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To combat antimicrobial resistance, invest in test-to-treat strategies
My identity was stolen by a predatory conference
A triple rainbow all the way across the sky — 150 years ago
UN Pact for the Future: Scientists must step up to accelerate sustainability goals
Pediatrics academy accused of “fearmongering” over GMO ingredients in kids’ diets
New guidelines asserting pesticide dangers wrongly favor organic foods over cheaper ones, critics say
In the dark ocean, these tiny creatures can smell their way home
Commuting crustaceans can sense water from the caves where they live
Olfactory deficit and gastrointestinal dysfunction precede motor abnormalities in alpha-Synuclein G51D knock-in mice
Parkinson's disease (PD) is typically a sporadic late-onset disorder, which has made it difficult to model in mice. Several transgenic mouse models bearing mutations in SNCA, which encodes alpha-Synuclein (α-Syn), have been made, but these lines do not express SNCA in a physiologically accurate spatiotemporal pattern, which limits the ability of the mice to recapitulate the features of human PD. Here, we generated knock-in mice bearing the G51D SNCA mutation. After establishing that their motor...
Ageing, proteostasis, and the gut: Insights into neurological health and disease
Recent research has illuminated the profound bidirectional communication between the gastrointestinal tract and the brain, furthering our understanding of neurological ailments facilitating possible therapeutic strategies. Technological advancements in high-throughput sequencing and multi-omics have unveiled significant alterations in gut microbiota and their metabolites in various neurological disorders. This review provides a thorough analysis of the role of microbiome-gut-brain axis in...
Author Correction: Serum proteomics reveal APOE-epsilon4-dependent and APOE-epsilon4-independent protein signatures in Alzheimer's disease
No abstract
Challenges and recommendations for the translation of biomarkers of aging
Author Correction: Serum proteomics reveal <i>APOE-ε4</i>-dependent and <i>APOE-ε4</i>-independent protein signatures in Alzheimer’s disease
Where did viruses come from? AlphaFold and other AIs are finding answers
Daily briefing: Common diabetes drug slows monkey brain-ageing
The Burning Earth: how conquest and carnage have decimated landscapes worldwide
Forget ChatGPT: why researchers now run small AIs on their laptops
Mosquito-borne diseases are surging in Europe — how worried are scientists?
When physicists strove for peace: past lessons for our uncertain times
I fire darts at whales to help track their movements
Islands are rich with languages spoken nowhere else
Understanding exogenous factors and biological mechanisms for cognitive frailty: A multidisciplinary scoping review
Cognitive frailty (CF) is the conjunction of cognitive impairment without dementia and physical frailty. While predictors of each element are well-researched, mechanisms of their co-occurrence have not been integrated, particularly in terms of relationships between social, psychological, and biological factors. This interdisciplinary scoping review set out to categorise a heterogenous multidisciplinary literature to identify potential pathways and mechanisms of CF, and research gaps. Studies...