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Arctic bird nesting traces back to the Cretaceous

9 months 2 weeks ago
Science, Volume 388, Issue 6750, Page 974-978, May 2025.
Lauren N. Wilson, Daniel T. Ksepka, John P. Wilson, Jacob D. Gardner, Gregory M. Erickson, Donald Brinkman, Caleb M. Brown, Jaelyn J. Eberle, Chris L. Organ, Patrick S. Druckenmiller

Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review

9 months 2 weeks ago
This systematic review aimed to evaluate and synthesize the scientific evidence of virtual reality (VR) interventions on quality of life, cognitive function, and physical function in older people with Alzheimer's disease (AD). A systematic review search until March 2025 using seven generic databases: PubMed, EBSCOhost, CINAHL Complete, Cochrane, ProQuest, Scopus, and Web of Science. The PRISMA, RoB 2, and GRADEpro tools were used to assess the methodological quality, risk of bias, and certainty...
Edgar Vásquez-Carrasco

Exploring the combined neuroprotective effects of resveratrol and hesperidin in a scopolamine-induced rat model of cognitive impairment

9 months 2 weeks ago
The occurrence of cognitive impairment in normal aging and sporadic Alzheimer's disease is linked to oxidative stress. Resveratrol, a polyphenolic molecule, and hesperidin, a flavanone glycoside have exhibited powerful anti-oxidant and neuroprotective effects. The present study was designed to explore the neurotherapeutic potential of combination between resveratrol and hesperidin as preventative herbal remedies to inhibit oxidative stress and cholinergic and mitochondrial dysfunction in...
Bedanta Bhattacharjee

Effectiveness of virtual reality interventions on quality of life, cognitive function and physical function in older people with Alzheimer's disease: A systematic review

9 months 2 weeks ago
This systematic review aimed to evaluate and synthesize the scientific evidence of virtual reality (VR) interventions on quality of life, cognitive function, and physical function in older people with Alzheimer's disease (AD). A systematic review search until March 2025 using seven generic databases: PubMed, EBSCOhost, CINAHL Complete, Cochrane, ProQuest, Scopus, and Web of Science. The PRISMA, RoB 2, and GRADEpro tools were used to assess the methodological quality, risk of bias, and certainty...
Edgar Vásquez-Carrasco

Exploring the combined neuroprotective effects of resveratrol and hesperidin in a scopolamine-induced rat model of cognitive impairment

9 months 2 weeks ago
The occurrence of cognitive impairment in normal aging and sporadic Alzheimer's disease is linked to oxidative stress. Resveratrol, a polyphenolic molecule, and hesperidin, a flavanone glycoside have exhibited powerful anti-oxidant and neuroprotective effects. The present study was designed to explore the neurotherapeutic potential of combination between resveratrol and hesperidin as preventative herbal remedies to inhibit oxidative stress and cholinergic and mitochondrial dysfunction in...
Bedanta Bhattacharjee

Aging and immunity: the age-old tango

9 months 2 weeks ago
The rising global demographic aging and the subsequent increase in the prevalence of age-related diseases highlight the need to understand aging biology. A key player in organismal aging is the immune system, which has broad systemic effects. On the one hand, immune aging involves the decline of hematopoietic stem cells and significant alterations in the functionality and composition of both innate and adaptive immunity. On the other hand, the aged immune system contributes to chronic...
Inés Fernández Maestre

Subcortical brain volumetric differences related to white matter lesion volume and cognition in healthy aging

9 months 2 weeks ago
White matter hyperintensity (WMH) lesions associated with small vessel cerebrovascular disease (CVD) are common structural neuroimaging findings in older adults. Greater global brain WMH burden related to aging has been implicated in dementia but has also been linked to brain atrophy and cognitive dysfunction in old age. We sought to investigate the regionally distributed association of global WMH lesion load with subcortical gray matter (SGM) volumes using a multivariate network analysis method...
Hyun Song

Cross-tissue multicellular coordination and its rewiring in cancer

9 months 2 weeks ago
The multicellular coordination that underlies tissue homeostasis and disease progression is of fundamental interest^(1-5). However, how diverse cell types are organized within tissue niches for cohesive functioning remains largely unknown. Here we systematically characterized cross-tissue coordinated cellular modules in healthy tissues, uncovering their spatiotemporal dynamics and phenotypic associations, and examined their rewiring in cancer. We first compiled a comprehensive single-cell...
Qiang Shi