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Six Drivers of Aging Identified Among Genes Differentially Expressed With Age
Many studies have compared gene expression in young and old samples to gain insights on aging, the primary risk factor for most chronic diseases. However, these studies only identify associations without distinguishing drivers of aging from compensatory geroprotective responses or incidental downstream effects. Here, we introduce a workflow to characterize causal effects of differentially expressed genes on lifespan. First, we performed a meta-analysis of 25 gene expression datasets comprising...
Preservation of Autophagy May Be a Mechanism Behind Healthy Aging
Autophagy is intricately linked with protective cellular processes, including mitochondrial function, proteostasis, and cellular senescence. Animal studies have indicated that autophagy becomes dysfunctional with aging and may contribute to T cell immunosenescence. In humans, it remains unclear whether autophagy is impaired in CD4^(+) T cells as people age. To answer this question, we examined basal and inducible autophagic activity in a series of experiments comparing CD4^(+) T cells from...
Lactate Secretion by Monocytes as a Determinant of Innate Immune Cell Fitness in Healthy Elderly
Immune cell metabolism is increasingly recognized as an important regulator of immune function, but its role in age-related immune dysfunction, chronic inflammation, and cardiometabolic complications in humans remains incompletely understood. This study investigated the impact of aging on monocyte metabolic and functional signatures in a healthy elderly population. We aimed to leverage these immunometabolic signatures to identify healthy elderly individuals with reduced immune cell fitness and,...
DNA from rum-soaked fishes chronicles century of environmental change
Museum specimens collected during a 1907 marine expedition reveal loss of genetic diversity in the Philippines
Economics Nobel celebrates researchers who showed how science and technology drive growth
Joel Mokyr, Philippe Aghion, and Peter Howitt explained why the past 2 centuries have seen sustained economic growth rather than stagnation
Daily briefing: Corals have been pushed beyond an irreversible tipping point, says report
Men’s brains shrink faster than women’s: what that means for Alzheimer’s
Economics Nobel prize won by researchers who showed how science boosts growth
‘Am I redundant?’: how AI changed my career in bioinformatics
What an academic misconduct accusation taught me about sharing research
Digital flocks, predators allow ecologists to simulate real-world animal behaviour
Birds’ intruder alert hints at how sounds took on new meanings
Andean peoples hunted and gathered long after they embraced farming
Defending Ohuira Bay, Mexico
Host cell Z-RNAs activate ZBP1 during virus infections
Alchemy: discredited pseudoscience or chemistry’s worthy ancestor?
Metals are key to the global economy — but three challenges threaten supply chains
Parkinson's disease: emerging opportunities through global collaboration
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Analysis of EEG coherence according to the onset of Alzheimer's disease
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, the effects of which can be slowed down by an early and correct diagnosis. Greater diagnostic accuracy depends on a better understanding of the disease. In this regard, electroencephalography is a promising low-cost tool to explore brain activity and support the diagnosis of AD. When analyzing EEG signals, age is a factor that is not usually taken into account despite being one of the main risk factors. In this work,...
Anti-amyloid monoclonal antibody therapies in Alzheimer's disease - a scoping review
Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide, and with advancements in the medical field, Anti-amyloid monoclonal antibodies (AA mAbs) targeting amyloid-β have emerged as potential disease-modifying agents altering AD pathology. This scoping review mapped the characteristics, patterns, and gaps in clinical trials investigating the efficacy and safety of AA mAbs in AD treatments, with focus on cognitive, functional, biochemical, imaging, and...