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The landscapes of somatic mutation in normal cells inform us about the processes of mutation and selection operative throughout life, providing insight into normal ageing and the earliest stages of cancer development¹. Here, by whole-genome sequencing of 238 microdissections² from 30 individuals, including 18 with gastric cancer, we elucidate the developmental trajectories of normal and malignant gastric epithelium. We find that gastric glands are units of monoclonal cell populations that accrue...

CONCLUSION: The study highlights the strong association between elder abuse, pain with depression, especially among older female. These findings underscore the need for targeted public health interventions among vulnerable groups such as older female, and future research to explore cross- national dynamics and underlying risk factors.

The hippocampus is a complex structure critically involved in numerous behavior-regulating systems. In young adults, multiple overlapping spatial modes along its longitudinal and transverse axes describe the organization of its functional integration with neocortex, extending the traditional framework emphasizing functional differences between sharply segregated hippocampal subregions. Yet, it remains unknown whether these modes (i.e. gradients) persist across the adult human lifespan, and...

Untangling the functional organisation of a brain region crucial for memory and learning helps reveal how individual differences are linked to variations in recall ability, aging and dopamine receptor distribution.

Science, Volume 387, Issue 6740, March 2025.

Science, Volume 387, Issue 6740, March 2025.

Science, Volume 387, Issue 6741, Page 1333-1333, March 2025.

Science, Volume 387, Issue 6740, Page 1264-1266, March 2025.

Science, Volume 387, Issue 6740, Page 1237-1237, March 2025.

Science, Volume 387, Issue 6740, Page 1246-1246, March 2025.

Science, Volume 387, Issue 6740, Page 1245-1245, March 2025.