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Brand-new colour created by tricking human eyes with laser
Computational design of serine hydrolases
Science, Volume 388, Issue 6744, April 2025.
The genetic architecture of cell type–specific cis regulation in maize
Science, Volume 388, Issue 6744, April 2025.
Structural basis for nucleolin recognition of MYC promoter G-quadruplex
Science, Volume 388, Issue 6744, April 2025.
Deep-tissue transcriptomics and subcellular imaging at high spatial resolution
Science, Volume 388, Issue 6744, April 2025.
Adaptation repeatedly uses complex structural genomic variation
Science, Volume 388, Issue 6744, April 2025.
Casz1 is required for both inner hair cell fate stabilization and outer hair cell survival
Science, Volume 388, Issue 6744, April 2025.
NSF starts to kill grants that violate Trump’s war on diversity efforts
Attracting women and minorities into science and studying misinformation are no longer priorities, agency says
Trump swings budget ax at USGS biology research
Plan to eliminate $307 million ecosystem program could face obstacles in Congress
NIH halts more collaborations with South Africa on HIV/AIDS trials
International networks told not to start new studies or enroll new trial participants in the country
What’s the deal with dire wolves? Iconic predators may have been ‘the Neanderthals of the wolf world’
New analysis of ancient DNA has been overshadowed by the controversy over de-extinction and genetically edited gray wolf pups
Trump administration targets academic journals with attorney letter, proposed funding cuts
Budget plan would kill two CDC journals, while U.S. prosecutor accuses some nongovernmental publications of being “partisans”
NIH freezes funds to Harvard and four other universities, but can’t tell them
Move follows broader White House attack on Harvard funding and stop-work orders to contractors
NSF halts project to improve radar on hurricane hunters
Technical problems and budget squeeze combine to derail $92 million phased array
Sexual misconduct helpline offers support for NSF community
The resource is an expansion of the agency’s efforts to address harassment in the U.S. Antarctic Program
Alien planet’s atmosphere bears chemical hints of life, astronomers claim
A study suggests a distant world has gases linked on Earth to algae, but others urge caution before invoking alien slime
Trump wants to log more forests. Will it really help prevent wildfires?
The approach may only work in some places, researchers say
MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson's disease-associated dopaminergic neuron loss
MIRO1 is a mitochondrial outer membrane protein important for mitochondrial distribution, dynamics and bioenergetics. Over the last decade, evidence has pointed to a link between MIRO1 and Parkinson's disease (PD) pathogenesis. Moreover, a heterozygous MIRO1 mutation (p.R272Q) was identified in a PD patient, from which an iPSC-derived midbrain organoid model was derived, showing MIRO1 mutant-dependent selective loss of dopaminergic neurons. Herein, we use patient-specific iPSC-derived midbrain...
Anti-amyloid could help prevent genetic form of Alzheimer's disease
No abstract
Mnemonic brain state engagement is diminished in healthy aging
Healthy older adults typically show impaired episodic memory - memory for when and where an event occurred. This selective episodic memory deficit may arise from differential engagement in the retrieval state, a brain state in which attention is focused internally in an attempt to access prior knowledge, and the encoding state, a brain state which supports the formation of new memories and that trades off with the retrieval state. We hypothesize that older adults are biased toward a retrieval...