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The importance of family-based sampling for biobanks
Machine-guided design of cell-type-targeting <i>cis</i>-regulatory elements
Scalable watermarking for identifying large language model outputs
Global influence of soil texture on ecosystem water limitation
Selection bias obfuscates the discovery of fast radio burst sources
Bureaucrat incentives reduce crop burning and child mortality in South Asia
Large-scale medieval urbanism traced by UAV–lidar in highland Central Asia
Anti-viral defence by an mRNA ADP-ribosyltransferase that blocks translation
This plankton balloons in size to soar upwards through the water
Why a fortunate few don’t get ill after HIV infection
Uncovering a lost mountain metropolis
Long-term lineage commitment in hematopoietic stem cell gene therapy
Publisher Correction: Using both faces of polar semiconductor wafers for functional devices
Molecular mechanism of IgE-mediated FcεRI activation
METTL3 governs thymocyte development and thymic involution by regulating ferroptosis
How to run a successful internship programme
Is it time to give up trying to save coral reefs? My research says no
DNA ‘printing press’ could quickly store mountains of data
Inspired by ancient invention of movable type, researchers use blocks of DNA to dramatically increase writing speed
Differentiating visceral sensory ganglion organoids from induced pluripotent stem cells
The ability to generate visceral sensory neurons (VSN) from induced pluripotent stem (iPS) cells may help to gain insights into how the gut-nerve-brain axis is involved in neurological disorders. We established a protocol to differentiate human iPS-cell-derived visceral sensory ganglion organoids (VSGOs). VSGOs exhibit canonical VSN markers, and single-cell RNA sequencing revealed heterogenous molecular signatures and developmental trajectories of VSGOs aligned with native VSN. We integrated...
Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis
Senescent neural progenitor cells have been identified in brain lesions of people with progressive multiple sclerosis (PMS). However, their role in disease pathobiology and contribution to the lesion environment remains unclear. By establishing directly induced neural stem/progenitor cell (iNSC) lines from PMS patient fibroblasts, we studied their senescent phenotype in vitro. Senescence was strongly associated with inflammatory signaling, hypermetabolism, and the senescence-associated secretory...