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Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health
Aging is the primary risk factor for many neuromuscular (NM) diseases that impair motor and cognitive function. Transplantation of young muscle-derived stem/progenitor cells (MDSPCs) has shown remarkable therapeutic potential across a range of age-related diseases, primarily through paracrine mechanisms. In this study, secretome profiling of young MDSPCs revealed a unique enrichment of pro-angiogenic and immunomodulatory proteins compared to their aged counterparts. Our systemic transplantation...
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Science, Volume 391, Issue 6786, February 2026.
Erratum for the Research Article “WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring”
Science, Volume 391, Issue 6786, February 2026.
Erratum for the Research Article “Of the first five US states with food waste bans, Massachusetts alone has reduced landfill waste”
Science, Volume 391, Issue 6786, February 2026.
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
Science, Volume 391, Issue 6786, February 2026.
Mitochondrial control of fuel switching via carnitine biosynthesis
Science, Volume 391, Issue 6786, February 2026.
Detecting supramolecular organic nanoparticles during heat wave
Science, Volume 391, Issue 6786, February 2026.
Structural ontogeny of protein-protein interactions
Science, Volume 391, Issue 6786, February 2026.
Poxvirus attack of antiviral defense pathways unleashes an effector-triggered NF-κB response
Science, Volume 391, Issue 6786, February 2026.
Transcription factor Etv3 controls the tolerogenic function of dendritic cells
Science, Volume 391, Issue 6786, February 2026.
Myelin sheaths in the central nervous system can withstand damage and dynamically remodel
Science, Volume 391, Issue 6786, February 2026.