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Trump’s science advisers: how they could influence his second presidency
<b>How to trick the immune system into attacking tumours</b>
Revealed: Why the fatal Huntington’s gene takes so long to cause harm
RNA molecule rejuvenates ageing mice by restoring old cells
How to be a brilliant ally to your neurodivergent lab mate
Mines for a clean-energy metal have a surprise climate effect
Why fires spread quickly in modern cities — and how to slow them down
Evolution of interorganismal strigolactone biosynthesis in seed plants
Science, Volume 387, Issue 6731, January 2025.
A panoramic view of cell population dynamics in mammalian aging
Science, Volume 387, Issue 6731, January 2025.
Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis
Science, Volume 387, Issue 6731, January 2025.
Distinct myeloid-derived suppressor cell populations in human glioblastoma
Science, Volume 387, Issue 6731, January 2025.
AI-designed proteins tackle century-old problem — making snake antivenoms
In a ‘shocker’ decision, Japan approves mpox drug that failed in two efficacy trials
Earlier European authorizations for tecovirimat are also being scrutinized in the face of fresh data
National Academies panel embraces new index to measure transportation ‘insecurity’
Knowing needs of riders is key to improving transportation equity, new report says
These salamanders get around on ‘lakes of blood’
Controlling blood flow to their toes may help the amphibians stick to, and unstick from, their surroundings
A ‘ticking DNA clock’ in brain cells drives the progression of Huntington disease
Genetic stutters that expand during a person’s life explain why the disorder takes so long to develop—and could point the way to new therapies
Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation
Neuraminidase 1 (NEU1) cleaves terminal sialic acids from sialoglycoproteins in endolysosomes and at the plasma membrane. As such, NEU1 regulates immune cells, primarily those of the monocytic lineage. Here, we examine how Neu1 influences microglia by modulating the sialylation of full-length Trem2 (Trem2-FL), a multifunctional receptor that regulates microglial survival, phagocytosis, and cytokine production. When Neu1 is deficient/downregulated, Trem2-FL remains sialylated, accumulates...
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
Cellular senescence, a hallmark of aging, involves a stable exit from the cell cycle. Senescent cells (SnCs) are closely associated with aging and aging-related disorders, making them potential targets for anti-aging interventions. In this study, we demonstrated that human embryonic stem cell-derived exosomes (hESC-Exos) reversed senescence by restoring the proliferative capacity of SnCs in vitro. In aging mice, hESC-Exos treatment remodeled the proliferative landscape of SnCs, leading to...
Exercise and exerkines: Mechanisms and roles in anti-aging and disease prevention
Aging is a complex biological process characterized by increased inflammation and susceptibility to various age-related diseases, including cognitive decline, osteoporosis, and type 2 diabetes. Exercise has been shown to modulate mitochondrial function, immune responses, and inflammatory pathways, thereby attenuating aging through the regulation of exerkines secreted by diverse tissues and organs. These bioactive molecules, which include hepatokines, myokines, adipokines, osteokines, and...
Age-Trajectories of Higher-Order Diffusion Properties of Major Brain Metabolites in Cerebral and Cerebellar Gray Matter Using In Vivo Diffusion-Weighted MR Spectroscopy at 3T
Healthy brain aging involves changes in both brain structure and function, including alterations in cellular composition and microstructure across brain regions. Unlike diffusion-weighted MRI (dMRI), diffusion-weighted MR spectroscopy (dMRS) can assess cell-type specific microstructural changes, providing indirect information on both cell composition and microstructure through the quantification and interpretation of metabolites' diffusion properties. This work investigates age-related changes...