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Formation and composition of Earth’s Hadean protocrust
Near-field photon entanglement in total angular momentum
Bifidobacteria support optimal infant vaccine responses
Mastering diverse control tasks through world models
A natural experiment on the effect of herpes zoster vaccination on dementia
Photoinduced copper-catalysed deracemization of alkyl halides
World’s tiniest pacemaker could revolutionize heart surgery
Do smartphones and social media really harm teens’ mental health?
Are screens harming teens? What scientists can do to find answers
What if human blood were toxic to mosquitoes? A drug can make it so
Why NIH labs have no supplies and April fooling at CDC: Trump Tracker
Follow President Donald Trump’s impact on U.S. research and science globally
Lawsuit aims to overturn many NIH grant terminations
Multiple groups and NIH-funded scientists challenge agency’s decision as arbitrary and capricious
Unusual dinosaur tracks in Scotland reveal an ancient watering hole
The impressions, once considered fish burrows, were found along a shoreline with a notable role in Scottish history
Stellarators, once fusion’s dark horse, hit their stride
Multiple companies aim to generate power by corraling plasma with twisted magnets
Molecular pathways and diagnosis in spatially resolved Alzheimer's hippocampal atlas
We employed Stereo-seq combined with single-nucleus RNA sequencing (snRNA-seq) to investigate the gene expression and cell composition changes in human hippocampus with or without Alzheimer's disease (AD). The transcriptomic map, with single-cell precision, unveiled AD-associated alterations with spatial specificity, which include the following: (1) elevated synapse pruning gene expression in the fimbria of AD, with disrupted microglia-astrocyte communication likely leading to disorganized...
The absence of Pitx3 results in postnatal loss of dopamine neurons and is associated with an increase in the pro-apoptotic Bcl2 factor Noxa and cleaved caspase 3
Mesodiencephalic dopamine neurons (mdDA) of the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) play critical roles in regulating movement and motivation. Pitx3 is an essential transcription factor required for proper embryonic development and terminal differentiation of mdDA neurons. Although Pitx3 is expressed in every mdDA neuron, its ablation results only in the absence of the SNc, not the VTA. The developmental stage at which the loss of SNc first becomes apparent, as...
Management of freezing of gait - mechanism-based practical recommendations
Freezing of gait (FOG) is a debilitating motor symptom that commonly occurs in Parkinson disease, atypical parkinsonism and other neurodegenerative conditions. Management of FOG is complex and requires a multifaceted approach that includes pharmacological, surgical and non-pharmacological interventions. In this Expert Recommendation, we provide state-of-the-art practical recommendations for the management of FOG, based on the latest insights into the pathophysiology of the condition. We propose...
Harnessing artificial intelligence to transform Alzheimer's disease research
No abstract
Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screening
Cerebral microhemorrhages (CMHs, also known as cerebral microbleeds) contribute to vascular cognitive impairment and dementia (VCID), with aging and hypertension being key risk factors. Mitochondrial oxidative stress is a hallmark of cerebrovascular aging, leading to endothelial dysfunction. This study tests the hypothesis that increased mitochondrial oxidative stress contributes to age-related CMH susceptibility and evaluates the mitochondrial-targeted antioxidative peptide SS-31 (elamipretide)...
Vegetarian diet and healthy aging among Chinese older adults: a prospective study
Vegetarian diets are increasingly popular worldwide, but their impact on healthy aging in older adults remains unclear. This study examined the association between vegetarian diets and healthy aging among 2,888 healthy older Chinese adults from the Chinese Longitudinal Healthy Longevity Survey. Dietary patterns (vegan, ovo-vegetarian, pesco-vegetarian, omnivorous) were derived from a simplified non-quantitative food frequency questionnaire. Over a median follow-up of 6 years, after accounting...