polymorphs and undergo various post-translational modifications significantly contributes to the wide range of symptoms observed in disorders such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple...
African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in GBA1
Recently, an African ancestry-specific Parkinson disease (PD) risk signal was identified at the gene encoding glucocerebrosidase (GBA1). This variant ( rs3115534 -G) is carried by ~50% of West African PD cases and imparts a dose-dependent increase in risk for disease. The risk variant has varied frequencies across African ancestry groups but is almost absent in European and Asian ancestry populations. GBA1 is a gene of high clinical and therapeutic interest. Damaging biallelic protein-coding...
Rubicon regulates exosome secretion via the non-autophagic pathway
Exosomes are small extracellular vesicles (EVs), which have the diameter of 50-150 nm and originate from intralumenal vesicles in multivesicular endosomes (MVBs). Exosomes secreted from donor cells are delivered to recipient cells for transferring of exosome cargos, such as proteins, lipids and nucleic acids. The cargo transfer by exosomes has a pivotal role in cell-to-cell communication for many cellular processes; however, the detailed mechanism remains largely elusive. In our recent study, we...