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The maternal X chromosome affects cognition and brain ageing in female mice
Global 3D model of mantle attenuation using seismic normal modes
Field–particle energy transfer during chorus emissions in space
Tissue-resident memory CD8 T cell diversity is spatiotemporally imprinted
Superconductivity in 5.0° twisted bilayer WSe<sub>2</sub>
Experience-dependent dopamine modulation of male aggression
Genomics yields biological and phenotypic insights into bipolar disorder
Resolving native GABA<sub>A</sub> receptor structures from the human brain
Extended quantum anomalous Hall states in graphene/hBN moiré superlattices
Neuromorphic computing at scale
The new science of menopause: these emerging therapies could change women’s health
Menopause research is globally underfunded. It’s time to change that
US scientist cleared of hiding ties to China sues university that fired him
A world less safe and secure
Science, Volume 387, Issue 6734, Page 559-559, February 2025.
Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring
Researchers facing “a lot of uncertainty, fear, and panic”
Watch these ‘walking’ corals strut their stuff
Mushroom corals roll, slide, and pulse to shuffle toward the light
Biden pardons Fauci but debars EcoHealth and its leader for actions during pandemic
Two decisions close chapter on controversies over origins of SARS-CoV-2
Biotin mitigates the development of manganese-induced, Parkinson's disease-related neurotoxicity in Drosophila and human neurons
Chronic exposure to manganese (Mn) induces manganism and has been widely implicated as a contributing environmental factor to Parkinson's disease (PD), featuring notable overlaps between the two in motor symptoms and clinical hallmarks. Here, we developed an adult Drosophila model of Mn toxicity that recapitulated key parkinsonian features, spanning behavioral deficits, neuronal loss, and dysfunctions in lysosomes and mitochondria. Metabolomics analysis of the brain and body tissues of these...
Parental origin of transgene modulates amyloid-beta plaque burden in the 5xFAD mouse model of Alzheimer's disease
In Alzheimer's disease (AD) research, the 5xFAD mouse model is commonly used as a heterozygote crossed with other genetic models to study AD pathology. We investigated whether the parental origin of the 5xFAD transgene affects plaque deposition. Using quantitative light-sheet microscopy, we found that paternal inheritance of the transgene led to a 2-fold higher plaque burden compared with maternal inheritance, a finding consistent across multiple 5xFAD colonies. This effect was not due to...
Bypassing senescence
A metabolic switch enables hepatocytes in damaged livers to escape senescence and form tumors.