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Evaluating a Mobile Integrated Health Transitional Care Program to Reduce Readmissions: Findings From a Quasi-Experimental Design
CONCLUSIONS: An in-home mobile integrated health (MIH) transitional care program for frail older adults after hospital discharge was associated with lower 30-day readmission rates. These findings highlight MIH as a promising model to support aging in place and suggest its potential value for adoption within age-friendly health systems.
p62/SQSTM1 Condensation Modulates Mitochondrial Clustering to Participate in Mitochondrial Quality Control
Mitochondrial quality control is tightly associated with aging-related neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Previous studies reported that ALS/FTD-associated protein p62 drives "mitochondrial clustering" (perinuclear clustering of fragmented and swollen mitochondria) during PINK1/Parkin-mediated mitophagy, but the underlying molecular mechanism, especially the precise role of p62 in...
Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health
Aging is the primary risk factor for many neuromuscular (NM) diseases that impair motor and cognitive function. Transplantation of young muscle-derived stem/progenitor cells (MDSPCs) has shown remarkable therapeutic potential across a range of age-related diseases, primarily through paracrine mechanisms. In this study, secretome profiling of young MDSPCs revealed a unique enrichment of pro-angiogenic and immunomodulatory proteins compared to their aged counterparts. Our systemic transplantation...
Can science build a better working dog?
New approaches could put talented canines into the hands of more people with disabilities
Politics and war complicate global effort to study changes to Earth’s poles
As preparations for the fifth International Polar Year kick off, organizers grapple with U.S. climate skepticism and Russia’s invasion of Ukraine
A Yangtze without fishers — but not without fish
Daily briefing: Hunter-gatherers in Europe’s ‘water world’ resisted the switch to farming for millennia
Grant proposals drafted with AI help more likely to win NIH funding
US repeals key ‘endangerment finding’ that climate change is a public threat
How some COVID vaccines triggered rare blood-clot disorder
Stewarding AI in agriculture research
Science, Volume 391, Issue 6786, February 2026.
Erratum for the Research Article “WAPL functions as a rheostat of Protocadherin isoform diversity that controls neural wiring”
Science, Volume 391, Issue 6786, February 2026.
Erratum for the Research Article “Of the first five US states with food waste bans, Massachusetts alone has reduced landfill waste”
Science, Volume 391, Issue 6786, February 2026.
Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation
Science, Volume 391, Issue 6786, February 2026.
Mitochondrial control of fuel switching via carnitine biosynthesis
Science, Volume 391, Issue 6786, February 2026.
Detecting supramolecular organic nanoparticles during heat wave
Science, Volume 391, Issue 6786, February 2026.
Structural ontogeny of protein-protein interactions
Science, Volume 391, Issue 6786, February 2026.
Poxvirus attack of antiviral defense pathways unleashes an effector-triggered NF-κB response
Science, Volume 391, Issue 6786, February 2026.
Transcription factor Etv3 controls the tolerogenic function of dendritic cells
Science, Volume 391, Issue 6786, February 2026.
Myelin sheaths in the central nervous system can withstand damage and dynamically remodel
Science, Volume 391, Issue 6786, February 2026.