Aggregator
Tissue Resident Memory Cells: Friend or Foe?
Tissue-resident memory T (T(RM)) cells are a specialised subset of immune cells that remain within tissues, playing a vital role in localised immune defence and long-term immunity. Unlike circulating memory T cells, T(RM) cells do not recirculate to provide rapid and effective responses against previously encountered pathogens at the tissue level. The formation of T(RM) cells is driven by tissue-specific cues, guiding their differentiation and retention within organs such as the skin, lungs and...
Exclusive: retraction-prone editors identified at megajournal <i>PLoS ONE</i>
Why I co-developed a research career launchpad for first generation students
Eating ultra-processed foods could make it harder to lose weight
Direct identification of Ac and No molecules with an atom-at-a-time technique
Real-time in-situ magnetization reprogramming for soft robotics
What it’s like fighting racism and sexism in shark science
To save lives in heatwaves, focus on how human bodies work
We need a new ethics for a world of AI agents
Environmental politics is doomed to fail — unless we tell better stories
This company claimed to ‘de-extinct’ dire wolves. Then the fighting started.
Glow-in-the-dark marsupial shows off its luminous fur — July’s best science images
How I’m electrifying transportation in Tanzania
One-fifth of computer science papers may include AI content
A surge in AI-generated text has been detected in papers across many disciplines since the release of ChatGPT
Scientific fraud has become an ‘industry,’ alarming analysis finds
Sophisticated global networks are infiltrating journals to publish fake papers
High estimated pulse-wave velocity is associated with lower brain white matter microstructural integrity twelve years later
High pulse wave velocity (PWV), a measure of increased arterial stiffness, is a risk factor for cerebrovascular disease. PWV can be estimated (ePWV) from age and blood pressure (BP). Elevated ePWV is associated with cerebral small-vessel disease, cognitive decline, and dementia risk in middle-aged and older adults. We examined data from the Midlife in the United States (MIDUS) Neuroscience Project to examine the association of ePWV with brain white matter microstructure. BP was measured in 132...
Transition Between Healthy Aging and Renal Dysfunction During Natural Aging: Role Of p21, p16, NADPH Oxidase, NFkB, and COX-2
CONCLUSION: These findings highlight a critical transitional phase in kidney aging, where early senescence and oxidative stress emerge before functional decline. COX-2 may serve as a central mediator in this process, offering a potential therapeutic target for mitigating age-related renal dysfunction.
A narrative review and expert consensus on barriers, facilitators, and research gaps to healthy and positive ageing - Position of the Multidisciplinary International Positive Ageing Group (MIPAG)
Recent developments in healthcare and scientific research have shifted the perception of ageing from a period of decline to recognising its potential for sustained functional ability, well-being, and societal contributions. In light of this perspective, a multidisciplinary panel of experts from five European countries conducted a narrative review of the literature. It convened for a one-day consensus meeting to identify key barriers, facilitators, and research priorities related to healthy...
Aging-induced semaphorin 7a promotes TGF-beta1-mediated cell plasticity and breast tumor metastases
Breast cancer risk is transiently increased in postpartum women, and this risk is prolonged in women whose first childbirth occurs after age 30. We observe elevated semaphorin 7a (SEMA7A) in tumor tissues from patients with breast cancer aged 31-39 diagnosed <10 years after childbirth. In the aged normal murine mammary gland, transforming growth factor β+ (TGF-β+) cells have increased levels of surface SEAM7A compared to the young. TGF-β1 induces SEMA7A expression in non-transformed mammary...
Single-cell multiregion epigenomic rewiring in Alzheimer's disease progression and cognitive resilience
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, yet its epigenetic underpinnings remain elusive. Here, we generate and integrate single-cell epigenomic and transcriptomic profiles of 3.5 million cells from 384 postmortem brain samples across 6 regions in 111 AD and control individuals. We identify over 1 million candidate cis-regulatory elements (cCREs), organized into 123 regulatory modules across 67 cell subtypes. We define large-scale...