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Activation of parkin by a molecular glue

5 months 2 weeks ago
Mutations in parkin and PINK1 cause early-onset Parkinson's disease (EOPD). The ubiquitin ligase parkin is recruited to damaged mitochondria and activated by PINK1, a kinase that phosphorylates ubiquitin and the ubiquitin-like domain of parkin. Activated phospho-parkin then ubiquitinates mitochondrial proteins to target the damaged organelle for degradation. Here, we present the mechanism of activation of a new class of small molecule allosteric modulators that enhance parkin activity. The...
Véronique Sauvé

In Science Journals

5 months 3 weeks ago
Science, Volume 385, Issue 6715, Page 1311-1313, September 2024.

Michael Funk, and
Corinne Simonti,
Jake S. Yeston,
Christiana N. Fogg,
Jesse Smith,
Courtney Malo,
Di Jiang,
Ian S. Osborne,
Sarah H. Ross,
Michael A. Funk,
Jelena Stajic,
Keith T. Smith,
Priscilla N. Kelly, and
Amy E. Baek

Who cares about lab rodents?

5 months 3 weeks ago
Science, Volume 385, Issue 6715, Page 1270-1273, September 2024.

Gail Davies,
Robert G. W. Kirk,
Beth Greenhough,
Pru Hobson-West,
Dmitriy Myelnikov, and
Emma Roe






Ice skater

5 months 3 weeks ago
Science, Volume 385, Issue 6715, Page 1264-1269, September 2024.

Robin George Andrews