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V-ATPase Disassembly at the Yeast Lysosome-Like Vacuole Is a Phenotypic Driver of Lysosome Dysfunction in Replicative Aging

4 months 3 weeks ago
Declines in lysosomal acidification and function with aging are observed in organisms ranging from yeast to humans. V-ATPases play a central role in organelle acidification, and V-ATPase activity is regulated by reversible disassembly in many different settings. Using the yeast Saccharomyces cerevisiae as a replicative aging model, we demonstrate that V-ATPases disassemble into their V(1) and V(0) subcomplexes in aging cells, with release of V(1) subunit C (Vma5) from the lysosome-like vacuole...
Fiza Hashmi

Simulating 500 million years of evolution with a language model

4 months 3 weeks ago
Science, Volume 387, Issue 6736, Page 850-858, February 2025.
Thomas Hayes, Roshan Rao, Halil Akin, Nicholas J. Sofroniew, Deniz Oktay, Zeming Lin, Robert Verkuil, Vincent Q. Tran, Jonathan Deaton, Marius Wiggert, Rohil Badkundri, Irhum Shafkat, Jun Gong, Alexander Derry, Raul S. Molina, Neil Thomas, Yousuf A. Khan…

Squeezed dual-comb spectroscopy

4 months 3 weeks ago
Science, Volume 387, Issue 6734, Page 653-658, February 2025.
Daniel I. Herman, Mathieu Walsh, Molly Kate Kreider, Noah Lordi, Eugene J. Tsao, Alexander J. Lind, Matthew Heyrich, Joshua Combes, Jérôme Genest, Scott A. Diddams



In Science Journals

4 months 3 weeks ago
Science, Volume 387, Issue 6731, Page 257-259, January 2025.

Michael Funk, and
Sacha Vignieri,
Marc S. Lavine,
Mattia Maroso,
Phil Szuromi,
Bianca Lopez,
Amy E. Baek,
Catherine Charneski,
Priscilla N. Kelly,
Sarah H. Ross,
Corinne Simonti,
Ankit Walia,
Jesse Smith,
Brent Grocholski,
Yevgeniya…

News at a glance

4 months 3 weeks ago
Science, Volume 387, Issue 6731, Page 230-232, January 2025.

Jeffrey Brainard

Dust devil

4 months 3 weeks ago
Science, Volume 387, Issue 6731, Page 240-245, January 2025.

Meredith Wadman