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Targeting RANKL Prevents Bone Loss, Improves Muscle Function and Extends Lifespan in Progeroid Mice
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by the early development of pathological features associated with aging, ultimately leading to premature death. HGPS primarily affects tissues of mesenchymal origin, as evidenced by the clinical manifestations characteristic of this premature aging disorder, including, but not limited to, osteoporosis, muscle wasting, lipodystrophy, and cardiovascular disease. In this study, we used preclinical mouse models and...
Daily briefing: AI agents sniff out decades-old errors in scientific literature
Maladaptive trained immunity as a hematopoietic stem cell driver of inflammaging
Turning the tide: restoring Mozambican mangroves — in photos
Where are you ticklish? Researchers map the sensation across cultures
How and when to use artificial intelligence in your science job application
Learning millisecond protein dynamics from what is missing in NMR spectra
Despite global turmoil, Gen Z researchers are not giving up
This AI tool claims to pick the top 1% of preprints. Should researchers trust it?
Why environmental treaties must also address mental health
What to do when you have too many PhD projects on the go
I caught my students using AI to cheat in an exam — here’s what universities must do to stamp this out
Author Correction: Nucleolar URB1 ensures 3′ ETS rRNA removal to prevent exosome surveillance
Author Correction: Cooperation conflicts with equality when allocating public goods
Author Correction: Durable all-inorganic perovskite tandem photovoltaics
A daily glass of fruit juice was linked to lower depression scores
A daily glass of 100% fruit juice or a smoothie may help improve more than just fruit intake. In a small four-week trial, participants who added one to a healthier diet showed significantly lower depression scores, hinting that a simple dietary change could also support mental well-being.
Scientists find the strength training “sweet spot” for a longer life
Just a couple of hours of strength training each week could have surprisingly powerful effects on longevity. People who lifted weights for around 90 to 120 minutes weekly had a 13% lower risk of dying early, with especially large reductions in deaths from cardiovascular and neurological diseases. Pairing strength training with regular aerobic exercise was even more impressive, lowering overall death risk by about 45%.
Frequent cannabis users wake up with their “stress hormone” already elevated
Frequent cannabis users may wake up with unusually high levels of the stress hormone cortisol, suggesting their daily stress rhythms could be disrupted. Researchers say the finding raises questions about whether using cannabis for stress relief might, over time, interfere with the very system that helps the body handle stress.
For decades, we were told to choose low-fat dairy. New research says otherwise
Full-fat dairy may be healthier than conventional advice has suggested. In a 12-week study, adults who ate three servings a day showed no meaningful increases in weight, body fat, cholesterol, or insulin resistance. They also experienced improved blood pressure and consumed more calcium, protein, and vitamin D. The findings suggest dairy’s complex structure may matter more than its saturated fat content alone.
Mitochondria Dictate Progressive Versus Bimodal Aging of the Mammary Gland
The incidence of breast cancer shows its largest peak around the age of 65 but also a peak around 45 indicating a bimodal distribution. While some potential explanations, such as age-related enrichment in specific breast cancer sub-types and BRCA1/2 mutations were proposed, they do not explain why the peaks are at 45 and 65, raising the possibility that the way the breast ages may play a role. Here using two mouse models, we show two distinct aging patterns of the mammary gland; one being...