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Multivariable Mendelian randomization study supports the causal effects of circulating metabolites on frailty
Aging-related frailty increases the risk of falls, disability, and mortality. Frailty is linked to abnormalities in whole-body metabolism. However, the causal relationship between circulating metabolic traits and frailty remains unclear. This study aims to clarify the causal effects of circulating metabolites on frailty. We used bidirectional two sample and multivariable Mendelian Randomization (MVMR) methods to assess associations between circulating metabolites and the Frailty Index (FI)....
The interplay between physical exercise and autophagy signaling in brain health, neurodegenerative diseases and aging
Brain health is increasingly recognized as a critical component of overall wellbeing, particularly concerning neurodegenerative diseases, which are characterized by the progressive degeneration of the nervous system. Conditions such as Alzheimer's disease (AD) and Parkinson's disease, together with less common disorders, resembling Amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), significantly impact cognitive and physical health, affecting over 50 million individuals...
Neuromotor functions across the lifespan: percentiles from 6 to 80 years
AIM: To investigate the dynamics of neuromotor functions from 6 to 80 years with the Zurich Neuromotor Assessment (ZNA) and to provide reference curves for clinical and research use.