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Evolution of thumbnails across Rodentia
Science, Volume 389, Issue 6764, Page 1049-1053, September 2025.
Photochemical H2 dissociation for nearly quantitative CO2 reduction to ethylene
Science, Volume 389, Issue 6764, Page 1037-1042, September 2025.
Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia
Science, Volume 389, Issue 6764, Page 1043-1048, September 2025.
Estrogen-regulated renal progenitors determine pregnancy adaptation and preeclampsia
Science, Volume 389, Issue 6764, Page 1016-1023, September 2025.
Valuing women’s work
Science, Volume 389, Issue 6764, Page 982-982, September 2025.
The end of human exceptionalism
Science, Volume 389, Issue 6764, Page 983-983, September 2025.
Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations
Science, Volume 390, Issue 6769, Page 164-172, October 2025.
A clearer view of the current phase of unrest at Campi Flegrei caldera
Science, Volume 390, Issue 6768, Page 70-75, October 2025.
Cumulative impacts to global marine ecosystems projected to more than double by mid-century
Science, Volume 389, Issue 6766, Page 1216-1219, September 2025.
Harvard victory leaves scientists feeling vindicated but uncertain
Trump administration vows to appeal ruling that it illegally cut $2.2 billion in research funding
The last gift: How bodies donated for research may help find a cure for HIV
Pioneering project uses “rapid autopsies” to find virus hideouts in infected people
New ‘hyperlocal’ forecasts aim to give Indian cities early warning of monsoon floods
In Mumbai, new tools provided up to 3 days notice of dangerous downpours
Ancient skeletons’ genes reveal origin of the Slavic people
DNA connects modern Slavs to a wave of migration following the fall of the Roman Empire
Ant queen lays eggs that hatch into two species
Bizarre discovery of interspecies cloning “almost impossible to believe,” biologists say
Data from defunct NASA lander paint a radical new picture of Mars’s interior
Studies identify a solid inner core and buried remnants of giant impacts
Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer's disease
Neuroinflammation drives Alzheimer's disease (AD) pathogenesis. Z-DNA, a non-canonical left-handed DNA structure, activates innate immune signaling through Z-DNA-binding protein 1 (ZBP1). However, the functional significance of ZBP1-mediated Z-DNA detection in AD remains undefined. Here, we found that ZBP1 is amplified in AD microglia, driving innate immune responses and neuroinflammation through sensing Z-form mitochondrial DNA (mtDNA). We show that oxidized mtDNA, generated by amyloid-β...
Tailoring the biomarkers of Alzheimer's disease using a gut microbiome-centric approach: Preclinical, clinical, and regulatory perspectives
Alzheimer's disease (AD), a progressive neurodegenerative disorder, poses significant therapeutic challenges due to its complex etiology and limited treatment options. Traditional pharmacotherapies targeting amyloid-β (Aβ) and cholinergic pathways offer modest benefits and are often associated with adverse effects. Emerging evidence implicates gut dysbiosis and the gut-brain axis in the pathogenesis and progression of AD. This review explores the multifactorial pathophysiology of AD and...
From adaptive deep brain stimulation to adaptive circuit targeting
Deep brain stimulation (DBS) substantially improves motor symptoms and quality of life in people with movement disorders such as Parkinson disease and dystonia, and it is also being explored as a treatment option for other brain disorders, including treatment-resistant obsessive-compulsive disorder, Alzheimer disease and depression. Two major developments are currently driving progress in DBS research: first, the framework of adaptive DBS, which senses brain activity to infer the momentary state...
Biomarker-related phospho-tau217 appears in synapses around Abeta plaques prior to tau tangle in cerebral cortex of preclinical Alzheimer's disease
Phospho-tau protein p-tau181 is a cerebrospinal fluid biomarker for Alzheimer's disease (AD), while p-tau217 is the most sensitive plasma biomarker for cerebral amyloid β (Aβ) load prior to tau pathology in preclinical AD. Diagnostic and prognostic use of these p-tau biomarkers requires neuropathological interpretation. Here, we analyzed the cellular localization of biomarker p-tau species in postmortem human brains harboring different extents of Aβ plaque and tau pathology. Signals for p-tau217...
TREM2 mediates parkinsonism-like neurodegeneration in carbon disulfide-induced neurotoxicity
Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic neurons and aggregation of α-Synuclein (α-Syn). While both genetic and environmental factors are implicated in PD pathogenesis, the mechanisms underlying neurodegeneration induced by environmental toxins and associated genetic responses remain largely unknown. Recently, triggering receptor expressed on myeloid cells 2 (TREM2) has been proven to be a critical mediator of toxin-induced motor...