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Long-distance coherent quantum communications in deployed telecom networks
Effects of glacial forcing on lithospheric motion and ridge spreading
Atomic lift-off of epitaxial membranes for cooling-free infrared detection
Cold memories control whole-body thermoregulatory responses
Deciphering disordered regions controlling mRNA decay in high-throughput
Carbon majors and the scientific case for climate liability
Superconducting gap of H<sub>3</sub>S measured by tunnelling spectroscopy
Psychedelic control of neuroimmune interactions governing fear
China overtakes the United States in cancer research output
Ancient DNA reveals Phoenicians’ surprising genetic ancestry
An origami design for metamaterial robots
Geographic and age variations in mutational processes in colorectal cancer
Publisher Correction: Oncolytic virus VG161 in refractory hepatocellular carcinoma
Whole-body physics simulation of fruit fly locomotion
Author Correction: Global influence of soil texture on ecosystem water limitation
Paying fishers to release sharks could backfire
Proposed conservation strategy led to more hammerhead shark deaths than usual, study finds
‘Terrible crocodile’ was not related to modern alligators
A new analysis finds supersize crocodilians evolved more frequently than scientists once thought
Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition
Triplications and certain point mutations in the SNCA gene, encoding alpha-synuclein (α-Syn), cause Parkinson's disease (PD). Here, we demonstrate that the PD-causing A53T α-Syn mutation and elevated α-Syn expression perturb acetyl-coenzyme A (CoA) and p300 biology in human neurons and in the CNS of zebrafish and mice. This dysregulation is mediated by activation of ATP-citrate lyase (ACLY), a key enzyme that generates acetyl-CoA in the cytoplasm, via two mechanisms. First, ACLY activity...
Microglia drive amyloid-beta clearance in immunized patients with Alzheimer's disease
No abstract
The mammalian longevity associated acetylome
Despite extensive studies at the genomic, transcriptomic and metabolomic levels, the underlying mechanisms regulating longevity are incompletely understood. Post-translational protein acetylation is suggested to regulate aspects of longevity. To further explore the role of acetylation, we develop the PHARAOH computational tool based on the 100-fold differences in longevity within the mammalian class. Analyzing acetylome and proteome data across 107 mammalian species identifies 482 and 695...