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CONCLUSIONS: Multidomain geriatric indicators including anthropometric status (body mass index), walking aid use, cognitive function, age, and exhaustion can guide pragmatic, community-based screening for possible sarcopenia. Simple, accessible assessments of these predictors may facilitate earlier identification and referral, and should be considered in sarcopenia screening and prevention strategies.

CONCLUSIONS: Individuals with BHL did not show increased visual or somatosensory reliance and overall as a group showed similar balance performance to adults with normal hearing. Greater severity of hearing loss was associated with worse performance regardless of age. This study supports the role of regular exercise as protective against balance dysfunction in aging with or without hearing loss.

Life-history trade-offs between reproduction and survival are well documented, yet the biological mechanisms underlying costs remain unclear. Telomere length (TL) is a potential biomarker for such costs, although its association with reproductive efforts is mixed. Bats, particularly the long-lived greater horseshoe bat (Rhinolophus ferrumequinum), provide a rare opportunity to explore these dynamics due to their longevity and low reproductive rates. We examined telomere dynamics in 202 female R....

Specific class of immune cells help keep virus at bay for months or years—even in the absence of drugs

Age-related neurodegenerative diseases involve reduced cell numbers and impaired behavioral capacity. Neurodegeneration and behavioral deficits also occur during aging, and notably in the absence of disease. The cerebellum, which modulates movement and cognition, is susceptible to cell loss in both aging and disease. Here, we demonstrate that cerebellar Purkinje cell loss in aged mice is not spatially random but rather occurs in a pattern of parasagittal stripes. We also find that aged mice...

The proprioceptive and visual systems play a major role in daily tasks by providing continuous feedback to the central nervous system (CNS) for coordinating movements. However, it remains unclear to what extent alterations in the proprioceptive system and CNS affect vibration-induced illusion of movement (VIM) with age and after a stroke. To address this, 29 young (26 ± 7 years), 30 older (63 ± 8 years), and 26 stroke participants (68 ± 12 years) with left arm impairment, all right-handed,...

Caloric (CR) or dietary (DR) restriction improves health and extends lifespan in multiple species. However, the beneficial effects of DR may diminish if introduced late in life, emphasizing the importance of timing for promoting healthspan and avoiding adverse outcomes. Using a metabolomics approach, we investigated the metabolic responses in plasma, liver, and kidney of mice on acute and chronic DR at various ages. Two hundred and five mice including young (2-month-old; n = 72), middle-aged...