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Internet use, physical activity, and cognitive function in Chinese older adults: a cross-lagged panel analysis
CONCLUSION: This study reveals the complex relationship between cognitive function, internet use, and physical activity in older adults, and provides new perspectives for interventions aimed at improving cognitive health in older adults. Future research should further explore the dynamic changes between these variables to develop more effective intervention strategies and improve cognitive health and well-being in older adults.
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Selective removal of astrocytic PERK protects against glymphatic impairment and decreases toxic aggregation of β-amyloid and tau
Dysfunction of the glymphatic system, a brain-wide waste clearance network, is strongly linked to Alzheimer's disease (AD) and the accumulation of β-amyloid (Aβ) and tau proteins. Here, we identify an astrocytic signaling pathway that can be targeted to preserve glymphatic function and mitigate neurotoxic protein buildup. Analysis of astrocytes from both human AD brains and two transgenic mouse models (5XFAD and PS19) reveals robust activation of the protein kinase RNA-like endoplasmic reticulum...
Miro1: A potential target for treating neurological disorders
The Miro1 protein is a member of the mitochondrial Rho GTPase (Miro) protein family and plays a crucial role in regulating the dynamic processes of mitochondria and participating in cellular movement and mitochondrial transport. In the nervous system, it ensures adequate energy supply for normal neuronal function and synaptic transmission. Additionally, Miro1 actively participates in the regulation of mitochondrial quality control and stress responses within neurons. Its primary function is to...