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Bioelectronic devices implanted on peripheral nerves offer potential for the treatment and rehabilitation of clinical diseases. However, the foreign body reaction and the subsequent fibrous capsule formation at the device-peripheral nerve interface severely limit their efficacy and longevity in vivo. Here, we describe a robust bioadhesive strategy that can establish nonfibrotic bioelectronic interfaces on diverse peripheral nerves-occipital, vagus, deep peroneal, sciatic, tibial, and common...

New study fills major gap in genetic map of ancient human migrations

CONCLUSIONS: It may be beneficial to find ways to help such individuals feel included in society.

Impaired wound healing in aged and diabetic wounds involves complex cellular dysregulation that hinders tissue repair. Using single-cell RNA sequencing (scRNA-seq) and validation techniques, we investigated impaired wound healing to identify whether there were significant changes linked to each condition. Comparative mucosal wound analysis revealed distinct differences between diabetic and normoglycemic (NG)-aged mice, which had an impact on connective tissue formation and epithelial closure....

Motor learning refers to a set of processes associated with practice and experience that are essential for acquiring new skills and adapting behavior throughout the lifespan. Mastery of motor skills plays a crucial role in maintaining autonomy and quality of life, particularly in aging populations. This learning process relies on internal neural mechanisms that lead to enduring changes in movement capability, yet the underlying functional and anatomical adaptations in sensorimotor circuits...

CONCLUSION: Both sensory and cognitive-affective dimensions of pain, along with pain chronicity, are independently associated with postural stability impairments in older adults. These findings support the integration of multidimensional pain assessments in clinical balance evaluations.