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Several widely used epigenetic clocks have been developed for mice and other species, but a persistent challenge remains: different mouse clocks often yield inconsistent results. To address this limitation in robustness, we present EnsembleAge, a suite of ensemble-based epigenetic clocks. Leveraging data from over 200 perturbation experiments across multiple tissues, EnsembleAge integrates predictions from multiple penalized models. Empirical evaluations demonstrate that EnsembleAge outperforms...

Autophagic decline accompanies age and causes a deterioration in proteostasis, rendering neuronal demise. Rab27 functions as a vesicle regulator for macroautophagic/autophagic degradation and exocytosis. Loss of Drosophila Rab27 in αβp brain neurons enhances longevity, underscoring its neuronal role and systemic effect. To understand the underlying mechanisms, we characterized the cell autonomous and non-autonomous functions of Rab27. Rab27 expression increased in midlife, providing a temporal...

Modern cell therapies are designed to harness natural biology to treat a range of complex diseases. The field of immunology has shown that B cells exhibit multiple unique features, including a natural propensity to interact with and regulate other immune cells, a high capacity to produce proteins, and a long cellular lifespan, which are being creatively applied in engineered B cell (eB cell) therapies. In recent years, advances in genome editing technologies and animal modeling have facilitated...

Aging is a risk factor for the development of chronic diseases; however, it is heterogeneous. Measuring aging in midlife, commonly done using laboratory markers and statistical methods for estimation of biological age (BA), cannot directly inform behavioral intervention goals aiming to promote healthier aging. The Midlife Aging and Performance Study (MAPS) examined the association between an extended, inclusive assessment of physical capacity (PC), as a behavioral marker of aging, and BA,...

Naringin is an antioxidant flavonoid rich in diverse plant species, including citrus plants. While the antioxidant activity of naringin is well documented, there has been limited research on its anti-aging potential. The aim of this study is to investigate the in vivo anti-aging effects of naringin in the budding yeast Saccharomyces cerevisiae as a model. Our findings showed that naringin substantially increased cell viability during the chronological lifespan of wild-type yeast by mitigating...

CONCLUSION: Individuals of advanced age are susceptible to accidents in their domestic environments. A wide spectrum of factors contributes to the occurrence of such accidents. The prevention of home accidents requires an awareness of the risk factors involved, an enhancement of programs designed to facilitate healthy aging, and an increased emphasis on preventive measures. Some lifestyle modifications (exercise, nutritional therapy, home design, and the use of assistive devices) can be employed...

Autophagic decline accompanies age and causes a deterioration in proteostasis, rendering neuronal demise. Rab27 functions as a vesicle regulator for macroautophagic/autophagic degradation and exocytosis. Loss of Drosophila Rab27 in αβp brain neurons enhances longevity, underscoring its neuronal role and systemic effect. To understand the underlying mechanisms, we characterized the cell autonomous and non-autonomous functions of Rab27. Rab27 expression increased in midlife, providing a temporal...

INTRODUCTION: The neural dynamics underlying cognition and behavior change greatly during the lifespan of brain development and aging. EEG is a promising modality due to its high temporal resolution in capturing neural oscillations. Precise prediction of brain age (BA) based on EEG is crucial to screening high-risk individuals from large cohorts. However, the lifespan representation of the EEG oscillatory features (OSFs) is largely unclear, limiting practical BA applications in clinical...

Microglia are the resident immune cells of the brain. Over the past two decades, they have been shown to play critical roles throughout life. Microglia are now considered to be important for brain formation, maturation, activity and plasticity, with outcomes on behavior and other cognitive domains. With this knowledge, microglia represent a promising therapeutic target to promote brain health along an aging trajectory. Emerging evidence also indicates that modifiable lifestyle factors for...