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Direct photoreception by pituitary endocrine cells regulates hormone release and pigmentation
Science, Volume 387, Issue 6729, Page 43-48, January 2025.
Sensation is dispensable for the maturation of the vestibulo-ocular reflex
Science, Volume 387, Issue 6729, Page 85-90, January 2025.
Organic ionic plastic crystals having colossal barocaloric effects for sustainable refrigeration
Science, Volume 387, Issue 6729, Page 56-62, January 2025.
Competitive social feedback amplifies the role of early life contingency in male mice
Science, Volume 387, Issue 6729, Page 81-85, January 2025.
Sulfenylnitrene-mediated nitrogen-atom insertion for late-stage skeletal editing of N-heterocycles
Science, Volume 387, Issue 6729, Page 102-107, January 2025.
Tantalum-stabilized ruthenium oxide electrocatalysts for industrial water electrolysis
Science, Volume 387, Issue 6729, Page 48-55, January 2025.
Canadian forests are more conducive to high-severity fires in recent decades
Science, Volume 387, Issue 6729, Page 91-97, January 2025.
Engineering synthetic phosphorylation signaling networks in human cells
Science, Volume 387, Issue 6729, Page 74-81, January 2025.
Bats surf storm fronts during spring migration
Science, Volume 387, Issue 6729, Page 97-102, January 2025.
Data crumbs and sitting ducks
Science, Volume 387, Issue 6729, Page 31-31, January 2025.
Hidden human costs of AI
Science, Volume 387, Issue 6729, Page 32-32, January 2025.
Migrating bats surf warm winds to soar hundreds of kilometers
Tiny transmitters reveal at least one bat species is surprisingly flexible in its migration timing and pathfinding
Better care urged for animal remains tied to Indigenous peoples
New recommendations stress tracing and respecting links between communities and animal bones, pelts, and other remains
Deep learning predicts DNA methylation regulatory variants in specific brain cell types and enhances fine mapping for brain disorders
DNA methylation (DNAm) is essential for brain development and function and potentially mediates the effects of genetic risk variants underlying brain disorders. We present INTERACT, a transformer-based deep learning model to predict regulatory variants affecting DNAm levels in specific brain cell types, leveraging existing single-nucleus DNAm data from the human brain. We show that INTERACT accurately predicts cell type-specific DNAm profiles, achieving an average area under the receiver...
Increased alpha-synuclein phosphorylation and oligomerization and altered enzymes in plasma of patients with Parkinson's disease
The brain of patients with Parkinson's disease (PD) was characterized by increased phosphorylation and oligomerization of α-synuclein (α-syn) and altered activity of enzymes regulating α-syn phosphorylation and oligomerization. Whether increased α-syn phosphorylation and oligomerization as well as related enzyme changes can be detected in the plasma of PD patients remains unclear. Here, we showed that human α-syn proteins incubated in PD plasma formed more oligomerized α-syn (O-α-syn) and...
The effects of loss of Y chromosome on male health
Loss of Y chromosome (LOY) is the most commonly occurring post-zygotic (somatic) mutation in male individuals. The past decade of research suggests that LOY has important effects in shaping the activity of the immune system, and multiple studies have shown the effects of LOY on a range of diseases, including cancer, neurodegeneration, cardiovascular disease and acute infection. Epidemiological findings have been corroborated by functional analyses providing insights into the mechanisms by which...
Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice
Cellular senescence plays a critical role in repeated ultraviolet (UV) exposure-induced skin photoaging. Currently, from the perspective of regulating senescent cells, potent compounds or reliable protein targets that could effectively prevent skin photoaging have not yet been reported. Herein, we demonstrated that chlorogenic acid (CGA) significantly inhibited UVA-induced senescence of human dermis skin fibroblasts (HDF) cells by screening the natural product library. The activity-based protein...
P2Y<sub>2</sub> Inhibition Modifies the Anabolic Response to Exercise in Adult Mice
As the aging population continues to grow, the incidence of osteoporotic fractures increases and is compounded by our lack of therapeutic strategies that increase bone formation. Although exercise and physical activity play a key role in maintaining bone mass throughout our lives, the loads and exertion required to elicit an anabolic response becomes exceedingly difficult to achieve with age. Based on previous work, the P2Y(2) receptor offers a unique therapeutic target to increasing bone mass...
Middle-Aged and Young People's Perspectives on Healthy Aging Through Exercise: Environmental, Psychosocial, and Individual Factors With the Photovoice Method
The aim of this study is to examine the individual's perspective on healthy aging through exercise. Individuals aged 18-60 years who have been physically active for at least one year were included in this study. The study focused on the exercise behaviors of young and middle-aged individuals through photographs. The photovoice method was used to discover how healthy aging affects exercise behaviors in physically active individuals. Content analysis was used to analyze photographs and the...
Histone mark age of human tissues and cell types
Aging is a complex and multifaceted process involving many epigenetic alterations. One key area of interest in aging research is the role of histone modifications, which can dynamically regulate gene expression. Here, we conducted a pan-tissue analysis of the dynamics of seven key histone modifications during human aging. Our histone-specific age prediction models showed surprisingly accurate performance, proving resilient to experimental and artificial noise. Simulation experiments for...