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House committees give a real boost to DOE science and shrink size of cuts to NSF and NASA science

Under new plan, universities would detail the full cost of research

But some scientists warn the research, which compared energy burned across populations, can’t reveal the epidemic’s causes

South Africa plans modest spending increase, but shortfalls will limit prevention and treatment

Wound healing in old mice is characterized by disturbed tissue homeostasis, manifested by delayed immune cell infiltration and reduced growth factor secretion, leading to a delayed onset and prolonged duration of the inflammatory phase. The endocannabinoid system (ECS) is an important regulator of tissue homeostasis and cell migration and is also considered to be subject to aging processes, which may contribute to observable aging phenomena. Therefore, stimulating the aged ECS could represent a...

CONCLUSIONS: Probable sarcopenia, indicated by low HGS, was associated with an increased risk of cognitive impairment in older men, with risk consistent across BMI strata, including men living with probable sarcopenic obesity. Our findings have clinical relevance, suggesting that phenotypes comprising low muscle strength, in the presence of excess adiposity must not be overlooked and appropriate interventions explored to attenuate physical perturbations which could carry significance towards...

The combination of an increasing life expectancy and an increasing risk of fractures in the aging population collides with the still inadequate primary and secondary fracture prevention in Europe. Osteoporotic fractures have a major impact not only on morbidity, quality of life and mortality but also on healthcare costs. Therefore, an improvement of fracture prevention is warranted. Osteoanabolic drugs are particularly beneficial in patients with very high fracture risk and are recommended by...

CONCLUSIONS AND IMPLICATIONS: The CRPS is a scientifically robust tool to assess care risk perceptions in LTCFs. By identifying caregivers' risk awareness gaps, it supports targeted interventions and policy reforms for standardized safety audits to enhance dementia care quality and safety.

As the global population ages, multimorbidity has become a critical public health issue. We analyzed 332,012 adults from the UK Biobank (2006-2022) to investigate the association between biological age-measured by the Klemera-Doubal method (KDM-BA) and phenotypic age (PhenoAge)-and a new comorbidity model encompassing physical, psychological, and cognitive disorders, with overall mortality outcomes over a median follow-up of 13.6 years. Logistic regression models examined the association between...

Malvidin-3-galactoside (M3G), an anthocyanin derived from blueberries (Vaccinium myrtillus L.), is recognized for its antioxidant and anti-inflammatory properties. In this study, Drosophila melanogaster was treated with M3G at concentrations of 1, 10, and 100 µM, while control groups received an identical diet without M3G supplementation. Treatment with M3G extended the lifespan of male flies by as much as 5% (p < 0.05). However, in females, certain concentrations of M3G resulted in reduced...

The growing population of childhood cancer survivors (CCSs) experiences a large burden of comorbidities, including a markedly increased risk of diabetes mellitus. Among CCSs, prediabetes and diabetes are important risk factors for subsequent cardiovascular disease, which is a leading cause of premature death in this patient population. The mechanisms underlying their development are multifactorial, and may differ from those in the general population. Emerging evidence from preclinical and...

Medial ganglionic eminence-derived inhibitory γ-aminobutyric acid (GABAergic) pallial interneurons (MGE-pINs) are essential regulators of cortical circuits, and their dysfunction is associated with neurological disorders. We developed human MGE-pINs from pluripotent stem cells for the treatment of drug-resistant epilepsy. Here, we analyzed xenografted MGE-pINs from human pluripotent stem cells (hMGE-pINs) over the lifespan of host mice in healthy and epileptic environments using single-nuclei...

Microglia, the resident immune sentinels of the central nervous system (CNS), engage in dynamic crosstalk with neurons, the principal units of information transmission, to maintain CNS homeostasis. Emerging research has established that dysregulation of this intricate communication network critically contributes to Alzheimer's disease (AD) pathogenesis, offering novel insights for therapeutic development. In this review, we dissect the molecular mechanisms underlying multifaceted...

CONCLUSIONS: This multidimensional approach may enable earlier identification of individuals at risk for functional decline and inform the development of targeted preventive or therapeutic interventions to promote independence and healthy aging.

In both humans and mice, the adrenal gland is a sexually dimorphic organ, but the extent of this diversity throughout development remains unclear. Here, we analyzed the mouse adrenal gland transcriptome at postnatal days 0, 7, 15, 21, 28, 35, and 49 to uncover its transcriptomic trajectory. Sex-dependent differences, indicated by the number of differentially expressed genes, gradually increase over time. Two Y-linked genes are consistently expressed in male adrenal glands, suggesting that...

The genetic basis of naturally occurring variation in organismal senescence and lifespan remains largely unknown. We quantified genome-wide gene expression levels of young and 3-week-old flies of the Drosophila Genetic Reference Panel and performed a systems genetics analysis integrating genomic, transcriptomic, and organismal phenotype variation. Aging had widespread but small effects on nearly the entire transcriptome, which were dependent on the genetic background. Although the co-expression...