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Impact of population ageing on stroke-related disability-adjusted life years: a global decomposition analysis
CONCLUSIONS: Population ageing is a dominant driver of the growing global stroke burden, necessitating targeted public health interventions for ageing populations.
Association between perceived neighborhood environment, sedentary behavior, walking, and moderate-to-vigorous physical activity and frailty: an isotemporal substitution model
CONCLUSIONS: Replacing SB with walking and improving neighborhood accessibility were significantly associated with reduced risk of being pre-frail or frail. These findings highlight the importance of considering these factors when designing age-friendly environments for older adults.
Dysregulated calcium signaling in the aged primate association cortices: vulnerability to Alzheimer's disease neuropathology
The common, late onset form of Alzheimer's disease (AD) selectively impacts higher brain circuits, with tau pathology and neurodegeneration preferentially afflicting glutamatergic neurons in the limbic and association cortices. Understanding this selective vulnerability may help reveal the etiology of sporadic AD and therapeutic targets for prevention. The current review describes that these vulnerable circuits express magnified calcium signaling needed for higher cognition and memory, but that...
Nonlinear associations of depression and sleep duration with cognitive impairment in older adults with hypertension: findings from a national survey
CONCLUSION: This study highlights the importance of managing depression and optimizing sleep duration in addressing the risk of cognitive decline in older adults with hypertension.
These ancient tattoos show the work of a master and apprentice
A mummy’s inked skin sheds light on the history of body art