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Scientific distinctions between coca and cocaine support policy reform

3 months 2 weeks ago
Science, Volume 390, Issue 6775, Page 782-785, November 2025.
Dawson M. White, Ricardo Soberón Garrido, Caroline S. Conzelman, Wade Davis, Claude Guislain, Anthony Henman, Orlando Adolfo Jara-Muñoz, Martin Jelsma, Susana Mejía, Daniel Montoya-Cataño, Oscar Alejandro Pérez-Escobar, David Alfonso Restrepo, Yenny…

Phase 1/2a clinical trial of hESC-derived dopamine progenitors in Parkinson's disease

3 months 2 weeks ago
Parkinson's disease (PD) has long been considered an appropriate candidate for cell replacement therapy. We generated high-purity dopaminergic progenitors (A9-DPCs) from human embryonic stem cells and evaluated their safety and exploratory efficacy in a single-center, open-label, dose-escalation phase 1/2a trial (NCT05887466) for PD patients. Twelve patients with moderate-to-severe PD received bilateral putamen transplantation of low-dose (3.15 million cells; n = 6) or high-dose (6.30 million...
Jin Woo Chang