Aggregator

Single-cell multiomics provides critical insights into how disease-associated variants identified through genome-wide association studies (GWASs) influence transcription factor eRegulons within a specific cellular context; however, the regulatory roles of genetic variants in aging and disease remain unclear. Here, we present scMORE, a method that integrates single-cell transcriptomes and chromatin accessibility with GWAS summary statistics to identify cell-type-specific eRegulons associated with...

No abstract

CONCLUSIONS: Cumulative risks during the COVID-19 pandemic escalated, with pandemic responses such as lockdowns increasing the adverse effects of social isolation and loneliness on positive affect of very old adults. Our pooled-multi-sample design allows a quantitative investigation of an understudied population, offering researchers new insights and an empirical strategy to utilize.

CONCLUSIONS: Incident diabetes was associated with accelerated progression of frailty in older adults, particularly in the domain of instrumental activities of daily living. Regular functional assessments and targeted interventions following diabetes diagnosis was important, especially for high-risk subgroups including the oldest-old, unmarried individuals, and those with lower BMI.

Brain aging can cause cognitive and motor disabilities which often correlate with changes in dendritic branch, axon collateral, and synapse numbers. However, from invertebrates to mammals, age-related decline is typically restricted to specific neuron types or brain parts, indicating differential vulnerability. The rules to pinpoint the susceptibility of distinct brain elements to aging remain largely unknown. Here, we combine longitudinal studies with neuroanatomical, electrophysiological, and...

Ziziphus jujuba Mill. (ZJ) is a traditional medicinal plant known for its antioxidant, anti-inflammatory, and neuroprotective properties, yet its role in learning and cognitive regulation remains insufficiently explored. Huang Jing (Polygonatum sibiricum), a Qi- and Yin-tonifying herb in Traditional Chinese Medicine, has historically been used to combat fatigue, support brain function, delay aging, and regulate metabolic balance. In this study, we evaluated the neuroprotective and antioxidant...

CONCLUSION: Cardiometabolic risk factors play a significant role in late-life cognitive decline and death among older Indians. These longitudinal relationships from LASI-DAD highlight potentially modifiable risk factors and inform potential prevention policies.

CONCLUSIONS: Higher prevalence of clinically relevant depression in certain groups and increased risk possibly reflect unfavorable socioeconomic changes that occurred for the elderly population in Poland in the analyzed period.

Artificial Intelligence (AI) is transforming geriatric healthcare by improving early disease detection, optimizing patient management, and enhancing clinical decision-making. AI-driven tools, including machine learning (ML) algorithms, predictive analytics, and assistive robotics, are increasingly utilized to address challenges associated with aging, such as frailty, multimorbidity, polypharmacy, and fall prevention. These technologies can facilitate personalized medicine, improve diagnostic...

This scoping review provides key trends in the use of the Delphi method applied to geriatrics and gerontology research, and documents key information that can be used in the planning of future Delphi studies, like recruitment rates, number of Delphi rounds and panelists, attrition, consensus definitions, and stakeholders engaged.

Jeanne Marrazzo says she lost her job because she spoke out against risky public health policies

Astronauts could theoretically harness frozen water on the Red Planet to construct habitats and research stations, new analysis suggests

Parkinson's Disease (PD) is characterized by motor symptoms, loss of dopaminergic neurons, and oxidative stress in the Substantia Nigra pars compacta (SNpc) and striatum of patients, as well as in models of parkinsonism. Recent studies show that the endocannabinoid system present in the basal ganglia has a strong influence on the progression of PD, with the inhibition of the enzyme Monoacylglycerol Lipase (MAGL) being a promising therapeutic strategy. Therefore, the aim of this study was to...

Worldwide, the population is aging. Most older adults would prefer not to move from their current residence; however, there are human resource challenges in home care service provision. Smart home technology has evolved over the past decades and could provide an adjunct to home care and potentially delay moving to a higher level of care. This paper provides an overview of supportive smart home technology, which expands smart home technology to enable feedback and action based on daily...

CONCLUSION: Twelve weeks of ST, but not PT, significantly increased circulating sαKL levels in pre-frail older adults. Given the beneficial health effects of increased sαKL, these findings suggest that ST may offer additional biological advantages relevant to healthy aging. sαKL may serve as a promising biomarker for training-induced adaptions, but prospective trials are needed to confirm long-term effects and further clarify underlying mechanisms.