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Homeostasis of a representational map in the neocortex

3 months 1 week ago
Cortical function, including sensory processing, is surprisingly resilient to neuron loss during aging and neurodegeneration. In this Article, we used the mouse auditory cortex to investigate how homeostatic mechanisms protect the representational map of sounds after neuron loss. We combined two-photon calcium imaging with targeted microablation of 30-40 sound-responsive neurons in layer 2/3. Microablation led to a temporary disturbance of the representational map, but it recovered in the...
Takahiro Noda

Examining the longitudinal influence of loneliness on healthcare utilization: evidence from Taiwan's national health insurance data

3 months 1 week ago
CONCLUSIONS: By merging national data and distinguishing emotional from social loneliness, this study offers insights into their differential impacts on healthcare utilization among older adults in Taiwan. It emphasizes the importance of addressing loneliness to improve physical and mental well-being and optimize the effective utilization of healthcare resources.
Shiau-Fang Chao

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures

3 months 1 week ago
Advancements in human induced pluripotent stem cell (hiPSC) technology have enabled co-culture models for disease modeling in physiologically relevant systems. However, co-culturing protocols face challenges in usability and consistency. Here, we introduce a robust, reproducible hiPSC-derived co-culture system integrating astrocytes, neurons, and microglia. This model leverages cryopreserved cells, enabling co-cultures within 20 days post-thaw. Comparing monocultures and tricultures, we...
Alexandra M Lish

Is taurine an aging biomarker?

3 months 1 week ago
Low circulating taurine concentrations have been proposed as a driver of the aging process. We found that circulating taurine concentrations increased or remained unchanged with age in three geographically distinct human cohorts as well as in nonhuman primates and mice when measured longitudinally (repeatedly in the same population) or cross-sectionally (sampling distinct populations at various ages). Moreover, considerable variability was observed in associations between taurine and age-related...
Maria Emilia Fernandez

Context-dependent modulations of subthalamo-cortical synchronization during rapid reversals of movement direction in Parkinson's disease

3 months 1 week ago
The role of beta band activity in cortico-basal ganglia interactions during motor control has been studied extensively in resting-state and for simple movements, such as button pressing. However, little is known about how beta oscillations change and interact in more complex situations involving rapid changes of movement in various contexts. To close this knowledge gap, we combined magnetoencephalography (MEG) and local field potential recordings from the subthalamic nucleus (STN) in Parkinson's...
Lucie Winkler