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A dependency map enhanced with next-generation 3D cancer models
Amygdala astrocyte primary cilium mechanisms contribute to stress behaviours
In situ particle-to-fibre transformation of hydrogels for 3D printing
ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer
Ubiquitous Kelvin–Helmholtz instabilities driving plasma mixing on the Sun
An expanded codebook of human transcription factor DNA-binding specificity
<b>Junk plastic turns into high-value commodity with chemistry trick</b>
Editorial Expression of Concern: Tumour exosome integrins determine organotropic metastasis
Thermally evaporated perovskite/silicon tandems via formamidinium eutectic
The recovered notes of Professor Alborough
Exclusive: the science papers that patents cite the most
James Bond, not Bond James: why scientific publishing must respect name order
Publisher Correction: Progressive plasticity during colorectal cancer metastasis
NIH Director Bhattacharya kills more health disparities grants
Letter says agency is “adjusting its extramural research portfolio, which includes terminating grant awards”
‘I Am What I Am’: Fauci’s private notes reveal a scientist navigating science, politics, and fame
Diary entries from the retired NIAID director address presidential relationships, “crazy RFK,” and death threats
Stanford scientists discover immune cells that explode like microscopic bombs
Stanford researchers discovered immune cells in flatworms that explode within minutes, killing nearby bacteria and foreign cells before vanishing completely. Their unusually fast and localized attack could offer clues for developing targeted treatments against infections and cancer.
Cancer-fighting chewing gum cuts HPV levels by up to 93%
A specially engineered chewing gum reduced HPV by up to 93% and nearly eliminated two bacteria linked to head and neck cancer. The treatment preserved beneficial mouth bacteria, raising hopes for a safer and more affordable therapy.
When lactate speaks: Rewiring astrocyte-neuron metabolism in Alzheimer's disease
Metabolic dysfunction is a defining but poorly understood feature of Alzheimer's disease. Du et al. show that a brain-penetrant GLP-1 receptor agonist rewires astrocyte-neuron metabolic coupling through lactate-driven histone lactylation, linking astrocytic glycolysis to neuronal lipid homeostasis and positioning metabolite signaling as a therapeutic axis in neurodegeneration.
How do energy metabolism disorders and neuroinflammation collectively contribute to the pathogenesis of Alzheimer's disease?
Alzheimer's disease (AD), as the leading cause of dementia, poses an increasingly severe socioeconomic burden in the context of global ageing. Traditionally defined by amyloid-β and tau pathology, it's increasingly recognized as a systems disorder in which impaired glucose metabolism, mitochondrial dysfunction, and neuroinflammation interact across neural cell types and disease stages. However, the interaction among these three mechanisms, their role in promoting the classical pathology of AD,...
An updated patent review of mGlu5 negative allosteric modulators (2018 - present)
Metabotropic glutamate receptor subtype 5 (mGlu5) is an important regulator of excitatory neurotransmission and remains a therapeutic target for neuropsychiatric and neurological disorders, including substance use disorders, depression, Fragile X syndrome, Parkinson's disease-related dyskinesia, and other movement disorders. However, the clinical development of mGlu5 negative allosteric modulators (NAMs) has been limited by translational challenges, inconsistent efficacy, and safety concerns,...